Limits...
A new strategy for TiO2 whiskers mediated multi-mode cancer treatment.

Xu P, Wang R, Ouyang J, Chen B - Nanoscale Res Lett (2015)

Bottom Line: Traditional Chinese medicine (TCM) which functions as chemotherapeutic or adjuvantly chemotherapeutic agents has been drawing a great many eyeballs for its easy obtain and significant antitumor effects accompanied with less toxic and side effects.These results identify TiO2 Ws of good biocompatibility and photocatalytic activity.These results reveal that such modality combinations put forward a promising proposal in cancer therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008 People's Republic of China.

ABSTRACT
Traditional Chinese medicine (TCM) which functions as chemotherapeutic or adjuvantly chemotherapeutic agents has been drawing a great many eyeballs for its easy obtain and significant antitumor effects accompanied with less toxic and side effects. PDT (photodynamic therapy) utilizes the fact that certain compounds coined as photosensitizers, when exposed to light of a specific wavelength, are capable of generating cytotoxic reactive oxygen species (ROS) such as hydroxyl radical, hydrogen peroxide, and superoxide to kill cancer cells. Combinations of cancer therapeutic modalities are studied to improve the efficacy of treatment. This study aimed to explore a new strategy of coupling of titanium dioxide whiskers (TiO2 Ws) with the anticancer drug gambogic acid (GA) in photodynamic therapy. The nanocomposites were coined as GA-TiO2. The combination of TiO2 Ws with GA induced a remarkable enhancement in antitumor activity estimated by MTT assay, nuclear DAPI staining, and flow cytometry. Furthermore, the possible signaling pathway was explored by reverse transcription polymerase chain reaction (RT-PCR) and Western blot assay. These results identify TiO2 Ws of good biocompatibility and photocatalytic activity. In human leukemia cells (K562 cells), TiO2 Ws could obviously increase the intracellular concentration of GA and enhance its potential antitumor efficiency, suggesting that TiO2 Ws could act as an efficient drug delivery carrier targeting GA to carcinoma cells. Moreover, photodynamic GA-TiO2 nanocomposites could induce an evident reinforcement in antitumor activity with UV illumination. These results reveal that such modality combinations put forward a promising proposal in cancer therapy.

No MeSH data available.


Related in: MedlinePlus

Improvement in antitumor activity by photodynamic TiO2Ws loading GA. Schematic illustration of the possible mechanism of distinguished improvement in antitumor activity by photodynamic TiO2 Ws-loading GA.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4385221&req=5

Fig11: Improvement in antitumor activity by photodynamic TiO2Ws loading GA. Schematic illustration of the possible mechanism of distinguished improvement in antitumor activity by photodynamic TiO2 Ws-loading GA.

Mentions: In consequence, on the basis of the above results, FigureĀ 11 schematically illustrates the possible processes of photodynamic TiO2 Ws coating GA to induce the improvement in antitumor activity remarkably. Firstly, TiO2 Ws can efficiently uptake GA for the unique high-area properties of them. Secondly, nanocarrier drug composites have the dual functions: they act as drug carriers to deliver GA into cancer cells and function as TiO2 Ws under UV irradiation for PDT at the same time. With UV irradiation, TiO2 Ws can generate ROS, which can induce the apoptosis of cells. Therefore, TiO2 Ws can increase the intracellular concentration of GA dramatically and enhance the suppression of cancer cell proliferation. Meanwhile, the excellent photocatalytic activity of TiO2 Ws could enhance the proliferation suppression ability of GA on K562 cells, showing their great potential in PDT. Thus, TiO2 Ws exhibit an enormous potential in the application of cancer therapy.Figure 11


A new strategy for TiO2 whiskers mediated multi-mode cancer treatment.

Xu P, Wang R, Ouyang J, Chen B - Nanoscale Res Lett (2015)

Improvement in antitumor activity by photodynamic TiO2Ws loading GA. Schematic illustration of the possible mechanism of distinguished improvement in antitumor activity by photodynamic TiO2 Ws-loading GA.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4385221&req=5

Fig11: Improvement in antitumor activity by photodynamic TiO2Ws loading GA. Schematic illustration of the possible mechanism of distinguished improvement in antitumor activity by photodynamic TiO2 Ws-loading GA.
Mentions: In consequence, on the basis of the above results, FigureĀ 11 schematically illustrates the possible processes of photodynamic TiO2 Ws coating GA to induce the improvement in antitumor activity remarkably. Firstly, TiO2 Ws can efficiently uptake GA for the unique high-area properties of them. Secondly, nanocarrier drug composites have the dual functions: they act as drug carriers to deliver GA into cancer cells and function as TiO2 Ws under UV irradiation for PDT at the same time. With UV irradiation, TiO2 Ws can generate ROS, which can induce the apoptosis of cells. Therefore, TiO2 Ws can increase the intracellular concentration of GA dramatically and enhance the suppression of cancer cell proliferation. Meanwhile, the excellent photocatalytic activity of TiO2 Ws could enhance the proliferation suppression ability of GA on K562 cells, showing their great potential in PDT. Thus, TiO2 Ws exhibit an enormous potential in the application of cancer therapy.Figure 11

Bottom Line: Traditional Chinese medicine (TCM) which functions as chemotherapeutic or adjuvantly chemotherapeutic agents has been drawing a great many eyeballs for its easy obtain and significant antitumor effects accompanied with less toxic and side effects.These results identify TiO2 Ws of good biocompatibility and photocatalytic activity.These results reveal that such modality combinations put forward a promising proposal in cancer therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008 People's Republic of China.

ABSTRACT
Traditional Chinese medicine (TCM) which functions as chemotherapeutic or adjuvantly chemotherapeutic agents has been drawing a great many eyeballs for its easy obtain and significant antitumor effects accompanied with less toxic and side effects. PDT (photodynamic therapy) utilizes the fact that certain compounds coined as photosensitizers, when exposed to light of a specific wavelength, are capable of generating cytotoxic reactive oxygen species (ROS) such as hydroxyl radical, hydrogen peroxide, and superoxide to kill cancer cells. Combinations of cancer therapeutic modalities are studied to improve the efficacy of treatment. This study aimed to explore a new strategy of coupling of titanium dioxide whiskers (TiO2 Ws) with the anticancer drug gambogic acid (GA) in photodynamic therapy. The nanocomposites were coined as GA-TiO2. The combination of TiO2 Ws with GA induced a remarkable enhancement in antitumor activity estimated by MTT assay, nuclear DAPI staining, and flow cytometry. Furthermore, the possible signaling pathway was explored by reverse transcription polymerase chain reaction (RT-PCR) and Western blot assay. These results identify TiO2 Ws of good biocompatibility and photocatalytic activity. In human leukemia cells (K562 cells), TiO2 Ws could obviously increase the intracellular concentration of GA and enhance its potential antitumor efficiency, suggesting that TiO2 Ws could act as an efficient drug delivery carrier targeting GA to carcinoma cells. Moreover, photodynamic GA-TiO2 nanocomposites could induce an evident reinforcement in antitumor activity with UV illumination. These results reveal that such modality combinations put forward a promising proposal in cancer therapy.

No MeSH data available.


Related in: MedlinePlus