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Genetic polymorphisms in the vitamin D pathway in relation to lung cancer risk and survival.

Kong J, Xu F, Qu J, Wang Y, Gao M, Yu H, Qian B - Oncotarget (2015)

Bottom Line: Studies have suggested that vitamin D may have protective effects against cancer development or tumor progression.In the case-control comparison, we found SNP rs3782130 (CYP27B1), rs7041 (GC), rs6068816 and rs4809957 (CYP24A1) associated with NSCLC risk.CYP27B1 and CYP24A1 expression were significantly different between tumor and normal tissues in NSCLC.

View Article: PubMed Central - PubMed

Affiliation: Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China.

ABSTRACT
Studies have suggested that vitamin D may have protective effects against cancer development or tumor progression. To search for additional evidence, we investigated the role of genetic polymorphisms involved in the vitamin D pathway in non-small cell lung cancer (NSCLC). We evaluated common genetic polymorphisms associated with the vitamin D pathway in relation to NSCLC in a case-control study of 603 newly diagnosed NSCLC patients and 661 matched healthy controls. Seven single nucleotide polymorphisms (SNPs) were genotyped, the expression of CYP27B1 and CYP24A1 were measured in 153 tumor samples and their associations with genotypes and patient survival were also analyzed. In the case-control comparison, we found SNP rs3782130 (CYP27B1), rs7041 (GC), rs6068816 and rs4809957 (CYP24A1) associated with NSCLC risk. The risk of NSCLC was increased with the number of risk alleles. CYP27B1 and CYP24A1 expression were significantly different between tumor and normal tissues in NSCLC. High CYP27B1 expression was associated with better overall survival, and the expression was different by the rs3782130 genotype. The study suggests that some genetic polymorphisms involved in the vitamin D pathway may associate with NSCLC risk, and one of the polymorphisms (rs3782130) may affect gene expression and patient survival.

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Related in: MedlinePlus

Associations of CYP27B1 and CYP24A1expression with overall survival of 153 NSCLC patientsKaplan-Meier survival analysis showed that patients with high CYP27B1 expression had better overall survival than those with low CYP27B1 (p=0.018, Figure 2A). No significant association was found between CYP24A1 expression and NSCLC survival (p=0.621, Figure 2B).
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Figure 2: Associations of CYP27B1 and CYP24A1expression with overall survival of 153 NSCLC patientsKaplan-Meier survival analysis showed that patients with high CYP27B1 expression had better overall survival than those with low CYP27B1 (p=0.018, Figure 2A). No significant association was found between CYP24A1 expression and NSCLC survival (p=0.621, Figure 2B).

Mentions: Levels of CYP27B1 and CYP24A1 expression in tumor tissues were analyzed in 153 NSCLC patients. Based on the median expression, patients were categorized into high and low expression groups. Kaplan-Meier survival analysis showed that patients with high CYP27B1 expression had better overall survival than those with low CYP27B1 (p=0.018, Figure 2A). No significant association was found between CYP24A1 expression and NSCLC survival (p=0.621, Figure 2B).


Genetic polymorphisms in the vitamin D pathway in relation to lung cancer risk and survival.

Kong J, Xu F, Qu J, Wang Y, Gao M, Yu H, Qian B - Oncotarget (2015)

Associations of CYP27B1 and CYP24A1expression with overall survival of 153 NSCLC patientsKaplan-Meier survival analysis showed that patients with high CYP27B1 expression had better overall survival than those with low CYP27B1 (p=0.018, Figure 2A). No significant association was found between CYP24A1 expression and NSCLC survival (p=0.621, Figure 2B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4385872&req=5

Figure 2: Associations of CYP27B1 and CYP24A1expression with overall survival of 153 NSCLC patientsKaplan-Meier survival analysis showed that patients with high CYP27B1 expression had better overall survival than those with low CYP27B1 (p=0.018, Figure 2A). No significant association was found between CYP24A1 expression and NSCLC survival (p=0.621, Figure 2B).
Mentions: Levels of CYP27B1 and CYP24A1 expression in tumor tissues were analyzed in 153 NSCLC patients. Based on the median expression, patients were categorized into high and low expression groups. Kaplan-Meier survival analysis showed that patients with high CYP27B1 expression had better overall survival than those with low CYP27B1 (p=0.018, Figure 2A). No significant association was found between CYP24A1 expression and NSCLC survival (p=0.621, Figure 2B).

Bottom Line: Studies have suggested that vitamin D may have protective effects against cancer development or tumor progression.In the case-control comparison, we found SNP rs3782130 (CYP27B1), rs7041 (GC), rs6068816 and rs4809957 (CYP24A1) associated with NSCLC risk.CYP27B1 and CYP24A1 expression were significantly different between tumor and normal tissues in NSCLC.

View Article: PubMed Central - PubMed

Affiliation: Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China.

ABSTRACT
Studies have suggested that vitamin D may have protective effects against cancer development or tumor progression. To search for additional evidence, we investigated the role of genetic polymorphisms involved in the vitamin D pathway in non-small cell lung cancer (NSCLC). We evaluated common genetic polymorphisms associated with the vitamin D pathway in relation to NSCLC in a case-control study of 603 newly diagnosed NSCLC patients and 661 matched healthy controls. Seven single nucleotide polymorphisms (SNPs) were genotyped, the expression of CYP27B1 and CYP24A1 were measured in 153 tumor samples and their associations with genotypes and patient survival were also analyzed. In the case-control comparison, we found SNP rs3782130 (CYP27B1), rs7041 (GC), rs6068816 and rs4809957 (CYP24A1) associated with NSCLC risk. The risk of NSCLC was increased with the number of risk alleles. CYP27B1 and CYP24A1 expression were significantly different between tumor and normal tissues in NSCLC. High CYP27B1 expression was associated with better overall survival, and the expression was different by the rs3782130 genotype. The study suggests that some genetic polymorphisms involved in the vitamin D pathway may associate with NSCLC risk, and one of the polymorphisms (rs3782130) may affect gene expression and patient survival.

Show MeSH
Related in: MedlinePlus