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Human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility.

Liu X, Zhang H, Chang L, Yu B, Liu Q, Wu J, Miao Y, Ma P, Fan D, Fan H - Nanoscale Res Lett (2015)

Bottom Line: After coating of HLC, the sample shows a faster rate of temperature increase under an alternating magnetic field although it has a reduced saturation magnetization.In addition, compared with Fe3O4 nanoparticles before coating with HLC, HLC-coated Fe3O4 nanoparticles do not induce notable cytotoxic effect at higher concentration which indicates that HLC-coated Fe3O4 nanoparticles has improved biocompatibility.Our results clearly show that Fe3O4 nanoparticles after coating with HLC not only possess effective heat induction for cancer treatment but also have improved biocompatibility for biomedicine applications.

View Article: PubMed Central - PubMed

Affiliation: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069 China ; Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, Singapore, 117574 Singapore.

ABSTRACT
Human-like collagen (HLC)-coated monodispersed superparamagnetic Fe3O4 nanoparticles have been successfully prepared to investigate its effect on heat induction property and cell toxicity. After coating of HLC, the sample shows a faster rate of temperature increase under an alternating magnetic field although it has a reduced saturation magnetization. This is most probably a result of the effective heat conduction and good colloid stability due to the high charge of HLC on the surface. In addition, compared with Fe3O4 nanoparticles before coating with HLC, HLC-coated Fe3O4 nanoparticles do not induce notable cytotoxic effect at higher concentration which indicates that HLC-coated Fe3O4 nanoparticles has improved biocompatibility. Our results clearly show that Fe3O4 nanoparticles after coating with HLC not only possess effective heat induction for cancer treatment but also have improved biocompatibility for biomedicine applications.

No MeSH data available.


Related in: MedlinePlus

VSM characterization. The hysteresis loop of Fe3O4 NPs before (black cubic) and after (red circle) at room temperature.
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Fig5: VSM characterization. The hysteresis loop of Fe3O4 NPs before (black cubic) and after (red circle) at room temperature.

Mentions: For clinical application of HLC-coated Fe3O4 NPs as a high performance magnetic hyperthermia agent, it is critical that HLC-coated Fe3O4 NPs should maintain their magnetic properties after coating with HLC. The magnetic properties of HLC-coated Fe3O4 NPs were characterized by using a VSM. The Fe3O4 NPs exhibit superparamagnetic properties at room temperature before and after coating with HLC, with no coercivity and remanence. As shown in Figure 5, the saturation magnetizations (Ms) before and after coating with HLC are 46 and 40 emu/g, respectively. The reduced Ms after coating with HLC is mainly attributed to the decreased effective weight fraction of the magnetic core. However, since the variation of Ms was within 15%, this suggests that coating with HLC does not significantly change the magnetic properties.Figure 5


Human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility.

Liu X, Zhang H, Chang L, Yu B, Liu Q, Wu J, Miao Y, Ma P, Fan D, Fan H - Nanoscale Res Lett (2015)

VSM characterization. The hysteresis loop of Fe3O4 NPs before (black cubic) and after (red circle) at room temperature.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384969&req=5

Fig5: VSM characterization. The hysteresis loop of Fe3O4 NPs before (black cubic) and after (red circle) at room temperature.
Mentions: For clinical application of HLC-coated Fe3O4 NPs as a high performance magnetic hyperthermia agent, it is critical that HLC-coated Fe3O4 NPs should maintain their magnetic properties after coating with HLC. The magnetic properties of HLC-coated Fe3O4 NPs were characterized by using a VSM. The Fe3O4 NPs exhibit superparamagnetic properties at room temperature before and after coating with HLC, with no coercivity and remanence. As shown in Figure 5, the saturation magnetizations (Ms) before and after coating with HLC are 46 and 40 emu/g, respectively. The reduced Ms after coating with HLC is mainly attributed to the decreased effective weight fraction of the magnetic core. However, since the variation of Ms was within 15%, this suggests that coating with HLC does not significantly change the magnetic properties.Figure 5

Bottom Line: After coating of HLC, the sample shows a faster rate of temperature increase under an alternating magnetic field although it has a reduced saturation magnetization.In addition, compared with Fe3O4 nanoparticles before coating with HLC, HLC-coated Fe3O4 nanoparticles do not induce notable cytotoxic effect at higher concentration which indicates that HLC-coated Fe3O4 nanoparticles has improved biocompatibility.Our results clearly show that Fe3O4 nanoparticles after coating with HLC not only possess effective heat induction for cancer treatment but also have improved biocompatibility for biomedicine applications.

View Article: PubMed Central - PubMed

Affiliation: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069 China ; Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, Singapore, 117574 Singapore.

ABSTRACT
Human-like collagen (HLC)-coated monodispersed superparamagnetic Fe3O4 nanoparticles have been successfully prepared to investigate its effect on heat induction property and cell toxicity. After coating of HLC, the sample shows a faster rate of temperature increase under an alternating magnetic field although it has a reduced saturation magnetization. This is most probably a result of the effective heat conduction and good colloid stability due to the high charge of HLC on the surface. In addition, compared with Fe3O4 nanoparticles before coating with HLC, HLC-coated Fe3O4 nanoparticles do not induce notable cytotoxic effect at higher concentration which indicates that HLC-coated Fe3O4 nanoparticles has improved biocompatibility. Our results clearly show that Fe3O4 nanoparticles after coating with HLC not only possess effective heat induction for cancer treatment but also have improved biocompatibility for biomedicine applications.

No MeSH data available.


Related in: MedlinePlus