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Endocrine-disrupting Chemicals: Review of Toxicological Mechanisms Using Molecular Pathway Analysis.

Yang O, Kim HL, Weon JI, Seo YR - J Cancer Prev (2015)

Bottom Line: As importantly, numerous studies have demonstrated that the accumulation of endocrine disruptors can induce fatal disorders including obesity and cancer.Recently, pathway analysis, a bioinformatics tool, is being widely used to predict the potential mechanism or biological network of certain chemicals.The review emphasizes the importance of pathway analysis using bioinformatics to finding the specific mechanisms of toxic chemicals, including endocrine disruptors.

View Article: PubMed Central - PubMed

Affiliation: Department of Life Science, College of Life Sciences and Biotechnology, Dongguk University Biomedi Campus, Goyang ; Institute of Environmental Medicine, Dongguk University Biomedi Campus, Seoul.

ABSTRACT
Endocrine disruptors are known to cause harmful effects to human through various exposure routes. These chemicals mainly appear to interfere with the endocrine or hormone systems. As importantly, numerous studies have demonstrated that the accumulation of endocrine disruptors can induce fatal disorders including obesity and cancer. Using diverse biological tools, the potential molecular mechanisms related with these diseases by exposure of endocrine disruptors. Recently, pathway analysis, a bioinformatics tool, is being widely used to predict the potential mechanism or biological network of certain chemicals. In this review, we initially summarize the major molecular mechanisms involved in the induction of the above mentioned diseases by endocrine disruptors. Additionally, we provide the potential markers and signaling mechanisms discovered via pathway analysis under exposure to representative endocrine disruptors, bisphenol, diethylhexylphthalate, and nonylphenol. The review emphasizes the importance of pathway analysis using bioinformatics to finding the specific mechanisms of toxic chemicals, including endocrine disruptors.

No MeSH data available.


Related in: MedlinePlus

The related pathway of molecular/cellular process and disease/ disorder. (A) Bisphenol A. Included molecular/cellular process and diseases/disorders were collected from the relevant papers.57–60 (B) Phthalate. Included molecular/cellular process and diseases/disorders were collected from the relevant papers.61–75 (C) Nonylphenol. Included molecular/ cellular process and diseases/disorders were collected from the relevant papers.18,76–82 Each pathway was discovered using pathway analysis. Researchers can find the significant molecular and cellular pathway and compare and infer the correlation between the endocrine disruptors and the disease in terms of gene ontology. The pathway analysis can open up the possibility for more study. LEF1, lymphoid enhancer-binding factor 1; PPAR, proliferator activated receptor; ICF3, immunodeficiency-centromeric instability-facial anomalies syndrome 1.
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f3-jcp-20-12: The related pathway of molecular/cellular process and disease/ disorder. (A) Bisphenol A. Included molecular/cellular process and diseases/disorders were collected from the relevant papers.57–60 (B) Phthalate. Included molecular/cellular process and diseases/disorders were collected from the relevant papers.61–75 (C) Nonylphenol. Included molecular/ cellular process and diseases/disorders were collected from the relevant papers.18,76–82 Each pathway was discovered using pathway analysis. Researchers can find the significant molecular and cellular pathway and compare and infer the correlation between the endocrine disruptors and the disease in terms of gene ontology. The pathway analysis can open up the possibility for more study. LEF1, lymphoid enhancer-binding factor 1; PPAR, proliferator activated receptor; ICF3, immunodeficiency-centromeric instability-facial anomalies syndrome 1.

Mentions: Three chemicals are focused on in this review: BPA, NP and DEHP (Fig. 3).18,57–82 These chemicals are typical endocrine disruptors and also the numbers of studies are the most abundant. In fact, some government agencies take these three chemicals as representative substances of all the endocrine disruptors. Researches show these chemicals can disrupt reproductive and developmental systems, increase cancer risks and damage the immune systems of experimental laboratory animals.83


Endocrine-disrupting Chemicals: Review of Toxicological Mechanisms Using Molecular Pathway Analysis.

Yang O, Kim HL, Weon JI, Seo YR - J Cancer Prev (2015)

The related pathway of molecular/cellular process and disease/ disorder. (A) Bisphenol A. Included molecular/cellular process and diseases/disorders were collected from the relevant papers.57–60 (B) Phthalate. Included molecular/cellular process and diseases/disorders were collected from the relevant papers.61–75 (C) Nonylphenol. Included molecular/ cellular process and diseases/disorders were collected from the relevant papers.18,76–82 Each pathway was discovered using pathway analysis. Researchers can find the significant molecular and cellular pathway and compare and infer the correlation between the endocrine disruptors and the disease in terms of gene ontology. The pathway analysis can open up the possibility for more study. LEF1, lymphoid enhancer-binding factor 1; PPAR, proliferator activated receptor; ICF3, immunodeficiency-centromeric instability-facial anomalies syndrome 1.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384711&req=5

f3-jcp-20-12: The related pathway of molecular/cellular process and disease/ disorder. (A) Bisphenol A. Included molecular/cellular process and diseases/disorders were collected from the relevant papers.57–60 (B) Phthalate. Included molecular/cellular process and diseases/disorders were collected from the relevant papers.61–75 (C) Nonylphenol. Included molecular/ cellular process and diseases/disorders were collected from the relevant papers.18,76–82 Each pathway was discovered using pathway analysis. Researchers can find the significant molecular and cellular pathway and compare and infer the correlation between the endocrine disruptors and the disease in terms of gene ontology. The pathway analysis can open up the possibility for more study. LEF1, lymphoid enhancer-binding factor 1; PPAR, proliferator activated receptor; ICF3, immunodeficiency-centromeric instability-facial anomalies syndrome 1.
Mentions: Three chemicals are focused on in this review: BPA, NP and DEHP (Fig. 3).18,57–82 These chemicals are typical endocrine disruptors and also the numbers of studies are the most abundant. In fact, some government agencies take these three chemicals as representative substances of all the endocrine disruptors. Researches show these chemicals can disrupt reproductive and developmental systems, increase cancer risks and damage the immune systems of experimental laboratory animals.83

Bottom Line: As importantly, numerous studies have demonstrated that the accumulation of endocrine disruptors can induce fatal disorders including obesity and cancer.Recently, pathway analysis, a bioinformatics tool, is being widely used to predict the potential mechanism or biological network of certain chemicals.The review emphasizes the importance of pathway analysis using bioinformatics to finding the specific mechanisms of toxic chemicals, including endocrine disruptors.

View Article: PubMed Central - PubMed

Affiliation: Department of Life Science, College of Life Sciences and Biotechnology, Dongguk University Biomedi Campus, Goyang ; Institute of Environmental Medicine, Dongguk University Biomedi Campus, Seoul.

ABSTRACT
Endocrine disruptors are known to cause harmful effects to human through various exposure routes. These chemicals mainly appear to interfere with the endocrine or hormone systems. As importantly, numerous studies have demonstrated that the accumulation of endocrine disruptors can induce fatal disorders including obesity and cancer. Using diverse biological tools, the potential molecular mechanisms related with these diseases by exposure of endocrine disruptors. Recently, pathway analysis, a bioinformatics tool, is being widely used to predict the potential mechanism or biological network of certain chemicals. In this review, we initially summarize the major molecular mechanisms involved in the induction of the above mentioned diseases by endocrine disruptors. Additionally, we provide the potential markers and signaling mechanisms discovered via pathway analysis under exposure to representative endocrine disruptors, bisphenol, diethylhexylphthalate, and nonylphenol. The review emphasizes the importance of pathway analysis using bioinformatics to finding the specific mechanisms of toxic chemicals, including endocrine disruptors.

No MeSH data available.


Related in: MedlinePlus