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Analgesia evaluation of 2 NSAID drugs as adjuvant in management of chronic temporomandibular disorders.

Kurita Varoli F, Sucena Pita M, Sato S, Issa JP, do Nascimento C, Pedrazzi V - ScientificWorldJournal (2015)

Bottom Line: The assessment of drug therapies was performed using visual analogue scale for pain on palpation followed by 11-point numerical scale to quantify pain during treatment.Statistical analysis has shown that, after 10 days of treatment, all therapies were effective for pain relief.It has been concluded that sodium diclofenac used as splint adjuvant therapy, promotes significant analgesia in a shorter time.

View Article: PubMed Central - PubMed

Affiliation: Department of Dental Materials and Prosthodontics, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café s/no, Monte Alegre, 14040-904 Ribeirão Preto, SP, Brazil.

ABSTRACT
The aim of this triple-blind full-randomized clinical trial was to quantify analgesia in masticatory muscles and temporomandibular joints after occlusal splint therapy associated with the adjuvant administration of nonsteroidal anti-inflammatory drugs (NSAID) isolated or associated with other therapeutic agents. Pain relief was also recorded. Eighteen volunteers who had been suffering from chronic pain in masticatory muscles due to temporomandibular disorders were selected after anamnesis and assessment using RDC/TMD translated to Portuguese. The 3 proposed treatments were NSAID (sodium diclofenac), panacea (sodium diclofenac + carisoprodol + acetaminophen + caffeine), and a placebo. The total treatment duration was 10 days, preceded and succeeded by patients' pain assessment. A washout interval of 11 days was established between each therapy. All participants received all treatments in different moments, in a full randomized crossover methodology. The assessment of drug therapies was performed using visual analogue scale for pain on palpation followed by 11-point numerical scale to quantify pain during treatment. Statistical analysis has shown that, after 10 days of treatment, all therapies were effective for pain relief. NSAID therapy promoted analgesia on the third day, while placebo only promoted analgesia in the eighth day. It has been concluded that sodium diclofenac used as splint adjuvant therapy, promotes significant analgesia in a shorter time.

No MeSH data available.


Related in: MedlinePlus

Pain scores (median and interquartile intervals) before and after treatment in the trapezius muscle from groups A (NSAID—sodium diclofenac), B (panacea—sodium diclofenac + carisoprodol + acetaminophen + caffeine), and C (placebo).
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Related In: Results  -  Collection


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fig2: Pain scores (median and interquartile intervals) before and after treatment in the trapezius muscle from groups A (NSAID—sodium diclofenac), B (panacea—sodium diclofenac + carisoprodol + acetaminophen + caffeine), and C (placebo).

Mentions: Data from VAS analysis are displayed in Figures 1, 2, 3, and 4. First and final values among evaluated groups did not show significant differences (P > 0.05), except for right masseter muscle, in which differences were observed between groups A and C (P < 0.05).


Analgesia evaluation of 2 NSAID drugs as adjuvant in management of chronic temporomandibular disorders.

Kurita Varoli F, Sucena Pita M, Sato S, Issa JP, do Nascimento C, Pedrazzi V - ScientificWorldJournal (2015)

Pain scores (median and interquartile intervals) before and after treatment in the trapezius muscle from groups A (NSAID—sodium diclofenac), B (panacea—sodium diclofenac + carisoprodol + acetaminophen + caffeine), and C (placebo).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4385689&req=5

fig2: Pain scores (median and interquartile intervals) before and after treatment in the trapezius muscle from groups A (NSAID—sodium diclofenac), B (panacea—sodium diclofenac + carisoprodol + acetaminophen + caffeine), and C (placebo).
Mentions: Data from VAS analysis are displayed in Figures 1, 2, 3, and 4. First and final values among evaluated groups did not show significant differences (P > 0.05), except for right masseter muscle, in which differences were observed between groups A and C (P < 0.05).

Bottom Line: The assessment of drug therapies was performed using visual analogue scale for pain on palpation followed by 11-point numerical scale to quantify pain during treatment.Statistical analysis has shown that, after 10 days of treatment, all therapies were effective for pain relief.It has been concluded that sodium diclofenac used as splint adjuvant therapy, promotes significant analgesia in a shorter time.

View Article: PubMed Central - PubMed

Affiliation: Department of Dental Materials and Prosthodontics, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café s/no, Monte Alegre, 14040-904 Ribeirão Preto, SP, Brazil.

ABSTRACT
The aim of this triple-blind full-randomized clinical trial was to quantify analgesia in masticatory muscles and temporomandibular joints after occlusal splint therapy associated with the adjuvant administration of nonsteroidal anti-inflammatory drugs (NSAID) isolated or associated with other therapeutic agents. Pain relief was also recorded. Eighteen volunteers who had been suffering from chronic pain in masticatory muscles due to temporomandibular disorders were selected after anamnesis and assessment using RDC/TMD translated to Portuguese. The 3 proposed treatments were NSAID (sodium diclofenac), panacea (sodium diclofenac + carisoprodol + acetaminophen + caffeine), and a placebo. The total treatment duration was 10 days, preceded and succeeded by patients' pain assessment. A washout interval of 11 days was established between each therapy. All participants received all treatments in different moments, in a full randomized crossover methodology. The assessment of drug therapies was performed using visual analogue scale for pain on palpation followed by 11-point numerical scale to quantify pain during treatment. Statistical analysis has shown that, after 10 days of treatment, all therapies were effective for pain relief. NSAID therapy promoted analgesia on the third day, while placebo only promoted analgesia in the eighth day. It has been concluded that sodium diclofenac used as splint adjuvant therapy, promotes significant analgesia in a shorter time.

No MeSH data available.


Related in: MedlinePlus