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Identifying the most sensitive and specific sign and symptom combinations for cholera: results from an analysis of laboratory-based surveillance data from Haiti, 2012-2013.

Lucien MA, Schaad N, Steenland MW, Mintz ED, Emmanuel R, Freeman N, Boncy J, Adrien P, Joseph GA, Katz MA - Am. J. Trop. Med. Hyg. (2015)

Bottom Line: Since October 2010, over 700,000 cholera cases have been reported in Haiti.We used data from laboratory-based surveillance for diarrhea in Haiti to evaluate the sensitivity, specificity, and positive (PPV) and negative predictive values (NPV) of the cholera case definitions recommended by the World Health Organization (WHO).From April 2012 to May 2013, we tested 1,878 samples from hospitalized patients with acute watery diarrhea; 1,178 (62.7%) yielded Vibrio cholerae O1.

View Article: PubMed Central - PubMed

Affiliation: National Public Health Laboratory, Ministry of Public Health and Population, Port-au-Prince, Haiti; Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia; Division of Foodborne, Water and Environmental Diseases, National Center for Emerging and Zoonotic Infections, Centers for Disease Control and Prevention, Atlanta, Georgia; Directorate of Epidemiology, Laboratory and Research, Ministry of Public Health and Population, Port-au-Prince, Haiti; Centers for Disease Control and Prevention-Haiti, Port-au-Prince, Haiti lucienmentor@gmail.com.

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WHO standard case definitions for cholera surveillance.8
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Figure 1: WHO standard case definitions for cholera surveillance.8

Mentions: It has been over 4 years since the cholera epidemic began in Haiti. As the epidemic matures, having a better understanding of the accuracy of different sign and symptom combinations in accurately diagnosing laboratory-confirmed cholera is important to inform national surveillance guidelines and clinical decision making. We used data from a laboratory-based sentinel surveillance system for acute diarrheal illness in Haiti, which complements NCCS, to evaluate the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the two case definitions recommended by World Health Organization (WHO) for cholera surveillance (Figure 1), and other combinations of clinical signs and symptoms.


Identifying the most sensitive and specific sign and symptom combinations for cholera: results from an analysis of laboratory-based surveillance data from Haiti, 2012-2013.

Lucien MA, Schaad N, Steenland MW, Mintz ED, Emmanuel R, Freeman N, Boncy J, Adrien P, Joseph GA, Katz MA - Am. J. Trop. Med. Hyg. (2015)

WHO standard case definitions for cholera surveillance.8
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4385769&req=5

Figure 1: WHO standard case definitions for cholera surveillance.8
Mentions: It has been over 4 years since the cholera epidemic began in Haiti. As the epidemic matures, having a better understanding of the accuracy of different sign and symptom combinations in accurately diagnosing laboratory-confirmed cholera is important to inform national surveillance guidelines and clinical decision making. We used data from a laboratory-based sentinel surveillance system for acute diarrheal illness in Haiti, which complements NCCS, to evaluate the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the two case definitions recommended by World Health Organization (WHO) for cholera surveillance (Figure 1), and other combinations of clinical signs and symptoms.

Bottom Line: Since October 2010, over 700,000 cholera cases have been reported in Haiti.We used data from laboratory-based surveillance for diarrhea in Haiti to evaluate the sensitivity, specificity, and positive (PPV) and negative predictive values (NPV) of the cholera case definitions recommended by the World Health Organization (WHO).From April 2012 to May 2013, we tested 1,878 samples from hospitalized patients with acute watery diarrhea; 1,178 (62.7%) yielded Vibrio cholerae O1.

View Article: PubMed Central - PubMed

Affiliation: National Public Health Laboratory, Ministry of Public Health and Population, Port-au-Prince, Haiti; Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia; Division of Foodborne, Water and Environmental Diseases, National Center for Emerging and Zoonotic Infections, Centers for Disease Control and Prevention, Atlanta, Georgia; Directorate of Epidemiology, Laboratory and Research, Ministry of Public Health and Population, Port-au-Prince, Haiti; Centers for Disease Control and Prevention-Haiti, Port-au-Prince, Haiti lucienmentor@gmail.com.

Show MeSH
Related in: MedlinePlus