Hydroxy-α sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9.
Bottom Line: Hydroxy-α sanshool (HAS), a readily absorbable active ingredient of TU-100 and a KCNK3/KCNK9/KCNK18 blocker as well as TRPV1/TRPA1 agonist, has been investigated for its effects on colonic motility.The effect of HAS was unaltered by TRPV1/TRPA1 antagonists and desensitization.HAS may evoke strong LDC possibly via blockage of the neural KCNK9 channel in the colonic myenteric plexus.
Affiliation: Tsumura Research Laboratories, Tsumura & Co., Ibaraki, Japan;Show MeSH
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Mentions: To investigate whether HAS accelerates defecation in vivo we examined the amount of feces accumulated during a short period after treatment with the agents. The accumulated number of fecal pellets increased significantly at 5 h after oral administration of 50 mg/kg HAS to normal rats (Fig. 9A).
Affiliation: Tsumura Research Laboratories, Tsumura & Co., Ibaraki, Japan;