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Celiac Disease in a Predisposed Subject (HLA-DQ2.5) with Coexisting Graves' Disease.

Hwang IK, Kim SH, Lee U, Chin SO, Rhee SY, Oh S, Woo JT, Kim SW, Kim YS, Chon S - Endocrinol Metab (Seoul) (2014)

Bottom Line: A 47-year-old woman complained of persistent chronic diarrhea and weight loss over a 9 month period.Results of all serological tests and stool exams were negative.However, the patient was found to carry the HLA DQ2 heterodimer.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.

ABSTRACT
Celiac disease is an intestinal autoimmune disorder, triggered by ingestion of a gluten-containing diet in genetically susceptible individuals. The genetic predisposition is related to human leukocyte antigen (HLA) class II genes, especially HLA-DQ2-positive patients. The prevalence of celiac disease has been estimated to be ~1% in Europe and the USA, but it is rarer and/or underdiagnosed in Asia. We report a case of celiac disease in a predisposed patient, with a HLA-DQ2 heterodimer, and Graves' disease that was treated successfully with a gluten-free diet. A 47-year-old woman complained of persistent chronic diarrhea and weight loss over a 9 month period. Results of all serological tests and stool exams were negative. However, the patient was found to carry the HLA DQ2 heterodimer. Symptoms improved after a gluten-free diet was initiated. The patient has been followed and has suffered no recurrence of symptoms while on the gluten-free diet. An overall diagnosis of celiac disease was made in a genetically predisposed patient (HLA-DQ2 heterodimer) with Graves' disease.

No MeSH data available.


Related in: MedlinePlus

Pathological findings from the duodenal endoscopic biopsy showed no significant villous atrophy, but a partial increase in intraepithelial lymphocytes was observed (H&E stain, ×400).
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Figure 3: Pathological findings from the duodenal endoscopic biopsy showed no significant villous atrophy, but a partial increase in intraepithelial lymphocytes was observed (H&E stain, ×400).

Mentions: Abdominal computed tomography scan showed no ascites or enlarged lymph nodes, and no edema or masses were observed in the small intestine (Fig. 1). Esophagogastroduodenoscopy showed no abnormal findings in the duodenal bulb (Fig. 2). Colonoscopy showed no gross abnormal finding in the colonic mucosa. The patient also underwent 'random' biopsies. A random biopsy of the colon showed normal variation. A duodenal bulb biopsy showed no significant villous atrophy, but a slight increase in intraepithelial lymphocytes was seen (Fig. 3).


Celiac Disease in a Predisposed Subject (HLA-DQ2.5) with Coexisting Graves' Disease.

Hwang IK, Kim SH, Lee U, Chin SO, Rhee SY, Oh S, Woo JT, Kim SW, Kim YS, Chon S - Endocrinol Metab (Seoul) (2014)

Pathological findings from the duodenal endoscopic biopsy showed no significant villous atrophy, but a partial increase in intraepithelial lymphocytes was observed (H&E stain, ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384671&req=5

Figure 3: Pathological findings from the duodenal endoscopic biopsy showed no significant villous atrophy, but a partial increase in intraepithelial lymphocytes was observed (H&E stain, ×400).
Mentions: Abdominal computed tomography scan showed no ascites or enlarged lymph nodes, and no edema or masses were observed in the small intestine (Fig. 1). Esophagogastroduodenoscopy showed no abnormal findings in the duodenal bulb (Fig. 2). Colonoscopy showed no gross abnormal finding in the colonic mucosa. The patient also underwent 'random' biopsies. A random biopsy of the colon showed normal variation. A duodenal bulb biopsy showed no significant villous atrophy, but a slight increase in intraepithelial lymphocytes was seen (Fig. 3).

Bottom Line: A 47-year-old woman complained of persistent chronic diarrhea and weight loss over a 9 month period.Results of all serological tests and stool exams were negative.However, the patient was found to carry the HLA DQ2 heterodimer.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.

ABSTRACT
Celiac disease is an intestinal autoimmune disorder, triggered by ingestion of a gluten-containing diet in genetically susceptible individuals. The genetic predisposition is related to human leukocyte antigen (HLA) class II genes, especially HLA-DQ2-positive patients. The prevalence of celiac disease has been estimated to be ~1% in Europe and the USA, but it is rarer and/or underdiagnosed in Asia. We report a case of celiac disease in a predisposed patient, with a HLA-DQ2 heterodimer, and Graves' disease that was treated successfully with a gluten-free diet. A 47-year-old woman complained of persistent chronic diarrhea and weight loss over a 9 month period. Results of all serological tests and stool exams were negative. However, the patient was found to carry the HLA DQ2 heterodimer. Symptoms improved after a gluten-free diet was initiated. The patient has been followed and has suffered no recurrence of symptoms while on the gluten-free diet. An overall diagnosis of celiac disease was made in a genetically predisposed patient (HLA-DQ2 heterodimer) with Graves' disease.

No MeSH data available.


Related in: MedlinePlus