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Hydroxy-α sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9.

Kubota K, Ohtake N, Ohbuchi K, Mase A, Imamura S, Sudo Y, Miyano K, Yamamoto M, Kono T, Uezono Y - Am. J. Physiol. Gastrointest. Liver Physiol. (2015)

Bottom Line: Hydroxy-α sanshool (HAS), a readily absorbable active ingredient of TU-100 and a KCNK3/KCNK9/KCNK18 blocker as well as TRPV1/TRPA1 agonist, has been investigated for its effects on colonic motility.The effect of HAS was unaltered by TRPV1/TRPA1 antagonists and desensitization.HAS may evoke strong LDC possibly via blockage of the neural KCNK9 channel in the colonic myenteric plexus.

View Article: PubMed Central - PubMed

Affiliation: Tsumura Research Laboratories, Tsumura & Co., Ibaraki, Japan;

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Motor activity induced by HBS and Lid. The typical patterns of HBS (A) and Lid (B) on a spatiotemporal map and intraluminal pressure chart are shown.
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Figure 7: Motor activity induced by HBS and Lid. The typical patterns of HBS (A) and Lid (B) on a spatiotemporal map and intraluminal pressure chart are shown.

Mentions: Although HAS, HBS, and Lid raised the intraluminal pressure of rat isolated colons and induced potent contraction/motility, the resulting motor patterns differed among these three compounds. Although the pressure peaks induced by HAS were strong and repeated periodically with almost the same frequency, those induced by HBS were lower in frequency and less periodic (Fig. 7A, Supplementary Video S6). The effects induced by Lid were also weaker in amplitude, not periodic, but higher in frequency than those induced by HAS (Fig. 7B, Supplementary Video S7). The spatiotemporal maps also suggested that HAS induces potent motor activity propagating from the oral side to the aboral side over the entire proximal colon (Fig. 1A), whereas Lid was found to induce high-frequency, low-amplitude, nonpropulsive motor activity (Fig. 7B). Table 1 shows the PF of HAS-, HBS-, and Lid-induced colonic motility.


Hydroxy-α sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9.

Kubota K, Ohtake N, Ohbuchi K, Mase A, Imamura S, Sudo Y, Miyano K, Yamamoto M, Kono T, Uezono Y - Am. J. Physiol. Gastrointest. Liver Physiol. (2015)

Motor activity induced by HBS and Lid. The typical patterns of HBS (A) and Lid (B) on a spatiotemporal map and intraluminal pressure chart are shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4385894&req=5

Figure 7: Motor activity induced by HBS and Lid. The typical patterns of HBS (A) and Lid (B) on a spatiotemporal map and intraluminal pressure chart are shown.
Mentions: Although HAS, HBS, and Lid raised the intraluminal pressure of rat isolated colons and induced potent contraction/motility, the resulting motor patterns differed among these three compounds. Although the pressure peaks induced by HAS were strong and repeated periodically with almost the same frequency, those induced by HBS were lower in frequency and less periodic (Fig. 7A, Supplementary Video S6). The effects induced by Lid were also weaker in amplitude, not periodic, but higher in frequency than those induced by HAS (Fig. 7B, Supplementary Video S7). The spatiotemporal maps also suggested that HAS induces potent motor activity propagating from the oral side to the aboral side over the entire proximal colon (Fig. 1A), whereas Lid was found to induce high-frequency, low-amplitude, nonpropulsive motor activity (Fig. 7B). Table 1 shows the PF of HAS-, HBS-, and Lid-induced colonic motility.

Bottom Line: Hydroxy-α sanshool (HAS), a readily absorbable active ingredient of TU-100 and a KCNK3/KCNK9/KCNK18 blocker as well as TRPV1/TRPA1 agonist, has been investigated for its effects on colonic motility.The effect of HAS was unaltered by TRPV1/TRPA1 antagonists and desensitization.HAS may evoke strong LDC possibly via blockage of the neural KCNK9 channel in the colonic myenteric plexus.

View Article: PubMed Central - PubMed

Affiliation: Tsumura Research Laboratories, Tsumura & Co., Ibaraki, Japan;

Show MeSH
Related in: MedlinePlus