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Comparative analysis of local anesthesia with 2 different concentrations of adrenaline: a randomized and single blind study.

Managutti A, Prakasam M, Puthanakar N, Menat S, Shah D, Patel H - J Int Oral Health (2015)

Bottom Line: This study compared the efficacy and cardiovascular effects with the use of 2% lignocaine with two different concentrations.There was no significant difference in the efficacy and duration with the 2% lignocaine with 2 different concentrations. 2% lignocaine with 1:80000 adrenaline concentration has significantly increased the heart rate and blood pressure especially systolic compared with the lignocaine with 1:200000.Though 2% lignocaine with 1:80000 is widely used in India, 1:200000 adrenaline concentrations do not much affect the cardiovascular parameters.

View Article: PubMed Central - PubMed

Affiliation: Professor and Head, Vice Principal, Department of Oral & Maxillofacial Surgery, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India.

ABSTRACT

Background: Local anesthetic agents are more commonly used in dentistry to have painless procedure during surgical intervention in bone and soft tissue. There are many local anesthetic agents available with the wide selection of vaso-constrictive agents that improve the clinical efficacy and the duration of local anesthesia. Most commonly lignocaine with adrenaline is used in various concentrations. Systemically adrenaline like drugs can cause a number of cardiovascular disturbances while most are short lived, permanent injury or even death may follow in drug induced ventricular fibrillation, myocardial infarction or cerebro-vascular accidents. This study compared the efficacy and cardiovascular effects with the use of 2% lignocaine with two different concentrations.

Materials and methods: Forty patients underwent extractions of mandibular bilateral teeth using 2% lignocaine with two different concentrations - one with 1:80000 and the other with 1:200000.

Results: There was no significant difference in the efficacy and duration with the 2% lignocaine with 2 different concentrations. 2% lignocaine with 1:80000 adrenaline concentration has significantly increased the heart rate and blood pressure especially systolic compared with the lignocaine with 1:200000.

Conclusion: Though 2% lignocaine with 1:80000 is widely used in India, 1:200000 adrenaline concentrations do not much affect the cardiovascular parameters. So it is recommended to use 2% lignocaine with 1:200000 for cardiac patients.

No MeSH data available.


Related in: MedlinePlus

Comparison of diastolic blood pressure.
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Figure 4: Comparison of diastolic blood pressure.

Mentions: But when LA with 1:200000 adrenaline concentrations was used, there was no significant rise in the pulse rate. While assessing the systolic BP, there was rise significantly when LA with 1:80000 adrenaline concentrations was used whereas there was no major change observed when LA with 1:200000 was used as shown in Graph 3. There was slight rise in diastolic BP when LA with 1:80000 adrenaline was used but there was decrease when LA with 1:200000 adrenaline concentration as seen in the Graph 4.


Comparative analysis of local anesthesia with 2 different concentrations of adrenaline: a randomized and single blind study.

Managutti A, Prakasam M, Puthanakar N, Menat S, Shah D, Patel H - J Int Oral Health (2015)

Comparison of diastolic blood pressure.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4385721&req=5

Figure 4: Comparison of diastolic blood pressure.
Mentions: But when LA with 1:200000 adrenaline concentrations was used, there was no significant rise in the pulse rate. While assessing the systolic BP, there was rise significantly when LA with 1:80000 adrenaline concentrations was used whereas there was no major change observed when LA with 1:200000 was used as shown in Graph 3. There was slight rise in diastolic BP when LA with 1:80000 adrenaline was used but there was decrease when LA with 1:200000 adrenaline concentration as seen in the Graph 4.

Bottom Line: This study compared the efficacy and cardiovascular effects with the use of 2% lignocaine with two different concentrations.There was no significant difference in the efficacy and duration with the 2% lignocaine with 2 different concentrations. 2% lignocaine with 1:80000 adrenaline concentration has significantly increased the heart rate and blood pressure especially systolic compared with the lignocaine with 1:200000.Though 2% lignocaine with 1:80000 is widely used in India, 1:200000 adrenaline concentrations do not much affect the cardiovascular parameters.

View Article: PubMed Central - PubMed

Affiliation: Professor and Head, Vice Principal, Department of Oral & Maxillofacial Surgery, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India.

ABSTRACT

Background: Local anesthetic agents are more commonly used in dentistry to have painless procedure during surgical intervention in bone and soft tissue. There are many local anesthetic agents available with the wide selection of vaso-constrictive agents that improve the clinical efficacy and the duration of local anesthesia. Most commonly lignocaine with adrenaline is used in various concentrations. Systemically adrenaline like drugs can cause a number of cardiovascular disturbances while most are short lived, permanent injury or even death may follow in drug induced ventricular fibrillation, myocardial infarction or cerebro-vascular accidents. This study compared the efficacy and cardiovascular effects with the use of 2% lignocaine with two different concentrations.

Materials and methods: Forty patients underwent extractions of mandibular bilateral teeth using 2% lignocaine with two different concentrations - one with 1:80000 and the other with 1:200000.

Results: There was no significant difference in the efficacy and duration with the 2% lignocaine with 2 different concentrations. 2% lignocaine with 1:80000 adrenaline concentration has significantly increased the heart rate and blood pressure especially systolic compared with the lignocaine with 1:200000.

Conclusion: Though 2% lignocaine with 1:80000 is widely used in India, 1:200000 adrenaline concentrations do not much affect the cardiovascular parameters. So it is recommended to use 2% lignocaine with 1:200000 for cardiac patients.

No MeSH data available.


Related in: MedlinePlus