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The advances in research on the pharmacological effects of Fructus Ligustri Lucidi.

Pang Z, Zhi-yan Z, Wang W, Ma Y, Feng-ju N, Zhang X, Han C - Biomed Res Int (2015)

Bottom Line: Fructus Ligustri Lucidi is a well-known invigorator in Chinese materia medica with hepatoprotective effect, anticancer activity, antioxidant activity, and so on.And oleanolic acids are the major pharmacologically active components in Fructus Ligustri Lucidi.In this paper, the advances in research on pharmacological effects of Fructus Ligustri Lucidi were summarized by reviewing the recent related literature.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.

ABSTRACT
Fructus Ligustri Lucidi is a well-known invigorator in Chinese materia medica with hepatoprotective effect, anticancer activity, antioxidant activity, and so on. And oleanolic acids are the major pharmacologically active components in Fructus Ligustri Lucidi. So it has great value in medical health, and may be developed to a complementary and alternative medicine through further research. In this paper, the advances in research on pharmacological effects of Fructus Ligustri Lucidi were summarized by reviewing the recent related literature.

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The structure of ursolic acid.
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Related In: Results  -  Collection


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fig3: The structure of ursolic acid.

Mentions: It is well-known that hepatitis C virus (HCV) infection is a serious worldwide problem, which causes significant mortality and morbidity. Some reports have showed that HCV affects about 3% of the global population and approximately 20–30% have developed liver disease, such as liver cirrhosis and chronic hepatitis. To date, current therapy with adverse side effects has curative powers in about 50% of patients infected with HCV genotype 1 and many chronically infected patients remain untreated [28–30]. So the progress of searching for effective antiviral drugs against HCV continues to be needed. And more and more researchers have studied the HCV inhibitors from FFL. Fortunately, accumulating evidence indicates that some active compounds of FLL were claimed to have potent antiviral activities against HCV. Lingbao Kong et al. found that oleanolic acid and ursolic acid (Figure 3) extracted from FLL are two antiviral components that possess anti-HCV activity based on their isomeric structures. They could suppress intracellular HCV NS5B RdRp activity. Moreover, they significantly inhibited the replication of HCV genotype 1b replicon and HCV genotype 2a JFH1 virus. By contrast, the results of their studies showed that oleanolic acid has one CH3 branched to last ring at C-20 position instead of C-19 position, so oleanolic acid had the better antiviral effect. In this way, the antiviral activity could be improved by modifying some compounds [12, 13].


The advances in research on the pharmacological effects of Fructus Ligustri Lucidi.

Pang Z, Zhi-yan Z, Wang W, Ma Y, Feng-ju N, Zhang X, Han C - Biomed Res Int (2015)

The structure of ursolic acid.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4385624&req=5

fig3: The structure of ursolic acid.
Mentions: It is well-known that hepatitis C virus (HCV) infection is a serious worldwide problem, which causes significant mortality and morbidity. Some reports have showed that HCV affects about 3% of the global population and approximately 20–30% have developed liver disease, such as liver cirrhosis and chronic hepatitis. To date, current therapy with adverse side effects has curative powers in about 50% of patients infected with HCV genotype 1 and many chronically infected patients remain untreated [28–30]. So the progress of searching for effective antiviral drugs against HCV continues to be needed. And more and more researchers have studied the HCV inhibitors from FFL. Fortunately, accumulating evidence indicates that some active compounds of FLL were claimed to have potent antiviral activities against HCV. Lingbao Kong et al. found that oleanolic acid and ursolic acid (Figure 3) extracted from FLL are two antiviral components that possess anti-HCV activity based on their isomeric structures. They could suppress intracellular HCV NS5B RdRp activity. Moreover, they significantly inhibited the replication of HCV genotype 1b replicon and HCV genotype 2a JFH1 virus. By contrast, the results of their studies showed that oleanolic acid has one CH3 branched to last ring at C-20 position instead of C-19 position, so oleanolic acid had the better antiviral effect. In this way, the antiviral activity could be improved by modifying some compounds [12, 13].

Bottom Line: Fructus Ligustri Lucidi is a well-known invigorator in Chinese materia medica with hepatoprotective effect, anticancer activity, antioxidant activity, and so on.And oleanolic acids are the major pharmacologically active components in Fructus Ligustri Lucidi.In this paper, the advances in research on pharmacological effects of Fructus Ligustri Lucidi were summarized by reviewing the recent related literature.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.

ABSTRACT
Fructus Ligustri Lucidi is a well-known invigorator in Chinese materia medica with hepatoprotective effect, anticancer activity, antioxidant activity, and so on. And oleanolic acids are the major pharmacologically active components in Fructus Ligustri Lucidi. So it has great value in medical health, and may be developed to a complementary and alternative medicine through further research. In this paper, the advances in research on pharmacological effects of Fructus Ligustri Lucidi were summarized by reviewing the recent related literature.

Show MeSH