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Uveitic crystalline maculopathy.

Or C, Kirker AW, Forooghian F - J Ophthalmic Inflamm Infect (2015)

Bottom Line: A 52-year-old Japanese female presented with a 4-month history of decreased vision in the left eye.Dilated fundus examination of the right eye was unremarkable, but that of the left eye demonstrated foveal yellow-green intraretinal crystals and mild vitritis.There was no history or findings to suggest any cause for the crystals other than the uveitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology & Visual Sciences, Faculty of Medicine, Eye Care Centre, Vancouver General Hospital, University of British Columbia, 2550 Willow Street, Vancouver, BC V5Z 3N9 Canada.

ABSTRACT

Background: The purpose of this case report is to present a novel cause of crystalline maculopathy.

Findings: A 52-year-old Japanese female presented with a 4-month history of decreased vision in the left eye. Best corrected visual acuity in the left eye was 20/40. Dilated fundus examination of the right eye was unremarkable, but that of the left eye demonstrated foveal yellow-green intraretinal crystals and mild vitritis. Optical coherence tomography of the left eye revealed small intraretinal fluid cysts and intraretinal crystals. Ultra-widefield fluorescein angiography was normal in the right eye, but that of the left eye demonstrated features of intermediate uveitis. There was no history or findings to suggest any cause for the crystals other than the uveitis.

Conclusions: We propose that this may represent a novel category of crystalline retinopathy, termed uveitic crystalline maculopathy. We hypothesize that breakdown of the blood-retinal barrier as seen in uveitis may contribute to the deposition of crystals in the macula, although the precise composition of the crystals is unknown.

No MeSH data available.


Related in: MedlinePlus

Ultra-widefield fluorescein angiogram (UWFA) of the patient with uveitic crystalline maculopathy. UWFA of the right eye is normal (A). UWFA of the left eye revealed disc leakage, petaloid macular edema, and diffuse peripheral retinal leakage, consistent with intermediate uveitis (B).
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Fig3: Ultra-widefield fluorescein angiogram (UWFA) of the patient with uveitic crystalline maculopathy. UWFA of the right eye is normal (A). UWFA of the left eye revealed disc leakage, petaloid macular edema, and diffuse peripheral retinal leakage, consistent with intermediate uveitis (B).

Mentions: A 52-year-old Canadian-born Japanese female presented with a 4-month history of decreased vision of the left eye (OS). Past history revealed calcific rotator tendinopathy, which required two barbotage treatments. Best corrected visual acuity (BCVA) was 20/20 in the right (OD) and 20/40 OS. Intraocular pressure was 20 mmHg OD and 22 mmHg OS. Slit-lamp examination revealed posterior chamber intraocular lens implants bilaterally. Dilated fundal examination of the right eye was unremarkable, but that of the left eye demonstrated foveal yellow-green intraretinal crystals (Figure 1) and mild vitritis. OCT of the left eye revealed small intraretinal fluid cysts and intraretinal hyper-reflective lesions in Henle’s layer and inner nuclear layer, corresponding to the clinically observed crystals (Figure 2A,B,C). OCT of the right eye was normal. Ultra-widefield fluorescein angiography was normal in the right eye (Figure 3A), but that of the left eye showed disc leakage, petaloid macular edema, and diffuse peripheral retinal leakage (Figure 3B), consistent with intermediate uveitis. No peripheral retinal detachment, vascular telangiectasia, or retinal pigment epithelial abnormalities were observed in either eye.Figure 1


Uveitic crystalline maculopathy.

Or C, Kirker AW, Forooghian F - J Ophthalmic Inflamm Infect (2015)

Ultra-widefield fluorescein angiogram (UWFA) of the patient with uveitic crystalline maculopathy. UWFA of the right eye is normal (A). UWFA of the left eye revealed disc leakage, petaloid macular edema, and diffuse peripheral retinal leakage, consistent with intermediate uveitis (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384977&req=5

Fig3: Ultra-widefield fluorescein angiogram (UWFA) of the patient with uveitic crystalline maculopathy. UWFA of the right eye is normal (A). UWFA of the left eye revealed disc leakage, petaloid macular edema, and diffuse peripheral retinal leakage, consistent with intermediate uveitis (B).
Mentions: A 52-year-old Canadian-born Japanese female presented with a 4-month history of decreased vision of the left eye (OS). Past history revealed calcific rotator tendinopathy, which required two barbotage treatments. Best corrected visual acuity (BCVA) was 20/20 in the right (OD) and 20/40 OS. Intraocular pressure was 20 mmHg OD and 22 mmHg OS. Slit-lamp examination revealed posterior chamber intraocular lens implants bilaterally. Dilated fundal examination of the right eye was unremarkable, but that of the left eye demonstrated foveal yellow-green intraretinal crystals (Figure 1) and mild vitritis. OCT of the left eye revealed small intraretinal fluid cysts and intraretinal hyper-reflective lesions in Henle’s layer and inner nuclear layer, corresponding to the clinically observed crystals (Figure 2A,B,C). OCT of the right eye was normal. Ultra-widefield fluorescein angiography was normal in the right eye (Figure 3A), but that of the left eye showed disc leakage, petaloid macular edema, and diffuse peripheral retinal leakage (Figure 3B), consistent with intermediate uveitis. No peripheral retinal detachment, vascular telangiectasia, or retinal pigment epithelial abnormalities were observed in either eye.Figure 1

Bottom Line: A 52-year-old Japanese female presented with a 4-month history of decreased vision in the left eye.Dilated fundus examination of the right eye was unremarkable, but that of the left eye demonstrated foveal yellow-green intraretinal crystals and mild vitritis.There was no history or findings to suggest any cause for the crystals other than the uveitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology & Visual Sciences, Faculty of Medicine, Eye Care Centre, Vancouver General Hospital, University of British Columbia, 2550 Willow Street, Vancouver, BC V5Z 3N9 Canada.

ABSTRACT

Background: The purpose of this case report is to present a novel cause of crystalline maculopathy.

Findings: A 52-year-old Japanese female presented with a 4-month history of decreased vision in the left eye. Best corrected visual acuity in the left eye was 20/40. Dilated fundus examination of the right eye was unremarkable, but that of the left eye demonstrated foveal yellow-green intraretinal crystals and mild vitritis. Optical coherence tomography of the left eye revealed small intraretinal fluid cysts and intraretinal crystals. Ultra-widefield fluorescein angiography was normal in the right eye, but that of the left eye demonstrated features of intermediate uveitis. There was no history or findings to suggest any cause for the crystals other than the uveitis.

Conclusions: We propose that this may represent a novel category of crystalline retinopathy, termed uveitic crystalline maculopathy. We hypothesize that breakdown of the blood-retinal barrier as seen in uveitis may contribute to the deposition of crystals in the macula, although the precise composition of the crystals is unknown.

No MeSH data available.


Related in: MedlinePlus