Hydroxy-α sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9.
Bottom Line: Hydroxy-α sanshool (HAS), a readily absorbable active ingredient of TU-100 and a KCNK3/KCNK9/KCNK18 blocker as well as TRPV1/TRPA1 agonist, has been investigated for its effects on colonic motility.The effect of HAS was unaltered by TRPV1/TRPA1 antagonists and desensitization.HAS may evoke strong LDC possibly via blockage of the neural KCNK9 channel in the colonic myenteric plexus.
Affiliation: Tsumura Research Laboratories, Tsumura & Co., Ibaraki, Japan;Show MeSH
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Mentions: The contractions induced by 10 μM HAS were suppressed almost completely by addition of TTX (0.3 μM), a neuroleptic agent (Fig. 8A). By contrast, the contractions induced by HBS were not abolished but its shape was changed by TTX (Fig. 8B). Addition of high doses (up to 3 mM) of TTX did not alter the effect of Lid (1 mM, data not shown).
Affiliation: Tsumura Research Laboratories, Tsumura & Co., Ibaraki, Japan;