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Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST).

Kramer K, Knippschild U, Mayer B, Bögelspacher K, Spatz H, Henne-Bruns D, Agaimy A, Schwab M, Schmieder M - BMC Cancer (2015)

Bottom Line: DSS was significantly more favorable in younger female GIST patients compared with elderly females (p = 0.008).Female gender resulted again in better prognosis in younger patients (p = 0.033).Extended studies are warranted to confirm our clinical results and to elucidate underlying pathophysiological mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Department of General and Visceral Surgery, University Hospital Ulm, Albert-Einstein-Allee 23, Ulm, 89081, Germany. klaus.kramer@uniklinik-ulm.de.

ABSTRACT

Background: Risk classification and prediction of prognosis in GIST is still a matter of debate. Data on the impact of age and gender as potential confounding factors are limited. Therefore we comprehensively investigated age and gender as independent risk factors for GIST.

Methods: Two independent patient cohorts (cohort I, n = 87 [<50 years]; cohort II, n = 125 [≥50 years]) were extracted from the multicentre Ulmer GIST registry including a total of 659 GIST patients retrospectively collected in 18 collaborative German oncological centers. Based on demographic and clinicopathological parameters and a median follow-up time of 4.3 years (range 0.56; 21.33) disease-specific-survival (DSS), disease-free-survival (DFS) and overall survival (OS) were calculated.

Results: GIST patients older than fifty years showed significantly worse DSS compared to younger patients (p = 0.021; HR = 0.307, 95% CI [0.113; 0.834]). DSS was significantly more favorable in younger female GIST patients compared with elderly females (p = 0.008). Female gender resulted again in better prognosis in younger patients (p = 0.033).

Conclusions: Patient age (<50 years) and female gender were significantly associated with a more favourable prognosis in GIST. Extended studies are warranted to confirm our clinical results and to elucidate underlying pathophysiological mechanisms.

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Age and gender related outcome regarding OS. (A) Kaplan–Meier curves of overall survival (OS) for GIST patients of study cohort I (<50 years at diagnosis) versus study cohort II (≥50 years at diagnosis). (B) Kaplan–Meier curves of overall survival (OS) for female GIST patients of study cohort I (<50 years at diagnosis) versus study cohort II (≥50 years at diagnosis).
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Fig4: Age and gender related outcome regarding OS. (A) Kaplan–Meier curves of overall survival (OS) for GIST patients of study cohort I (<50 years at diagnosis) versus study cohort II (≥50 years at diagnosis). (B) Kaplan–Meier curves of overall survival (OS) for female GIST patients of study cohort I (<50 years at diagnosis) versus study cohort II (≥50 years at diagnosis).

Mentions: OS-rates were compared after 1-, 3- and 5-year follow up between sub-cohort I (98.5%, 93.2% and 91.2%) and sub-cohort II (90.8%, 77.4% and 67.0%, Table 1). Again GIST patients younger than 50 years showed a more favourable outcome which was significantly different (p <0.001; HR = 0.292, 95% CI: 0.140; 0.606, Figure 4A). Regarding gender aspects again female patients particularly with an age <50 years showed better OS (p = 0.002, log-rank test; p = 0.008, cox model; HR = 0.141, 95% CI: 0.033; 0.604, Figure 4B).Figure 4


Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST).

Kramer K, Knippschild U, Mayer B, Bögelspacher K, Spatz H, Henne-Bruns D, Agaimy A, Schwab M, Schmieder M - BMC Cancer (2015)

Age and gender related outcome regarding OS. (A) Kaplan–Meier curves of overall survival (OS) for GIST patients of study cohort I (<50 years at diagnosis) versus study cohort II (≥50 years at diagnosis). (B) Kaplan–Meier curves of overall survival (OS) for female GIST patients of study cohort I (<50 years at diagnosis) versus study cohort II (≥50 years at diagnosis).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4384379&req=5

Fig4: Age and gender related outcome regarding OS. (A) Kaplan–Meier curves of overall survival (OS) for GIST patients of study cohort I (<50 years at diagnosis) versus study cohort II (≥50 years at diagnosis). (B) Kaplan–Meier curves of overall survival (OS) for female GIST patients of study cohort I (<50 years at diagnosis) versus study cohort II (≥50 years at diagnosis).
Mentions: OS-rates were compared after 1-, 3- and 5-year follow up between sub-cohort I (98.5%, 93.2% and 91.2%) and sub-cohort II (90.8%, 77.4% and 67.0%, Table 1). Again GIST patients younger than 50 years showed a more favourable outcome which was significantly different (p <0.001; HR = 0.292, 95% CI: 0.140; 0.606, Figure 4A). Regarding gender aspects again female patients particularly with an age <50 years showed better OS (p = 0.002, log-rank test; p = 0.008, cox model; HR = 0.141, 95% CI: 0.033; 0.604, Figure 4B).Figure 4

Bottom Line: DSS was significantly more favorable in younger female GIST patients compared with elderly females (p = 0.008).Female gender resulted again in better prognosis in younger patients (p = 0.033).Extended studies are warranted to confirm our clinical results and to elucidate underlying pathophysiological mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Department of General and Visceral Surgery, University Hospital Ulm, Albert-Einstein-Allee 23, Ulm, 89081, Germany. klaus.kramer@uniklinik-ulm.de.

ABSTRACT

Background: Risk classification and prediction of prognosis in GIST is still a matter of debate. Data on the impact of age and gender as potential confounding factors are limited. Therefore we comprehensively investigated age and gender as independent risk factors for GIST.

Methods: Two independent patient cohorts (cohort I, n = 87 [<50 years]; cohort II, n = 125 [≥50 years]) were extracted from the multicentre Ulmer GIST registry including a total of 659 GIST patients retrospectively collected in 18 collaborative German oncological centers. Based on demographic and clinicopathological parameters and a median follow-up time of 4.3 years (range 0.56; 21.33) disease-specific-survival (DSS), disease-free-survival (DFS) and overall survival (OS) were calculated.

Results: GIST patients older than fifty years showed significantly worse DSS compared to younger patients (p = 0.021; HR = 0.307, 95% CI [0.113; 0.834]). DSS was significantly more favorable in younger female GIST patients compared with elderly females (p = 0.008). Female gender resulted again in better prognosis in younger patients (p = 0.033).

Conclusions: Patient age (<50 years) and female gender were significantly associated with a more favourable prognosis in GIST. Extended studies are warranted to confirm our clinical results and to elucidate underlying pathophysiological mechanisms.

Show MeSH
Related in: MedlinePlus