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The Case of an Elderly Male Patient with Unknown Primary Mucinous Adenocarcinoma within Presacral Teratoma (Teratoma with Malignant Transformation).

Tanriverdi O, Ersen A, Cokmert S, Koca E, Bulut N, Gul S, Yilmaz N - Case Rep Oncol Med (2015)

Bottom Line: The primary treatment of teratomas with malignant transformations is surgical.Effect of radiotherapy and chemotherapy is not clear in patients, to whom surgical operation cannot be applied, or those who are with residual tumor, even if surgical operation can be applied to them, or those who are at metastatic stage.In this paper, we presented a 76-year-old male patient due to the histologic diagnosis of mucinous adenocarcinoma within teratoma, in whom approximately 7 cm presacral mass was found during the radiographic examination made by the reason of low back pain and pelvic pain.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Sitki Kocman University Faculty of Medicine, 48000 Mugla, Turkey.

ABSTRACT
Teratomas are rarely seen in adults, and presacral region is an area where they rarely settle in. Similarly, only about 1% of teratomas show malignant transformation. Malignant transformation is often associated with the area where teratoma settles in. Malignant transformation of mediastinal teratomas is more frequent than the ones located in retroperitoneal area and gonad. They most commonly show rhabdomyosarcoma, primitive neuroectodermal tumor, enteric adenocarcinoma, and leukemia transformation. In teratomas showing malignant transformation, the clinical course is aggressive; and survival of patients with metastatic disease is very low. The primary treatment of teratomas with malignant transformations is surgical. Effect of radiotherapy and chemotherapy is not clear in patients, to whom surgical operation cannot be applied, or those who are with residual tumor, even if surgical operation can be applied to them, or those who are at metastatic stage. In this paper, we presented a 76-year-old male patient due to the histologic diagnosis of mucinous adenocarcinoma within teratoma, in whom approximately 7 cm presacral mass was found during the radiographic examination made by the reason of low back pain and pelvic pain.

No MeSH data available.


Related in: MedlinePlus

(a) The lining of some cysts was composed of ciliated columnar. (b) There were papillary structures with hyalinized stroma and ciliated columnar epithelium. (c) In some areas, there was a multiloculated cystic appearance of the tumor, most of which were filled with mucinous matrix. (d) Inside the mucin pools, there were atypical and mitotically active cells, with increased nuclear/cytoplasmic ratio; (e) the MIB-1 staining was high in these cells which were considered as malignant.
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fig2: (a) The lining of some cysts was composed of ciliated columnar. (b) There were papillary structures with hyalinized stroma and ciliated columnar epithelium. (c) In some areas, there was a multiloculated cystic appearance of the tumor, most of which were filled with mucinous matrix. (d) Inside the mucin pools, there were atypical and mitotically active cells, with increased nuclear/cytoplasmic ratio; (e) the MIB-1 staining was high in these cells which were considered as malignant.

Mentions: In the pelvic magnetic resonance imaging, a mass lesion was observed, which was separated with thin septations in the dimension of approximately 7 × 5.5 cm at os coccyx level, a part of which shines both in T1 and in T2, a part of which gives high signals in T1, and which had intense involvement of peripheral and septal heterogeneous contrast from postcontrast study (Figure 1). No other findings suggestive of malignancy were observed in his thorax and abdominal computed tomography. Total excision of the presacral mass was made (Figure 2). The histopathological diagnosis of the patient, in whom no postoperative complication was observed, was reported as teratoma containing mucinous adenocarcinoma.


The Case of an Elderly Male Patient with Unknown Primary Mucinous Adenocarcinoma within Presacral Teratoma (Teratoma with Malignant Transformation).

Tanriverdi O, Ersen A, Cokmert S, Koca E, Bulut N, Gul S, Yilmaz N - Case Rep Oncol Med (2015)

(a) The lining of some cysts was composed of ciliated columnar. (b) There were papillary structures with hyalinized stroma and ciliated columnar epithelium. (c) In some areas, there was a multiloculated cystic appearance of the tumor, most of which were filled with mucinous matrix. (d) Inside the mucin pools, there were atypical and mitotically active cells, with increased nuclear/cytoplasmic ratio; (e) the MIB-1 staining was high in these cells which were considered as malignant.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4385620&req=5

fig2: (a) The lining of some cysts was composed of ciliated columnar. (b) There were papillary structures with hyalinized stroma and ciliated columnar epithelium. (c) In some areas, there was a multiloculated cystic appearance of the tumor, most of which were filled with mucinous matrix. (d) Inside the mucin pools, there were atypical and mitotically active cells, with increased nuclear/cytoplasmic ratio; (e) the MIB-1 staining was high in these cells which were considered as malignant.
Mentions: In the pelvic magnetic resonance imaging, a mass lesion was observed, which was separated with thin septations in the dimension of approximately 7 × 5.5 cm at os coccyx level, a part of which shines both in T1 and in T2, a part of which gives high signals in T1, and which had intense involvement of peripheral and septal heterogeneous contrast from postcontrast study (Figure 1). No other findings suggestive of malignancy were observed in his thorax and abdominal computed tomography. Total excision of the presacral mass was made (Figure 2). The histopathological diagnosis of the patient, in whom no postoperative complication was observed, was reported as teratoma containing mucinous adenocarcinoma.

Bottom Line: The primary treatment of teratomas with malignant transformations is surgical.Effect of radiotherapy and chemotherapy is not clear in patients, to whom surgical operation cannot be applied, or those who are with residual tumor, even if surgical operation can be applied to them, or those who are at metastatic stage.In this paper, we presented a 76-year-old male patient due to the histologic diagnosis of mucinous adenocarcinoma within teratoma, in whom approximately 7 cm presacral mass was found during the radiographic examination made by the reason of low back pain and pelvic pain.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Sitki Kocman University Faculty of Medicine, 48000 Mugla, Turkey.

ABSTRACT
Teratomas are rarely seen in adults, and presacral region is an area where they rarely settle in. Similarly, only about 1% of teratomas show malignant transformation. Malignant transformation is often associated with the area where teratoma settles in. Malignant transformation of mediastinal teratomas is more frequent than the ones located in retroperitoneal area and gonad. They most commonly show rhabdomyosarcoma, primitive neuroectodermal tumor, enteric adenocarcinoma, and leukemia transformation. In teratomas showing malignant transformation, the clinical course is aggressive; and survival of patients with metastatic disease is very low. The primary treatment of teratomas with malignant transformations is surgical. Effect of radiotherapy and chemotherapy is not clear in patients, to whom surgical operation cannot be applied, or those who are with residual tumor, even if surgical operation can be applied to them, or those who are at metastatic stage. In this paper, we presented a 76-year-old male patient due to the histologic diagnosis of mucinous adenocarcinoma within teratoma, in whom approximately 7 cm presacral mass was found during the radiographic examination made by the reason of low back pain and pelvic pain.

No MeSH data available.


Related in: MedlinePlus