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Review of atrophic gastritis and intestinal metaplasia as a premalignant lesion of gastric cancer.

Park YH, Kim N - J Cancer Prev (2015)

Bottom Line: The prevalence of AG and IM vary depending on countries, even it represents diverse results in the same nation.Helicobacter pylori infection has been proved as the most important cause of AG and IM.However, the reversibility of AG and IM by eradication of H. pylori which was assumed to be certain by meta-analysis is; however, controversial now.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam.

ABSTRACT
Atrophic gastritis (AG) and intestinal metaplasia (IM) are the main precursor lesions of gastric cancer as the incidence of gastric cancer increases in the gastric mucosa involved with AG and IM. The prevalence of AG and IM vary depending on countries, even it represents diverse results in the same nation. Usually AG is antecedent of IM but the etiologies of AG and IM are not always the same. The sensitivity and specificity of diagnostic methods to detect AG and IM are different. Furthermore, the management strategy of AG and IM has not been established, yet. Helicobacter pylori infection has been proved as the most important cause of AG and IM. Thus the eradication of H. pylori is very important to prevent the progression to gastric cancer which is still placed in the high rank in morbidity and mortality among cancers. However, the reversibility of AG and IM by eradication of H. pylori which was assumed to be certain by meta-analysis is; however, controversial now. Therefore, the understanding and early diagnosis of AG and IM are very important, especially, in high incidence area of gastric cancer such as Republic of Korea.

No MeSH data available.


Related in: MedlinePlus

Gastritis staging: the OLGA system. Atrophy is defined as loss of appropriate glands (with or without metaplasia). In each compartment, atrophy is scored in a four-tiered scale (0–3) according to the visual analogue scale of the updated Sydney system. Adapted from Rugge et al.64
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f5-jcp-20-25: Gastritis staging: the OLGA system. Atrophy is defined as loss of appropriate glands (with or without metaplasia). In each compartment, atrophy is scored in a four-tiered scale (0–3) according to the visual analogue scale of the updated Sydney system. Adapted from Rugge et al.64

Mentions: The updated Sydney system is the most widely used classification of gastritis. However, it does not reflect prognosis of gastric cancer risk in subjects with CAG. Therefore, the Operative Link on Gastritis Assessment (OLGA) was developed to improve the histological staging system for gastric atrophy.64 OLGA system uses gastric biopsy sampling protocol defined by Sydney System and the histological grading system recommended by the updated Sydney System (Fig. 5).64 Long-term follow-up studies with follow-up ranges from 144 to 204 months proved that the OLGA staging reflects relevant information on clinic-pathological outcome of gastritis and therefore H. pylori negative patients with low OLGA stages could be excluded from secondary preventive surveillance of gastric cancer.65 Whereas patients with higher OLGA stages (Stages III and IV) should be considered definitely candidates for endoscopic examination.65 However, there are no universally acceptable classification methods for gastritis, yet. For the optimization of the methods to interpret the gastritis, repetitive communication between the endoscopists and pathologists should be required.


Review of atrophic gastritis and intestinal metaplasia as a premalignant lesion of gastric cancer.

Park YH, Kim N - J Cancer Prev (2015)

Gastritis staging: the OLGA system. Atrophy is defined as loss of appropriate glands (with or without metaplasia). In each compartment, atrophy is scored in a four-tiered scale (0–3) according to the visual analogue scale of the updated Sydney system. Adapted from Rugge et al.64
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384712&req=5

f5-jcp-20-25: Gastritis staging: the OLGA system. Atrophy is defined as loss of appropriate glands (with or without metaplasia). In each compartment, atrophy is scored in a four-tiered scale (0–3) according to the visual analogue scale of the updated Sydney system. Adapted from Rugge et al.64
Mentions: The updated Sydney system is the most widely used classification of gastritis. However, it does not reflect prognosis of gastric cancer risk in subjects with CAG. Therefore, the Operative Link on Gastritis Assessment (OLGA) was developed to improve the histological staging system for gastric atrophy.64 OLGA system uses gastric biopsy sampling protocol defined by Sydney System and the histological grading system recommended by the updated Sydney System (Fig. 5).64 Long-term follow-up studies with follow-up ranges from 144 to 204 months proved that the OLGA staging reflects relevant information on clinic-pathological outcome of gastritis and therefore H. pylori negative patients with low OLGA stages could be excluded from secondary preventive surveillance of gastric cancer.65 Whereas patients with higher OLGA stages (Stages III and IV) should be considered definitely candidates for endoscopic examination.65 However, there are no universally acceptable classification methods for gastritis, yet. For the optimization of the methods to interpret the gastritis, repetitive communication between the endoscopists and pathologists should be required.

Bottom Line: The prevalence of AG and IM vary depending on countries, even it represents diverse results in the same nation.Helicobacter pylori infection has been proved as the most important cause of AG and IM.However, the reversibility of AG and IM by eradication of H. pylori which was assumed to be certain by meta-analysis is; however, controversial now.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam.

ABSTRACT
Atrophic gastritis (AG) and intestinal metaplasia (IM) are the main precursor lesions of gastric cancer as the incidence of gastric cancer increases in the gastric mucosa involved with AG and IM. The prevalence of AG and IM vary depending on countries, even it represents diverse results in the same nation. Usually AG is antecedent of IM but the etiologies of AG and IM are not always the same. The sensitivity and specificity of diagnostic methods to detect AG and IM are different. Furthermore, the management strategy of AG and IM has not been established, yet. Helicobacter pylori infection has been proved as the most important cause of AG and IM. Thus the eradication of H. pylori is very important to prevent the progression to gastric cancer which is still placed in the high rank in morbidity and mortality among cancers. However, the reversibility of AG and IM by eradication of H. pylori which was assumed to be certain by meta-analysis is; however, controversial now. Therefore, the understanding and early diagnosis of AG and IM are very important, especially, in high incidence area of gastric cancer such as Republic of Korea.

No MeSH data available.


Related in: MedlinePlus