Limits...
Metastasis of ciliary body melanoma to the contralateral eye: a case report and review of uveal melanoma literature.

Torossian NM, Wallace RT, Hwu WJ, Bedikian AY - Case Rep Oncol Med (2015)

Bottom Line: Many types of cancers metastasize to the eye.Two years later, upon progression of the disease in the right eye he had enucleation of the eye.We describe the patient's clinical history, the diagnosis of recurrent disease in the contralateral eye, therapy of the left eye, and systemic metastasis.

View Article: PubMed Central - PubMed

Affiliation: Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France.

ABSTRACT
Many types of cancers metastasize to the eye. However, uveal melanoma metastasizing to the contralateral choroid is very rare. We report the case of a 68-year-old man with history of treated uveal melanoma of the right eye that developed metastasis to the liver and the choroid of the left eye. Ten years earlier, he was diagnosed to have uveal melanoma of the right eye and was initially treated with plaque radiotherapy. Two years later, upon progression of the disease in the right eye he had enucleation of the eye. We describe the patient's clinical history, the diagnosis of recurrent disease in the contralateral eye, therapy of the left eye, and systemic metastasis. In addition, we reviewed the published medical literature and described the recent advances in the management of uveal melanoma.

No MeSH data available.


Related in: MedlinePlus

Fluorescein angiogram showing leakage of fluorescein (blue arrows) consistent with areas of choroidal infiltration seen on color photographs and late leakage with subretinal fluid (red arrow).
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4385596&req=5

fig2: Fluorescein angiogram showing leakage of fluorescein (blue arrows) consistent with areas of choroidal infiltration seen on color photographs and late leakage with subretinal fluid (red arrow).

Mentions: On 01/11/2005 the patient returned with decreased vision in his left eye of 1 week duration. He also complained of seeing black spots and floaters. An MRI of the brain performed on 01/12/2005 showed no evidence of intracranial metastases. On slit lamp fundoscopic examination, multiple small choroidal metastatic lesions were seen in the posterior pole/fundus of the left eye, each measuring about 300 to 500 microns in size, associated with an exudative retinal detachment centrally (Figure 1). Fluorescein angiogram (Figure 2) and Optical Coherence Tomography (Figure 3) confirmed presence of choroidal infiltration with melanoma. The patient's left eye was treated with plaque radiotherapy for palliation. A total activity of 46.67 millicuries was delivered using Iodine-125 plaque that was placed on 01/26/05. Dose was downgraded to 70 Gy from the typical 85 Gy and delivered quickly (in 47 hours) as this was a palliative attempt.


Metastasis of ciliary body melanoma to the contralateral eye: a case report and review of uveal melanoma literature.

Torossian NM, Wallace RT, Hwu WJ, Bedikian AY - Case Rep Oncol Med (2015)

Fluorescein angiogram showing leakage of fluorescein (blue arrows) consistent with areas of choroidal infiltration seen on color photographs and late leakage with subretinal fluid (red arrow).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4385596&req=5

fig2: Fluorescein angiogram showing leakage of fluorescein (blue arrows) consistent with areas of choroidal infiltration seen on color photographs and late leakage with subretinal fluid (red arrow).
Mentions: On 01/11/2005 the patient returned with decreased vision in his left eye of 1 week duration. He also complained of seeing black spots and floaters. An MRI of the brain performed on 01/12/2005 showed no evidence of intracranial metastases. On slit lamp fundoscopic examination, multiple small choroidal metastatic lesions were seen in the posterior pole/fundus of the left eye, each measuring about 300 to 500 microns in size, associated with an exudative retinal detachment centrally (Figure 1). Fluorescein angiogram (Figure 2) and Optical Coherence Tomography (Figure 3) confirmed presence of choroidal infiltration with melanoma. The patient's left eye was treated with plaque radiotherapy for palliation. A total activity of 46.67 millicuries was delivered using Iodine-125 plaque that was placed on 01/26/05. Dose was downgraded to 70 Gy from the typical 85 Gy and delivered quickly (in 47 hours) as this was a palliative attempt.

Bottom Line: Many types of cancers metastasize to the eye.Two years later, upon progression of the disease in the right eye he had enucleation of the eye.We describe the patient's clinical history, the diagnosis of recurrent disease in the contralateral eye, therapy of the left eye, and systemic metastasis.

View Article: PubMed Central - PubMed

Affiliation: Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France.

ABSTRACT
Many types of cancers metastasize to the eye. However, uveal melanoma metastasizing to the contralateral choroid is very rare. We report the case of a 68-year-old man with history of treated uveal melanoma of the right eye that developed metastasis to the liver and the choroid of the left eye. Ten years earlier, he was diagnosed to have uveal melanoma of the right eye and was initially treated with plaque radiotherapy. Two years later, upon progression of the disease in the right eye he had enucleation of the eye. We describe the patient's clinical history, the diagnosis of recurrent disease in the contralateral eye, therapy of the left eye, and systemic metastasis. In addition, we reviewed the published medical literature and described the recent advances in the management of uveal melanoma.

No MeSH data available.


Related in: MedlinePlus