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Endocrine-disrupting Chemicals: Review of Toxicological Mechanisms Using Molecular Pathway Analysis.

Yang O, Kim HL, Weon JI, Seo YR - J Cancer Prev (2015)

Bottom Line: As importantly, numerous studies have demonstrated that the accumulation of endocrine disruptors can induce fatal disorders including obesity and cancer.Recently, pathway analysis, a bioinformatics tool, is being widely used to predict the potential mechanism or biological network of certain chemicals.The review emphasizes the importance of pathway analysis using bioinformatics to finding the specific mechanisms of toxic chemicals, including endocrine disruptors.

View Article: PubMed Central - PubMed

Affiliation: Department of Life Science, College of Life Sciences and Biotechnology, Dongguk University Biomedi Campus, Goyang ; Institute of Environmental Medicine, Dongguk University Biomedi Campus, Seoul.

ABSTRACT
Endocrine disruptors are known to cause harmful effects to human through various exposure routes. These chemicals mainly appear to interfere with the endocrine or hormone systems. As importantly, numerous studies have demonstrated that the accumulation of endocrine disruptors can induce fatal disorders including obesity and cancer. Using diverse biological tools, the potential molecular mechanisms related with these diseases by exposure of endocrine disruptors. Recently, pathway analysis, a bioinformatics tool, is being widely used to predict the potential mechanism or biological network of certain chemicals. In this review, we initially summarize the major molecular mechanisms involved in the induction of the above mentioned diseases by endocrine disruptors. Additionally, we provide the potential markers and signaling mechanisms discovered via pathway analysis under exposure to representative endocrine disruptors, bisphenol, diethylhexylphthalate, and nonylphenol. The review emphasizes the importance of pathway analysis using bioinformatics to finding the specific mechanisms of toxic chemicals, including endocrine disruptors.

No MeSH data available.


Related in: MedlinePlus

Exposure sources and routes of endocrine disruptors in human. (A) Humans are exposed to endocrine disruptors directly or indirectly. Direct is through raw substance such as pharmaceutical including endocrine disruptors and phytoestrogens in plants. Indirect is exposure from foods treated with endocrine disruptors like pesticides and fungicides. (B) The major routes of human exposure. The fetus can be exposed by endocrine disruptors from the mother through the blood and breast milk. Cited from the article of Sharpe and Irvine (BMJ 2004;328:447–51) with original copyright holder’s permission.5
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f1-jcp-20-12: Exposure sources and routes of endocrine disruptors in human. (A) Humans are exposed to endocrine disruptors directly or indirectly. Direct is through raw substance such as pharmaceutical including endocrine disruptors and phytoestrogens in plants. Indirect is exposure from foods treated with endocrine disruptors like pesticides and fungicides. (B) The major routes of human exposure. The fetus can be exposed by endocrine disruptors from the mother through the blood and breast milk. Cited from the article of Sharpe and Irvine (BMJ 2004;328:447–51) with original copyright holder’s permission.5

Mentions: Food is the major route of exposure to endocrine disruptors (Fig. 1A). According to an article reported by Schecter et al.,2 a total of 32 food samples from three major supermarket chains in Dallas were contaminated with polybrominated diphenyl esters (PBDEs). In this study, PBDEs are detected mainly in fish, meat, and dairy products. BPA exposure also occurs through diet, including contaminated food and water.3


Endocrine-disrupting Chemicals: Review of Toxicological Mechanisms Using Molecular Pathway Analysis.

Yang O, Kim HL, Weon JI, Seo YR - J Cancer Prev (2015)

Exposure sources and routes of endocrine disruptors in human. (A) Humans are exposed to endocrine disruptors directly or indirectly. Direct is through raw substance such as pharmaceutical including endocrine disruptors and phytoestrogens in plants. Indirect is exposure from foods treated with endocrine disruptors like pesticides and fungicides. (B) The major routes of human exposure. The fetus can be exposed by endocrine disruptors from the mother through the blood and breast milk. Cited from the article of Sharpe and Irvine (BMJ 2004;328:447–51) with original copyright holder’s permission.5
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384711&req=5

f1-jcp-20-12: Exposure sources and routes of endocrine disruptors in human. (A) Humans are exposed to endocrine disruptors directly or indirectly. Direct is through raw substance such as pharmaceutical including endocrine disruptors and phytoestrogens in plants. Indirect is exposure from foods treated with endocrine disruptors like pesticides and fungicides. (B) The major routes of human exposure. The fetus can be exposed by endocrine disruptors from the mother through the blood and breast milk. Cited from the article of Sharpe and Irvine (BMJ 2004;328:447–51) with original copyright holder’s permission.5
Mentions: Food is the major route of exposure to endocrine disruptors (Fig. 1A). According to an article reported by Schecter et al.,2 a total of 32 food samples from three major supermarket chains in Dallas were contaminated with polybrominated diphenyl esters (PBDEs). In this study, PBDEs are detected mainly in fish, meat, and dairy products. BPA exposure also occurs through diet, including contaminated food and water.3

Bottom Line: As importantly, numerous studies have demonstrated that the accumulation of endocrine disruptors can induce fatal disorders including obesity and cancer.Recently, pathway analysis, a bioinformatics tool, is being widely used to predict the potential mechanism or biological network of certain chemicals.The review emphasizes the importance of pathway analysis using bioinformatics to finding the specific mechanisms of toxic chemicals, including endocrine disruptors.

View Article: PubMed Central - PubMed

Affiliation: Department of Life Science, College of Life Sciences and Biotechnology, Dongguk University Biomedi Campus, Goyang ; Institute of Environmental Medicine, Dongguk University Biomedi Campus, Seoul.

ABSTRACT
Endocrine disruptors are known to cause harmful effects to human through various exposure routes. These chemicals mainly appear to interfere with the endocrine or hormone systems. As importantly, numerous studies have demonstrated that the accumulation of endocrine disruptors can induce fatal disorders including obesity and cancer. Using diverse biological tools, the potential molecular mechanisms related with these diseases by exposure of endocrine disruptors. Recently, pathway analysis, a bioinformatics tool, is being widely used to predict the potential mechanism or biological network of certain chemicals. In this review, we initially summarize the major molecular mechanisms involved in the induction of the above mentioned diseases by endocrine disruptors. Additionally, we provide the potential markers and signaling mechanisms discovered via pathway analysis under exposure to representative endocrine disruptors, bisphenol, diethylhexylphthalate, and nonylphenol. The review emphasizes the importance of pathway analysis using bioinformatics to finding the specific mechanisms of toxic chemicals, including endocrine disruptors.

No MeSH data available.


Related in: MedlinePlus