Limits...
Comparison of etomidate and propofol on intubating conditions and the onset time associated with cisatracurium administration.

Ko YK, Kim YH, Park SI, Chung WS, Noh C, Lee JU - Korean J Anesthesiol (2015)

Bottom Line: This study compared intubating conditions and the onset time associated with administration of cisatracurium, a nondepolarizing neuromuscular blocker with a relatively slow onset, according to prior injection of one of two intravenous anesthetic agents: propofol or etomidate.The average onset time of cisatracurium was more rapid in group E (155.74 ± 32.92 s vs. 185.26 ± 38.57 s in group P; P = 0.008).Etomidate improves intubating conditions and provide a more rapid onset time of cisatracurium during anesthetic induction compared to propofol.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Chungnam National University College of Medicine, Daejeon, Korea.

ABSTRACT

Background: This study compared intubating conditions and the onset time associated with administration of cisatracurium, a nondepolarizing neuromuscular blocker with a relatively slow onset, according to prior injection of one of two intravenous anesthetic agents: propofol or etomidate.

Methods: Forty-six female patients, undergoing general anesthesia and endotracheal intubation for elective surgery, were randomized to two groups; group P were administered propofol (2 mg/kg) prior to cisatracurium (0.2 mg/kg); group E were administered etomidate (0.3 mg/kg) prior to cisatracurium (0.2 mg/kg). We measured intubating conditions and the onset time according to the types of intravenous anesthetic administered. Measurements of heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were taken immediately prior to induction; immediately and 1 min after IV anesthetic administration; and immediately and 1, 2, 3, 4, 5, 7, and 15 min after endotracheal intubation.

Results: Intubating conditions were superior in group E compared with group P (P = 0.009). The average onset time of cisatracurium was more rapid in group E (155.74 ± 32.92 s vs. 185.26 ± 38.57 s in group P; P = 0.008). There were no group differences in SBP, DBP, and HR following intravenous anesthetic drug injection and endotracheal intubation. However, SBP and DBP were substantially higher in group E after endotracheal intubation.

Conclusions: Etomidate improves intubating conditions and provide a more rapid onset time of cisatracurium during anesthetic induction compared to propofol.

No MeSH data available.


Related in: MedlinePlus

Changes in diastolic arterial pressure in each group during induction. Values are mean ± SD. There were no significant group differences (P > 0.05). Group P: received propofol (2 mg/kg); group E: received etomidate (0.3 mg/kg). B: baseline, I0: immediately after IV anesthetics, I1: 1 min after IV anesthetics, T0: immediately after endotracheal intubation, T1: 1 min after endotracheal intubation, T2: 2 min after endotracheal intubation, T3: 3 min after endotracheal intubation, T4: 4 min after endotracheal intubation, T5: 5 min after endotracheal intubation, T7: 7 min after endotracheal intubation, T15: 15 min after endotracheal intubation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4384400&req=5

Figure 2: Changes in diastolic arterial pressure in each group during induction. Values are mean ± SD. There were no significant group differences (P > 0.05). Group P: received propofol (2 mg/kg); group E: received etomidate (0.3 mg/kg). B: baseline, I0: immediately after IV anesthetics, I1: 1 min after IV anesthetics, T0: immediately after endotracheal intubation, T1: 1 min after endotracheal intubation, T2: 2 min after endotracheal intubation, T3: 3 min after endotracheal intubation, T4: 4 min after endotracheal intubation, T5: 5 min after endotracheal intubation, T7: 7 min after endotracheal intubation, T15: 15 min after endotracheal intubation.

Mentions: There were no group differences in SBP, DBP, and HR following intravenous anesthetic drug injection and endotracheal intubation (Figs. 1, 2 and 3). However, SBP and DBP were substantially higher in group E following endotracheal intubation. The BIS screens during anesthetic induction did not differ between the groups.


Comparison of etomidate and propofol on intubating conditions and the onset time associated with cisatracurium administration.

Ko YK, Kim YH, Park SI, Chung WS, Noh C, Lee JU - Korean J Anesthesiol (2015)

Changes in diastolic arterial pressure in each group during induction. Values are mean ± SD. There were no significant group differences (P > 0.05). Group P: received propofol (2 mg/kg); group E: received etomidate (0.3 mg/kg). B: baseline, I0: immediately after IV anesthetics, I1: 1 min after IV anesthetics, T0: immediately after endotracheal intubation, T1: 1 min after endotracheal intubation, T2: 2 min after endotracheal intubation, T3: 3 min after endotracheal intubation, T4: 4 min after endotracheal intubation, T5: 5 min after endotracheal intubation, T7: 7 min after endotracheal intubation, T15: 15 min after endotracheal intubation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384400&req=5

Figure 2: Changes in diastolic arterial pressure in each group during induction. Values are mean ± SD. There were no significant group differences (P > 0.05). Group P: received propofol (2 mg/kg); group E: received etomidate (0.3 mg/kg). B: baseline, I0: immediately after IV anesthetics, I1: 1 min after IV anesthetics, T0: immediately after endotracheal intubation, T1: 1 min after endotracheal intubation, T2: 2 min after endotracheal intubation, T3: 3 min after endotracheal intubation, T4: 4 min after endotracheal intubation, T5: 5 min after endotracheal intubation, T7: 7 min after endotracheal intubation, T15: 15 min after endotracheal intubation.
Mentions: There were no group differences in SBP, DBP, and HR following intravenous anesthetic drug injection and endotracheal intubation (Figs. 1, 2 and 3). However, SBP and DBP were substantially higher in group E following endotracheal intubation. The BIS screens during anesthetic induction did not differ between the groups.

Bottom Line: This study compared intubating conditions and the onset time associated with administration of cisatracurium, a nondepolarizing neuromuscular blocker with a relatively slow onset, according to prior injection of one of two intravenous anesthetic agents: propofol or etomidate.The average onset time of cisatracurium was more rapid in group E (155.74 ± 32.92 s vs. 185.26 ± 38.57 s in group P; P = 0.008).Etomidate improves intubating conditions and provide a more rapid onset time of cisatracurium during anesthetic induction compared to propofol.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Chungnam National University College of Medicine, Daejeon, Korea.

ABSTRACT

Background: This study compared intubating conditions and the onset time associated with administration of cisatracurium, a nondepolarizing neuromuscular blocker with a relatively slow onset, according to prior injection of one of two intravenous anesthetic agents: propofol or etomidate.

Methods: Forty-six female patients, undergoing general anesthesia and endotracheal intubation for elective surgery, were randomized to two groups; group P were administered propofol (2 mg/kg) prior to cisatracurium (0.2 mg/kg); group E were administered etomidate (0.3 mg/kg) prior to cisatracurium (0.2 mg/kg). We measured intubating conditions and the onset time according to the types of intravenous anesthetic administered. Measurements of heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were taken immediately prior to induction; immediately and 1 min after IV anesthetic administration; and immediately and 1, 2, 3, 4, 5, 7, and 15 min after endotracheal intubation.

Results: Intubating conditions were superior in group E compared with group P (P = 0.009). The average onset time of cisatracurium was more rapid in group E (155.74 ± 32.92 s vs. 185.26 ± 38.57 s in group P; P = 0.008). There were no group differences in SBP, DBP, and HR following intravenous anesthetic drug injection and endotracheal intubation. However, SBP and DBP were substantially higher in group E after endotracheal intubation.

Conclusions: Etomidate improves intubating conditions and provide a more rapid onset time of cisatracurium during anesthetic induction compared to propofol.

No MeSH data available.


Related in: MedlinePlus