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Comparative analysis of local anesthesia with 2 different concentrations of adrenaline: a randomized and single blind study.

Managutti A, Prakasam M, Puthanakar N, Menat S, Shah D, Patel H - J Int Oral Health (2015)

Bottom Line: This study compared the efficacy and cardiovascular effects with the use of 2% lignocaine with two different concentrations.There was no significant difference in the efficacy and duration with the 2% lignocaine with 2 different concentrations. 2% lignocaine with 1:80000 adrenaline concentration has significantly increased the heart rate and blood pressure especially systolic compared with the lignocaine with 1:200000.Though 2% lignocaine with 1:80000 is widely used in India, 1:200000 adrenaline concentrations do not much affect the cardiovascular parameters.

View Article: PubMed Central - PubMed

Affiliation: Professor and Head, Vice Principal, Department of Oral & Maxillofacial Surgery, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India.

ABSTRACT

Background: Local anesthetic agents are more commonly used in dentistry to have painless procedure during surgical intervention in bone and soft tissue. There are many local anesthetic agents available with the wide selection of vaso-constrictive agents that improve the clinical efficacy and the duration of local anesthesia. Most commonly lignocaine with adrenaline is used in various concentrations. Systemically adrenaline like drugs can cause a number of cardiovascular disturbances while most are short lived, permanent injury or even death may follow in drug induced ventricular fibrillation, myocardial infarction or cerebro-vascular accidents. This study compared the efficacy and cardiovascular effects with the use of 2% lignocaine with two different concentrations.

Materials and methods: Forty patients underwent extractions of mandibular bilateral teeth using 2% lignocaine with two different concentrations - one with 1:80000 and the other with 1:200000.

Results: There was no significant difference in the efficacy and duration with the 2% lignocaine with 2 different concentrations. 2% lignocaine with 1:80000 adrenaline concentration has significantly increased the heart rate and blood pressure especially systolic compared with the lignocaine with 1:200000.

Conclusion: Though 2% lignocaine with 1:80000 is widely used in India, 1:200000 adrenaline concentrations do not much affect the cardiovascular parameters. So it is recommended to use 2% lignocaine with 1:200000 for cardiac patients.

No MeSH data available.


Related in: MedlinePlus

Comparing the onset of anesthesia in two groups subjectively and objectively.
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Figure 1: Comparing the onset of anesthesia in two groups subjectively and objectively.

Mentions: Safety and efficacy of the two solutions with two different concentrations of adrenaline were studied in 40 patients. The age varied from 18 to 80 while the mean age is 47. There were 23 males and 17 females. There was one case of anesthetic failure for both solutions. No systemic toxicity was observed. As observed in the Table 1 and Graph 1, there was no significant change in both the groups in the point of view of time of onset. With regard to the duration of action of LA, 1:80000 adrenaline concentrations showed more than that of 1:200000. This is due to the faster absorption of LA when used with less concentration of adrenaline. The amount of LA used for both the groups does not show any significant change. As shown in the Table 1, there was no change in the VAS scale as both the solutions had same efficacy.


Comparative analysis of local anesthesia with 2 different concentrations of adrenaline: a randomized and single blind study.

Managutti A, Prakasam M, Puthanakar N, Menat S, Shah D, Patel H - J Int Oral Health (2015)

Comparing the onset of anesthesia in two groups subjectively and objectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4385721&req=5

Figure 1: Comparing the onset of anesthesia in two groups subjectively and objectively.
Mentions: Safety and efficacy of the two solutions with two different concentrations of adrenaline were studied in 40 patients. The age varied from 18 to 80 while the mean age is 47. There were 23 males and 17 females. There was one case of anesthetic failure for both solutions. No systemic toxicity was observed. As observed in the Table 1 and Graph 1, there was no significant change in both the groups in the point of view of time of onset. With regard to the duration of action of LA, 1:80000 adrenaline concentrations showed more than that of 1:200000. This is due to the faster absorption of LA when used with less concentration of adrenaline. The amount of LA used for both the groups does not show any significant change. As shown in the Table 1, there was no change in the VAS scale as both the solutions had same efficacy.

Bottom Line: This study compared the efficacy and cardiovascular effects with the use of 2% lignocaine with two different concentrations.There was no significant difference in the efficacy and duration with the 2% lignocaine with 2 different concentrations. 2% lignocaine with 1:80000 adrenaline concentration has significantly increased the heart rate and blood pressure especially systolic compared with the lignocaine with 1:200000.Though 2% lignocaine with 1:80000 is widely used in India, 1:200000 adrenaline concentrations do not much affect the cardiovascular parameters.

View Article: PubMed Central - PubMed

Affiliation: Professor and Head, Vice Principal, Department of Oral & Maxillofacial Surgery, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India.

ABSTRACT

Background: Local anesthetic agents are more commonly used in dentistry to have painless procedure during surgical intervention in bone and soft tissue. There are many local anesthetic agents available with the wide selection of vaso-constrictive agents that improve the clinical efficacy and the duration of local anesthesia. Most commonly lignocaine with adrenaline is used in various concentrations. Systemically adrenaline like drugs can cause a number of cardiovascular disturbances while most are short lived, permanent injury or even death may follow in drug induced ventricular fibrillation, myocardial infarction or cerebro-vascular accidents. This study compared the efficacy and cardiovascular effects with the use of 2% lignocaine with two different concentrations.

Materials and methods: Forty patients underwent extractions of mandibular bilateral teeth using 2% lignocaine with two different concentrations - one with 1:80000 and the other with 1:200000.

Results: There was no significant difference in the efficacy and duration with the 2% lignocaine with 2 different concentrations. 2% lignocaine with 1:80000 adrenaline concentration has significantly increased the heart rate and blood pressure especially systolic compared with the lignocaine with 1:200000.

Conclusion: Though 2% lignocaine with 1:80000 is widely used in India, 1:200000 adrenaline concentrations do not much affect the cardiovascular parameters. So it is recommended to use 2% lignocaine with 1:200000 for cardiac patients.

No MeSH data available.


Related in: MedlinePlus