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Prognostic significance of Cbx4 expression and its beneficial effect for transarterial chemoembolization in hepatocellular carcinoma.

Jiao HK, Xu Y, Li J, Wang W, Mei Z, Long XD, Chen GQ - Cell Death Dis (2015)

Bottom Line: By univariate and multivariate analyses, we show that Cbx4 is an independent prognostic factor of HCC, and both TAE and TACE treatments have no effects on the overall survival in HCC patients with low Cbx4 expression.Moreover, Cbx4 overexpression enhances while Cbx4 silencing antagonizes doxorubicin-induced cell death of HCC cell lines.In conclusion, Cbx4 is an independent prognostic factor for HCC patients, and the patients with high Cbx4 expression should receive postoperative TACE treatment to improve their survival.

View Article: PubMed Central - PubMed

Affiliation: Institute of Health Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences/Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200025, China.

ABSTRACT
Our recent investigations showed that polycomb chromobox 4 (Cbx4) promotes angiogenesis and metastasis of hepatocellular carcinoma (HCC) through its sumoylating action on hypoxia-inducible factor-1α protein. Here, we attempt to identify the prognostic significances of Cbx4 by a retrospective analyses in 727 cases of HCC patients with and without postoperative transarterial chemoembolization (TACE) or transarterial embolization (TAE). Binary logistic regression tests indicated that Cbx4 is correlated with histological grading, tumor-node-metastasis stage, microvessel density, distant metastasis and hematogenous metastasis of HCC. By univariate and multivariate analyses, we show that Cbx4 is an independent prognostic factor of HCC, and both TAE and TACE treatments have no effects on the overall survival in HCC patients with low Cbx4 expression. More intriguingly, TACE prolongs, while TAE shortens, the overall survival of HCC patients with high Cbx4 expression, indicating that Cbx4 is a good biomarker on decision-making to perform postoperative TACE in HCC patients. Moreover, Cbx4 overexpression enhances while Cbx4 silencing antagonizes doxorubicin-induced cell death of HCC cell lines. In conclusion, Cbx4 is an independent prognostic factor for HCC patients, and the patients with high Cbx4 expression should receive postoperative TACE treatment to improve their survival.

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Cbx4 expression is positively correlated with histological grading and metastasis of HCC. (a) The representative images for Cbx4 expression and H&E staining in tumors with low and high grade and with or without vascular invasion. (b–f) The undifferential risk (b), high TNM stage (c), HM+ risk (d), distant metastasis risk+ (e) and high MVD risk (f) were compared between tumors with high and low Cbx4 expression in 727 cases of HCC patients. Corresponding risk value odds ratio is calculated using binary logistical regression with likelihood-ratio test for forward method
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fig1: Cbx4 expression is positively correlated with histological grading and metastasis of HCC. (a) The representative images for Cbx4 expression and H&E staining in tumors with low and high grade and with or without vascular invasion. (b–f) The undifferential risk (b), high TNM stage (c), HM+ risk (d), distant metastasis risk+ (e) and high MVD risk (f) were compared between tumors with high and low Cbx4 expression in 727 cases of HCC patients. Corresponding risk value odds ratio is calculated using binary logistical regression with likelihood-ratio test for forward method

Mentions: Next, we assessed the potential relationship between Cbx4 expression and standard variables of HCC patients by χ2 test. The results showed that Cbx4 expression was positively correlated with histological grading, MVD and TNM stage as well as distant metastasis and hematogenous metastasis (HM), two HCC features obtained from the end of follow-up interviews or the last follow-up interview before death (Table 2). Cancer tissues with high histological grade (Figure 1a) presented high scores of Cbx4 staining, and cancer tissues with high Cbx4 expression presented more vascular invasion (Figure 1a). Moreover, higher Cbx4 expression increased the undifferential risk of HCC with an odds ratio (OR) of 1.365 (95% CI 1.008–1.849, P=0.044; Figure 1b), high TNM risk (OR 2.191, 95% CI 1.505–3.190, P=3.3 × 10-5; Figure 1c), HM risk (OR 1.797, 95% CI 1.256–2.573, P=0.001; Figure 1d), and distant metastasis risk (OR 2.349, 95% CI 1.001–5.454, P=0.041; Figure 1e) besides MVD reported previously (OR 11.706, 95% CI 8.170−16.772, P=4.3 × 10−47; Figure 1f).


Prognostic significance of Cbx4 expression and its beneficial effect for transarterial chemoembolization in hepatocellular carcinoma.

Jiao HK, Xu Y, Li J, Wang W, Mei Z, Long XD, Chen GQ - Cell Death Dis (2015)

Cbx4 expression is positively correlated with histological grading and metastasis of HCC. (a) The representative images for Cbx4 expression and H&E staining in tumors with low and high grade and with or without vascular invasion. (b–f) The undifferential risk (b), high TNM stage (c), HM+ risk (d), distant metastasis risk+ (e) and high MVD risk (f) were compared between tumors with high and low Cbx4 expression in 727 cases of HCC patients. Corresponding risk value odds ratio is calculated using binary logistical regression with likelihood-ratio test for forward method
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4385935&req=5

fig1: Cbx4 expression is positively correlated with histological grading and metastasis of HCC. (a) The representative images for Cbx4 expression and H&E staining in tumors with low and high grade and with or without vascular invasion. (b–f) The undifferential risk (b), high TNM stage (c), HM+ risk (d), distant metastasis risk+ (e) and high MVD risk (f) were compared between tumors with high and low Cbx4 expression in 727 cases of HCC patients. Corresponding risk value odds ratio is calculated using binary logistical regression with likelihood-ratio test for forward method
Mentions: Next, we assessed the potential relationship between Cbx4 expression and standard variables of HCC patients by χ2 test. The results showed that Cbx4 expression was positively correlated with histological grading, MVD and TNM stage as well as distant metastasis and hematogenous metastasis (HM), two HCC features obtained from the end of follow-up interviews or the last follow-up interview before death (Table 2). Cancer tissues with high histological grade (Figure 1a) presented high scores of Cbx4 staining, and cancer tissues with high Cbx4 expression presented more vascular invasion (Figure 1a). Moreover, higher Cbx4 expression increased the undifferential risk of HCC with an odds ratio (OR) of 1.365 (95% CI 1.008–1.849, P=0.044; Figure 1b), high TNM risk (OR 2.191, 95% CI 1.505–3.190, P=3.3 × 10-5; Figure 1c), HM risk (OR 1.797, 95% CI 1.256–2.573, P=0.001; Figure 1d), and distant metastasis risk (OR 2.349, 95% CI 1.001–5.454, P=0.041; Figure 1e) besides MVD reported previously (OR 11.706, 95% CI 8.170−16.772, P=4.3 × 10−47; Figure 1f).

Bottom Line: By univariate and multivariate analyses, we show that Cbx4 is an independent prognostic factor of HCC, and both TAE and TACE treatments have no effects on the overall survival in HCC patients with low Cbx4 expression.Moreover, Cbx4 overexpression enhances while Cbx4 silencing antagonizes doxorubicin-induced cell death of HCC cell lines.In conclusion, Cbx4 is an independent prognostic factor for HCC patients, and the patients with high Cbx4 expression should receive postoperative TACE treatment to improve their survival.

View Article: PubMed Central - PubMed

Affiliation: Institute of Health Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences/Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200025, China.

ABSTRACT
Our recent investigations showed that polycomb chromobox 4 (Cbx4) promotes angiogenesis and metastasis of hepatocellular carcinoma (HCC) through its sumoylating action on hypoxia-inducible factor-1α protein. Here, we attempt to identify the prognostic significances of Cbx4 by a retrospective analyses in 727 cases of HCC patients with and without postoperative transarterial chemoembolization (TACE) or transarterial embolization (TAE). Binary logistic regression tests indicated that Cbx4 is correlated with histological grading, tumor-node-metastasis stage, microvessel density, distant metastasis and hematogenous metastasis of HCC. By univariate and multivariate analyses, we show that Cbx4 is an independent prognostic factor of HCC, and both TAE and TACE treatments have no effects on the overall survival in HCC patients with low Cbx4 expression. More intriguingly, TACE prolongs, while TAE shortens, the overall survival of HCC patients with high Cbx4 expression, indicating that Cbx4 is a good biomarker on decision-making to perform postoperative TACE in HCC patients. Moreover, Cbx4 overexpression enhances while Cbx4 silencing antagonizes doxorubicin-induced cell death of HCC cell lines. In conclusion, Cbx4 is an independent prognostic factor for HCC patients, and the patients with high Cbx4 expression should receive postoperative TACE treatment to improve their survival.

Show MeSH
Related in: MedlinePlus