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The importance of loop length on the stability of i-motif structures.

Gurung SP, Schwarz C, Hall JP, Cardin CJ, Brazier JA - Chem. Commun. (Camb.) (2015)

Bottom Line: Using UV and srCD spectroscopy it is found that loop length within the i-motif structure is important for both thermal and pH stability, but in contrast to previous statements, it is the shorter loops that exhibit the highest stability.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Reading, Whiteknights, Reading, Berks RG6 6AD, UK.

ABSTRACT
Using UV and srCD spectroscopy it is found that loop length within the i-motif structure is important for both thermal and pH stability, but in contrast to previous statements, it is the shorter loops that exhibit the highest stability.

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Normalised absorbance at 260 nm versus (a) pH and (b) temperature.
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fig4: Normalised absorbance at 260 nm versus (a) pH and (b) temperature.

Mentions: ‡srCD spectra were collected on B23 at Diamond Light Source.


The importance of loop length on the stability of i-motif structures.

Gurung SP, Schwarz C, Hall JP, Cardin CJ, Brazier JA - Chem. Commun. (Camb.) (2015)

Normalised absorbance at 260 nm versus (a) pH and (b) temperature.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384421&req=5

fig4: Normalised absorbance at 260 nm versus (a) pH and (b) temperature.
Mentions: ‡srCD spectra were collected on B23 at Diamond Light Source.

Bottom Line: Using UV and srCD spectroscopy it is found that loop length within the i-motif structure is important for both thermal and pH stability, but in contrast to previous statements, it is the shorter loops that exhibit the highest stability.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Reading, Whiteknights, Reading, Berks RG6 6AD, UK.

ABSTRACT
Using UV and srCD spectroscopy it is found that loop length within the i-motif structure is important for both thermal and pH stability, but in contrast to previous statements, it is the shorter loops that exhibit the highest stability.

Show MeSH