Limits...
Effect of B vitamin (folate, B6, and B12) supplementation on osteoporotic fracture and bone turnover markers: a meta-analysis.

Ruan J, Gong X, Kong J, Wang H, Zheng X, Chen T - Med. Sci. Monit. (2015)

Bottom Line: Based on the results of 4 RCTs, this meta-analysis failed to identify a risk-reducing effect of daily supplementation of B vitamins on osteoporotic fracture in patients with vascular disease and with relatively normal plasma Hcy.In addition, we also did not find any positive effects of B vitamin supplementation on bone turnover.However, the possible benefits in selective populations, such as populations with very high plasma Hcy and from regions without B vitamin fortification should be explored in the future.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Taizhou Municpal Hospital, Taizhou, Zhejiang, China (mainland).

ABSTRACT

Background: B vitamins (including folate, B6, and B12) supplementation can effectively and easily modify high plasma homocysteine (Hcy). However, the role of Hcy in the pathogenesis of osteoporotic fracture and bone turnover is still controversial. This meta-analysis aimed to assess the impact of B vitamin supplementation on occurrence of any osteoporotic fracture and bone turnover by pooling the results of previous studies.

Material and methods: Relevant randomized controlled trials (RCTs) were searched in databases. Data integration and analysis were done by using Review Manager 5.3 (the Cochrane Collaboration). The risk ratio (RR) and corresponding 95% confidence intervals (CI) of fracture (intervention vs. control) were estimated. Changes in bone turnover indicators (continuous data), weighted mean difference (WMD), and corresponding 95% (CI) were pooled for estimation.

Results: Based on the results of 4 RCTs, this meta-analysis failed to identify a risk-reducing effect of daily supplementation of B vitamins on osteoporotic fracture in patients with vascular disease and with relatively normal plasma Hcy. In addition, we also did not find any positive effects of B vitamin supplementation on bone turnover.

Conclusions: B vitamin supplementation might not be effective in preventing fracture and improving bone turnover. However, the possible benefits in selective populations, such as populations with very high plasma Hcy and from regions without B vitamin fortification should be explored in the future.

Show MeSH

Related in: MedlinePlus

The searching and screening process.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4384513&req=5

f1-medscimonit-21-875: The searching and screening process.

Mentions: Based on searching in the database by using the preset selection criteria, eight RCTs involving 26,707 participants were finally included in this meta-analysis. The overall searching and screening process is described in Figure 1. Quality assessment of the studies is summarized in Figure 2. Generally, the quality of the 8 RCTs was high. Only 2 studies did not have blind design [13,14]. The key characteristics of the trials were summarized in Table 1. Four RCTs assessed the effect of B vitamin supplementation on fracture risk [15–18] and 4 RCTs assessed the change of bone formation markers after B vitamin supplementation [13,14,19,20]. All of the studies reported significantly lowered plasma Hcy in the intervention group than in the control group.


Effect of B vitamin (folate, B6, and B12) supplementation on osteoporotic fracture and bone turnover markers: a meta-analysis.

Ruan J, Gong X, Kong J, Wang H, Zheng X, Chen T - Med. Sci. Monit. (2015)

The searching and screening process.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4384513&req=5

f1-medscimonit-21-875: The searching and screening process.
Mentions: Based on searching in the database by using the preset selection criteria, eight RCTs involving 26,707 participants were finally included in this meta-analysis. The overall searching and screening process is described in Figure 1. Quality assessment of the studies is summarized in Figure 2. Generally, the quality of the 8 RCTs was high. Only 2 studies did not have blind design [13,14]. The key characteristics of the trials were summarized in Table 1. Four RCTs assessed the effect of B vitamin supplementation on fracture risk [15–18] and 4 RCTs assessed the change of bone formation markers after B vitamin supplementation [13,14,19,20]. All of the studies reported significantly lowered plasma Hcy in the intervention group than in the control group.

Bottom Line: Based on the results of 4 RCTs, this meta-analysis failed to identify a risk-reducing effect of daily supplementation of B vitamins on osteoporotic fracture in patients with vascular disease and with relatively normal plasma Hcy.In addition, we also did not find any positive effects of B vitamin supplementation on bone turnover.However, the possible benefits in selective populations, such as populations with very high plasma Hcy and from regions without B vitamin fortification should be explored in the future.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Taizhou Municpal Hospital, Taizhou, Zhejiang, China (mainland).

ABSTRACT

Background: B vitamins (including folate, B6, and B12) supplementation can effectively and easily modify high plasma homocysteine (Hcy). However, the role of Hcy in the pathogenesis of osteoporotic fracture and bone turnover is still controversial. This meta-analysis aimed to assess the impact of B vitamin supplementation on occurrence of any osteoporotic fracture and bone turnover by pooling the results of previous studies.

Material and methods: Relevant randomized controlled trials (RCTs) were searched in databases. Data integration and analysis were done by using Review Manager 5.3 (the Cochrane Collaboration). The risk ratio (RR) and corresponding 95% confidence intervals (CI) of fracture (intervention vs. control) were estimated. Changes in bone turnover indicators (continuous data), weighted mean difference (WMD), and corresponding 95% (CI) were pooled for estimation.

Results: Based on the results of 4 RCTs, this meta-analysis failed to identify a risk-reducing effect of daily supplementation of B vitamins on osteoporotic fracture in patients with vascular disease and with relatively normal plasma Hcy. In addition, we also did not find any positive effects of B vitamin supplementation on bone turnover.

Conclusions: B vitamin supplementation might not be effective in preventing fracture and improving bone turnover. However, the possible benefits in selective populations, such as populations with very high plasma Hcy and from regions without B vitamin fortification should be explored in the future.

Show MeSH
Related in: MedlinePlus