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Evolution of genetic techniques: past, present, and beyond.

Durmaz AA, Karaca E, Demkow U, Toruner G, Schoumans J, Cogulu O - Biomed Res Int (2015)

Bottom Line: Currently, more than 1800 disease genes have been identified, more than 2000 genetic tests have become available, and in conjunction with this at least 350 biotechnology-based products have been released onto the market.Novel technologies, particularly next generation sequencing, have dramatically accelerated the pace of biological research, while at the same time increasing expectations.In this paper, a brief summary of genetic history with short explanations of most popular genetic techniques is given.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Genetics, Ege University Faculty of Medicine, 35100 Izmir, Turkey.

ABSTRACT
Genetics is the study of heredity, which means the study of genes and factors related to all aspects of genes. The scientific history of genetics began with the works of Gregor Mendel in the mid-19th century. Prior to Mendel, genetics was primarily theoretical whilst, after Mendel, the science of genetics was broadened to include experimental genetics. Developments in all fields of genetics and genetic technology in the first half of the 20th century provided a basis for the later developments. In the second half of the 20th century, the molecular background of genetics has become more understandable. Rapid technological advancements, followed by the completion of Human Genome Project, have contributed a great deal to the knowledge of genetic factors and their impact on human life and diseases. Currently, more than 1800 disease genes have been identified, more than 2000 genetic tests have become available, and in conjunction with this at least 350 biotechnology-based products have been released onto the market. Novel technologies, particularly next generation sequencing, have dramatically accelerated the pace of biological research, while at the same time increasing expectations. In this paper, a brief summary of genetic history with short explanations of most popular genetic techniques is given.

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Landmarks in the history of genetics.
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fig1: Landmarks in the history of genetics.

Mentions: Due to rapid advances in genomic technologies, genetics analyses have become essential in clinical practice and research. During the past decade, a great stride has been made to unravel underlying mechanisms of genetic-related disorders. Landmarks in genetic history are summarized in Figure 1. Moreover, genetic testing methods have become widely accessible and feasible to perform even for small size laboratories in particular after the completion of Human Genome Project, which coincided with developments in computer technology. With the application of genetic testing for personalized medicine, we are at the beginning of an era that will provide new horizons in human health.


Evolution of genetic techniques: past, present, and beyond.

Durmaz AA, Karaca E, Demkow U, Toruner G, Schoumans J, Cogulu O - Biomed Res Int (2015)

Landmarks in the history of genetics.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4385642&req=5

fig1: Landmarks in the history of genetics.
Mentions: Due to rapid advances in genomic technologies, genetics analyses have become essential in clinical practice and research. During the past decade, a great stride has been made to unravel underlying mechanisms of genetic-related disorders. Landmarks in genetic history are summarized in Figure 1. Moreover, genetic testing methods have become widely accessible and feasible to perform even for small size laboratories in particular after the completion of Human Genome Project, which coincided with developments in computer technology. With the application of genetic testing for personalized medicine, we are at the beginning of an era that will provide new horizons in human health.

Bottom Line: Currently, more than 1800 disease genes have been identified, more than 2000 genetic tests have become available, and in conjunction with this at least 350 biotechnology-based products have been released onto the market.Novel technologies, particularly next generation sequencing, have dramatically accelerated the pace of biological research, while at the same time increasing expectations.In this paper, a brief summary of genetic history with short explanations of most popular genetic techniques is given.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Genetics, Ege University Faculty of Medicine, 35100 Izmir, Turkey.

ABSTRACT
Genetics is the study of heredity, which means the study of genes and factors related to all aspects of genes. The scientific history of genetics began with the works of Gregor Mendel in the mid-19th century. Prior to Mendel, genetics was primarily theoretical whilst, after Mendel, the science of genetics was broadened to include experimental genetics. Developments in all fields of genetics and genetic technology in the first half of the 20th century provided a basis for the later developments. In the second half of the 20th century, the molecular background of genetics has become more understandable. Rapid technological advancements, followed by the completion of Human Genome Project, have contributed a great deal to the knowledge of genetic factors and their impact on human life and diseases. Currently, more than 1800 disease genes have been identified, more than 2000 genetic tests have become available, and in conjunction with this at least 350 biotechnology-based products have been released onto the market. Novel technologies, particularly next generation sequencing, have dramatically accelerated the pace of biological research, while at the same time increasing expectations. In this paper, a brief summary of genetic history with short explanations of most popular genetic techniques is given.

Show MeSH