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Osteoprotective effect of cordycepin on estrogen deficiency-induced osteoporosis in vitro and in vivo.

Zhang DW, Deng H, Qi W, Zhao GY, Cao XR - Biomed Res Int (2015)

Bottom Line: At the same time, we further investigated the effect of cordycepin in vitro assay.The beneficial effects of cordycepin on improvement of osteoporosis in rats were attributable mainly to decrease ALP activity, TRAP activity, and CTX level.These experimental results suggest that complement cordycepin is protective after ovariectomized osteopenic in specific way.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Xi Jing Hospital, The Fourth Military Medical University, Xi'an 710032, China.

ABSTRACT
The purpose of this study was to verify the effect of cordycepin on ovariectomized osteopenic rats. Fifty Wistar female rats used were divided into 5 groups: (1) sham-operation rats (control), (2) ovariectomized (OVX) rats with osteopenia, and (3) OVX'd rats with osteopenia treated with cordycepin (5 mg, 10 mg, and 20 mg) for 8 weeks. After the rats were treated orally with cordycepin, serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), serum osteocalcin (OC), homocysteine (HCY) , C-terminal crosslinked telopeptides of collagen type I (CTX) level, and oxidative stress were examined, respectively. The femoral neck was used for mechanical compression testing. At the same time, we further investigated the effect of cordycepin in vitro assay. The beneficial effects of cordycepin on improvement of osteoporosis in rats were attributable mainly to decrease ALP activity, TRAP activity, and CTX level. At the same time, cordycepin also increases the OC level in ovariectomized osteopenic rats. The histological examination clearly showed that dietary cordycepin can prevent bone loss caused by estrogen deficiency. These experimental results suggest that complement cordycepin is protective after ovariectomized osteopenic in specific way.

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Effects of cordycepin on bone ObPm/BPm. Data are expressed as the mean ± SEM (n = 10 per group). *P < 0.05, significant difference from vehicle-treated OVX rats.
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fig2: Effects of cordycepin on bone ObPm/BPm. Data are expressed as the mean ± SEM (n = 10 per group). *P < 0.05, significant difference from vehicle-treated OVX rats.

Mentions: Based on the results of mechanical strength, the trabecular number and thickness were studied. In the current study, we found that treatment of osteopenic OVX rats with cordycepin significantly increased maximal load compared to OVX animals. At the end of the 8-week treatment period, osteoblast surface in the lumbar vertebrae was not affected by OVX or any treatment (Figure 2(a)). A different cellular response was observed in the proximal tibial metaphysis. Cordycepin treatment caused a 3-fold increase in osteoblast surface compared with that in OVX rats (P < 0.05) (Figure 2(b)). It indicates that cordycepin administration improved bone strength mainly by increasing trabecular thickness. It agrees with the report of Ulrich [17].


Osteoprotective effect of cordycepin on estrogen deficiency-induced osteoporosis in vitro and in vivo.

Zhang DW, Deng H, Qi W, Zhao GY, Cao XR - Biomed Res Int (2015)

Effects of cordycepin on bone ObPm/BPm. Data are expressed as the mean ± SEM (n = 10 per group). *P < 0.05, significant difference from vehicle-treated OVX rats.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4385597&req=5

fig2: Effects of cordycepin on bone ObPm/BPm. Data are expressed as the mean ± SEM (n = 10 per group). *P < 0.05, significant difference from vehicle-treated OVX rats.
Mentions: Based on the results of mechanical strength, the trabecular number and thickness were studied. In the current study, we found that treatment of osteopenic OVX rats with cordycepin significantly increased maximal load compared to OVX animals. At the end of the 8-week treatment period, osteoblast surface in the lumbar vertebrae was not affected by OVX or any treatment (Figure 2(a)). A different cellular response was observed in the proximal tibial metaphysis. Cordycepin treatment caused a 3-fold increase in osteoblast surface compared with that in OVX rats (P < 0.05) (Figure 2(b)). It indicates that cordycepin administration improved bone strength mainly by increasing trabecular thickness. It agrees with the report of Ulrich [17].

Bottom Line: At the same time, we further investigated the effect of cordycepin in vitro assay.The beneficial effects of cordycepin on improvement of osteoporosis in rats were attributable mainly to decrease ALP activity, TRAP activity, and CTX level.These experimental results suggest that complement cordycepin is protective after ovariectomized osteopenic in specific way.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Xi Jing Hospital, The Fourth Military Medical University, Xi'an 710032, China.

ABSTRACT
The purpose of this study was to verify the effect of cordycepin on ovariectomized osteopenic rats. Fifty Wistar female rats used were divided into 5 groups: (1) sham-operation rats (control), (2) ovariectomized (OVX) rats with osteopenia, and (3) OVX'd rats with osteopenia treated with cordycepin (5 mg, 10 mg, and 20 mg) for 8 weeks. After the rats were treated orally with cordycepin, serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), serum osteocalcin (OC), homocysteine (HCY) , C-terminal crosslinked telopeptides of collagen type I (CTX) level, and oxidative stress were examined, respectively. The femoral neck was used for mechanical compression testing. At the same time, we further investigated the effect of cordycepin in vitro assay. The beneficial effects of cordycepin on improvement of osteoporosis in rats were attributable mainly to decrease ALP activity, TRAP activity, and CTX level. At the same time, cordycepin also increases the OC level in ovariectomized osteopenic rats. The histological examination clearly showed that dietary cordycepin can prevent bone loss caused by estrogen deficiency. These experimental results suggest that complement cordycepin is protective after ovariectomized osteopenic in specific way.

Show MeSH
Related in: MedlinePlus