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Effects of intravenously administered indocyanine green on near-infrared cerebral oximetry and pulse oximetry readings.

Baek HY, Lee HJ, Kim JM, Cho SY, Jeong S, Yoo KY - Korean J Anesthesiol (2015)

Bottom Line: In contrast, SpO2 was decreased in both groups; the magnitude of the decrease was greater in the 25 mg group than in the 12.5 mg group (4.0 ± 0.8% vs. 1.6 ± 1.0%, P < 0.0001).There were no differences in the time to reach the peak SctO2 or to reach the nadir SpO2 between the two groups.In patients given ICG for videoangiography, a 25 mg bolus results in a greater and more prolonged increase in SctO2 and a greater reduction in SpO2 than a 12.5 mg bolus, with no differences in the time to reach the peak SctO2 or to reach the nadir SpO2.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital, Gwangju, Korea.

ABSTRACT

Background: Intravenously administered indocyanine green (ICG) may cause misreadings of cerebral oximetry and pulse oximetry in patients undergoing carotid endarterectomy under general anesthesia. The present study determined the effects of two different doses (12.5 mg vs. 25 mg) of ICG on regional cerebral tissue oxygen saturation (SctO2) and percutaneous peripheral oxygen saturation (SpO2).

Methods: Twenty-six patients receiving ICG for videoangiography were divided into two groups according to the dosage (12.5 mg and 25 mg, n = 13 in each group). Heart rate, arterial blood pressure, SctO2, and SpO2 were measured before and after an intravenous bolus administration of ICG.

Results: Following the dye administration, no changes in heart rate or arterial blood pressure were noted in either group. SctO2 was increased in both groups; however, the magnitude of the increase was greater (21.6 ± 5.8% vs. 12.6 ± 4.1%, P < 0.0001) and more prolonged (28.4 ± 9.6 min vs. 13.8 ± 5.2 min, P < 0.0001) in the 25 mg group than in the 12.5 mg group. In contrast, SpO2 was decreased in both groups; the magnitude of the decrease was greater in the 25 mg group than in the 12.5 mg group (4.0 ± 0.8% vs. 1.6 ± 1.0%, P < 0.0001). There were no differences in the time to reach the peak SctO2 or to reach the nadir SpO2 between the two groups.

Conclusions: In patients given ICG for videoangiography, a 25 mg bolus results in a greater and more prolonged increase in SctO2 and a greater reduction in SpO2 than a 12.5 mg bolus, with no differences in the time to reach the peak SctO2 or to reach the nadir SpO2.

No MeSH data available.


Related in: MedlinePlus

The magnitude (ΔSctO2) and duration of the increase in regional cerebral oxygen saturation (SctO2) via cerebral oximetry after intravenous indocyanine green injection as a bolus (12.5 mg or 25 mg). Data shown are expressed as mean ± SD. *P < 0.05 vs. 12.5 mg.
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Figure 2: The magnitude (ΔSctO2) and duration of the increase in regional cerebral oxygen saturation (SctO2) via cerebral oximetry after intravenous indocyanine green injection as a bolus (12.5 mg or 25 mg). Data shown are expressed as mean ± SD. *P < 0.05 vs. 12.5 mg.

Mentions: Fig. 1 illustrates the typical changes in SctO2 after a 25 mg bolus injection of ICG in a patient by replicating the INVOS monitor display. Following the administration, SctO2 was significantly increased in both groups; however, the magnitude of the increase of was greater (21.6 ± 5.8% vs. 12.6 ± 4.1%, P < 0.0001) and more prolonged (28.4 ± 9.6 min vs. 13.8 ± 5.2 min, P < 0.0001) in the 25 mg group than in the 12.5 mg group (Fig. 2). No differences were noted between the two groups in the time to reach the greatest changes in SctO2 (43.0 ± 10.9 s vs. 50.0 ± 30.0 s, P = 0.437). Also, there were no significant differences in the degree of maximum increases in SctO2 between the non-operative and operative sides in either the 12.5 mg group (12.6 ± 4.1% vs. 12.7 ± 3.4%, P = 0.910) or the 25 mg group (21.6 ± 5.8% vs. 19.7 ± 3.6%, P = 0.054).


Effects of intravenously administered indocyanine green on near-infrared cerebral oximetry and pulse oximetry readings.

Baek HY, Lee HJ, Kim JM, Cho SY, Jeong S, Yoo KY - Korean J Anesthesiol (2015)

The magnitude (ΔSctO2) and duration of the increase in regional cerebral oxygen saturation (SctO2) via cerebral oximetry after intravenous indocyanine green injection as a bolus (12.5 mg or 25 mg). Data shown are expressed as mean ± SD. *P < 0.05 vs. 12.5 mg.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384398&req=5

Figure 2: The magnitude (ΔSctO2) and duration of the increase in regional cerebral oxygen saturation (SctO2) via cerebral oximetry after intravenous indocyanine green injection as a bolus (12.5 mg or 25 mg). Data shown are expressed as mean ± SD. *P < 0.05 vs. 12.5 mg.
Mentions: Fig. 1 illustrates the typical changes in SctO2 after a 25 mg bolus injection of ICG in a patient by replicating the INVOS monitor display. Following the administration, SctO2 was significantly increased in both groups; however, the magnitude of the increase of was greater (21.6 ± 5.8% vs. 12.6 ± 4.1%, P < 0.0001) and more prolonged (28.4 ± 9.6 min vs. 13.8 ± 5.2 min, P < 0.0001) in the 25 mg group than in the 12.5 mg group (Fig. 2). No differences were noted between the two groups in the time to reach the greatest changes in SctO2 (43.0 ± 10.9 s vs. 50.0 ± 30.0 s, P = 0.437). Also, there were no significant differences in the degree of maximum increases in SctO2 between the non-operative and operative sides in either the 12.5 mg group (12.6 ± 4.1% vs. 12.7 ± 3.4%, P = 0.910) or the 25 mg group (21.6 ± 5.8% vs. 19.7 ± 3.6%, P = 0.054).

Bottom Line: In contrast, SpO2 was decreased in both groups; the magnitude of the decrease was greater in the 25 mg group than in the 12.5 mg group (4.0 ± 0.8% vs. 1.6 ± 1.0%, P < 0.0001).There were no differences in the time to reach the peak SctO2 or to reach the nadir SpO2 between the two groups.In patients given ICG for videoangiography, a 25 mg bolus results in a greater and more prolonged increase in SctO2 and a greater reduction in SpO2 than a 12.5 mg bolus, with no differences in the time to reach the peak SctO2 or to reach the nadir SpO2.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital, Gwangju, Korea.

ABSTRACT

Background: Intravenously administered indocyanine green (ICG) may cause misreadings of cerebral oximetry and pulse oximetry in patients undergoing carotid endarterectomy under general anesthesia. The present study determined the effects of two different doses (12.5 mg vs. 25 mg) of ICG on regional cerebral tissue oxygen saturation (SctO2) and percutaneous peripheral oxygen saturation (SpO2).

Methods: Twenty-six patients receiving ICG for videoangiography were divided into two groups according to the dosage (12.5 mg and 25 mg, n = 13 in each group). Heart rate, arterial blood pressure, SctO2, and SpO2 were measured before and after an intravenous bolus administration of ICG.

Results: Following the dye administration, no changes in heart rate or arterial blood pressure were noted in either group. SctO2 was increased in both groups; however, the magnitude of the increase was greater (21.6 ± 5.8% vs. 12.6 ± 4.1%, P < 0.0001) and more prolonged (28.4 ± 9.6 min vs. 13.8 ± 5.2 min, P < 0.0001) in the 25 mg group than in the 12.5 mg group. In contrast, SpO2 was decreased in both groups; the magnitude of the decrease was greater in the 25 mg group than in the 12.5 mg group (4.0 ± 0.8% vs. 1.6 ± 1.0%, P < 0.0001). There were no differences in the time to reach the peak SctO2 or to reach the nadir SpO2 between the two groups.

Conclusions: In patients given ICG for videoangiography, a 25 mg bolus results in a greater and more prolonged increase in SctO2 and a greater reduction in SpO2 than a 12.5 mg bolus, with no differences in the time to reach the peak SctO2 or to reach the nadir SpO2.

No MeSH data available.


Related in: MedlinePlus