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Enteroscopic sclerotherapy in blue rubber bleb nevus syndrome.

Ning S, Zhang Y, Zu Z, Mao X, Mao G - Pak J Med Sci (2015 Jan-Feb)

Bottom Line: Blue rubber bleb nevus syndrome (BRBNS) is a rare syndrome characterized by multiple vascular malformations of varying size and appearance that present predominantly on the skin and within the gastrointestinal tract and, less often, in other internal organs.Gastrointestinal lesions of BRBNS can cause acute or chronic bleeding, and the treatment is challenging.In this case, we reported a successful treatment of vascular malformations in all segments of gastrointestinal tract, including the small intestine, by endoscopic sclerotherapy, in a 10-year-old boy with BRBNS.

View Article: PubMed Central - PubMed

Affiliation: Shoubin Ning, Department of Gastroenterology, General Hospital of Air Force, PLA, Beijing, China.

ABSTRACT
Blue rubber bleb nevus syndrome (BRBNS) is a rare syndrome characterized by multiple vascular malformations of varying size and appearance that present predominantly on the skin and within the gastrointestinal tract and, less often, in other internal organs. Gastrointestinal lesions of BRBNS can cause acute or chronic bleeding, and the treatment is challenging. In this case, we reported a successful treatment of vascular malformations in all segments of gastrointestinal tract, including the small intestine, by endoscopic sclerotherapy, in a 10-year-old boy with BRBNS.

No MeSH data available.


Related in: MedlinePlus

(A) The lesion in tongue; (B) The lesion in the sole of left foot; (C) The lesions in stomach; (D) The lesions in colon.
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Figure 1: (A) The lesion in tongue; (B) The lesion in the sole of left foot; (C) The lesions in stomach; (D) The lesions in colon.

Mentions: The patient was a 10-year-old boy with no family history of BRBNS. At birth, no obvious abnormality was noted. From 4-year-old, the child was gradually found to have multiple blue nevus in the tongue and the skins on the sole of left foot, right forearm, neck and genitalia, etc (Fig. 1A and 1B). From 6-year-old, he began to present with recurrent melena, and sometimes dark red bloody stool, often resulting in severe anemia with hemoglobin levels that even dropped blow 35 g/L. Gastroscopic and colonoscopic examination in the local hospital revealed multiple hemangiomas in the esophagus, stomach and colon (Fig. 1C and 1D), and therefore in combination with the skin lesions, the child was diagnosed as BRBNS. In 2012, the child patient received therapeutic sclerotherapy several times for the gastrointestinal vascular malformations by using gastroscope and colonoscope, in which about total 20 hemangiomas were treated. However, after the treatment, he still presented with recurrent melena and bloody stool, and consequent anemia.


Enteroscopic sclerotherapy in blue rubber bleb nevus syndrome.

Ning S, Zhang Y, Zu Z, Mao X, Mao G - Pak J Med Sci (2015 Jan-Feb)

(A) The lesion in tongue; (B) The lesion in the sole of left foot; (C) The lesions in stomach; (D) The lesions in colon.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4386193&req=5

Figure 1: (A) The lesion in tongue; (B) The lesion in the sole of left foot; (C) The lesions in stomach; (D) The lesions in colon.
Mentions: The patient was a 10-year-old boy with no family history of BRBNS. At birth, no obvious abnormality was noted. From 4-year-old, the child was gradually found to have multiple blue nevus in the tongue and the skins on the sole of left foot, right forearm, neck and genitalia, etc (Fig. 1A and 1B). From 6-year-old, he began to present with recurrent melena, and sometimes dark red bloody stool, often resulting in severe anemia with hemoglobin levels that even dropped blow 35 g/L. Gastroscopic and colonoscopic examination in the local hospital revealed multiple hemangiomas in the esophagus, stomach and colon (Fig. 1C and 1D), and therefore in combination with the skin lesions, the child was diagnosed as BRBNS. In 2012, the child patient received therapeutic sclerotherapy several times for the gastrointestinal vascular malformations by using gastroscope and colonoscope, in which about total 20 hemangiomas were treated. However, after the treatment, he still presented with recurrent melena and bloody stool, and consequent anemia.

Bottom Line: Blue rubber bleb nevus syndrome (BRBNS) is a rare syndrome characterized by multiple vascular malformations of varying size and appearance that present predominantly on the skin and within the gastrointestinal tract and, less often, in other internal organs.Gastrointestinal lesions of BRBNS can cause acute or chronic bleeding, and the treatment is challenging.In this case, we reported a successful treatment of vascular malformations in all segments of gastrointestinal tract, including the small intestine, by endoscopic sclerotherapy, in a 10-year-old boy with BRBNS.

View Article: PubMed Central - PubMed

Affiliation: Shoubin Ning, Department of Gastroenterology, General Hospital of Air Force, PLA, Beijing, China.

ABSTRACT
Blue rubber bleb nevus syndrome (BRBNS) is a rare syndrome characterized by multiple vascular malformations of varying size and appearance that present predominantly on the skin and within the gastrointestinal tract and, less often, in other internal organs. Gastrointestinal lesions of BRBNS can cause acute or chronic bleeding, and the treatment is challenging. In this case, we reported a successful treatment of vascular malformations in all segments of gastrointestinal tract, including the small intestine, by endoscopic sclerotherapy, in a 10-year-old boy with BRBNS.

No MeSH data available.


Related in: MedlinePlus