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MELK-a conserved kinase: functions, signaling, cancer, and controversy.

Ganguly R, Mohyeldin A, Thiel J, Kornblum HI, Beullens M, Nakano I - Clin Transl Med (2015)

Bottom Line: Maternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine kinase initially found to be expressed in a wide range of early embryonic cellular stages, and as a result has been implicated in embryogenesis and cell cycle control.Recent evidence has identified a broader spectrum of tissue expression pattern for this kinase than previously appreciated.Furthermore understanding MELK signaling may elucidate an added dimension of stem cell control.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurological Surgery, The Ohio State University, 385 Wiseman Hall, 410 W 12th St., 43210 Columbus, OH USA.

ABSTRACT
Maternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine kinase initially found to be expressed in a wide range of early embryonic cellular stages, and as a result has been implicated in embryogenesis and cell cycle control. Recent evidence has identified a broader spectrum of tissue expression pattern for this kinase than previously appreciated. MELK is expressed in several human cancers and stem cell populations. Unique spatial and temporal patterns of expression within these tissues suggest that MELK plays a prominent role in cell cycle control, cell proliferation, apoptosis, cell migration, cell renewal, embryogenesis, oncogenesis, and cancer treatment resistance and recurrence. These findings have important implications for our understanding of development, disease, and cancer therapeutics. Furthermore understanding MELK signaling may elucidate an added dimension of stem cell control.

No MeSH data available.


Related in: MedlinePlus

This schematic highlights many of the signaling pathways MELK is involved in. Upregulation of MELK drives cell cycle progression and tumor formation. Since many mysteries still surround MELK, more factors will likely be discovered to play a role in MELK regulation and signaling pathways.
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Fig2: This schematic highlights many of the signaling pathways MELK is involved in. Upregulation of MELK drives cell cycle progression and tumor formation. Since many mysteries still surround MELK, more factors will likely be discovered to play a role in MELK regulation and signaling pathways.

Mentions: Since the discovery of MELK, many signaling proteins and pathways that regulate the action of MELK have been discovered, some of which are highlighted in FigureĀ 2. Early biochemical analyses found that exogenously expressed murine MELK binds to the zinc-finger-like Zpr9, which results in the activation of the oncogenic transcription factor B-Myb in murine cell lines [38].Figure 2


MELK-a conserved kinase: functions, signaling, cancer, and controversy.

Ganguly R, Mohyeldin A, Thiel J, Kornblum HI, Beullens M, Nakano I - Clin Transl Med (2015)

This schematic highlights many of the signaling pathways MELK is involved in. Upregulation of MELK drives cell cycle progression and tumor formation. Since many mysteries still surround MELK, more factors will likely be discovered to play a role in MELK regulation and signaling pathways.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4385133&req=5

Fig2: This schematic highlights many of the signaling pathways MELK is involved in. Upregulation of MELK drives cell cycle progression and tumor formation. Since many mysteries still surround MELK, more factors will likely be discovered to play a role in MELK regulation and signaling pathways.
Mentions: Since the discovery of MELK, many signaling proteins and pathways that regulate the action of MELK have been discovered, some of which are highlighted in FigureĀ 2. Early biochemical analyses found that exogenously expressed murine MELK binds to the zinc-finger-like Zpr9, which results in the activation of the oncogenic transcription factor B-Myb in murine cell lines [38].Figure 2

Bottom Line: Maternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine kinase initially found to be expressed in a wide range of early embryonic cellular stages, and as a result has been implicated in embryogenesis and cell cycle control.Recent evidence has identified a broader spectrum of tissue expression pattern for this kinase than previously appreciated.Furthermore understanding MELK signaling may elucidate an added dimension of stem cell control.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurological Surgery, The Ohio State University, 385 Wiseman Hall, 410 W 12th St., 43210 Columbus, OH USA.

ABSTRACT
Maternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine kinase initially found to be expressed in a wide range of early embryonic cellular stages, and as a result has been implicated in embryogenesis and cell cycle control. Recent evidence has identified a broader spectrum of tissue expression pattern for this kinase than previously appreciated. MELK is expressed in several human cancers and stem cell populations. Unique spatial and temporal patterns of expression within these tissues suggest that MELK plays a prominent role in cell cycle control, cell proliferation, apoptosis, cell migration, cell renewal, embryogenesis, oncogenesis, and cancer treatment resistance and recurrence. These findings have important implications for our understanding of development, disease, and cancer therapeutics. Furthermore understanding MELK signaling may elucidate an added dimension of stem cell control.

No MeSH data available.


Related in: MedlinePlus