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The neutrophil to lymphocyte ratio can discriminate anaplastic thyroid cancer against poorly or well differentiated cancer.

Cho JS, Park MH, Ryu YJ, Yoon JH - Ann Surg Treat Res (2015)

Bottom Line: The proportion of PDTC (0.6% vs. 0.1%) and ATC (0.3% vs. 0.1%) was higher in the high NLR group.The NLR can discriminate between PTC, PDTC, and ATC (P = 0.035, P = 0.002, and P = 0.025, respectively), and the cutoff value was 3.8 between PDTC versus ATC.None of the NLR of PDTC exceeded the cutoff value of 3.8.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Chonnam National University College of Medicine, Gwangju, Korea.

ABSTRACT

Purpose: We evaluated the capability of the neutrophil to lymphocyte ratio (NLR) as a diagnostic tool to discriminate between poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) from well differentiated thyroid cancer (WDTC).

Methods: The NLR of 3,870 patients with benign and malignant thyroid tumors were analyzed. There were 436 benign, 3,364 papillary, 15 medullary, 34 follicular or hurthle type, 14 PDTC, and 7 ATC type neoplasms. Patients were divided into two groups: a high NLR group and a low NLR group.

Results: The NLR of all 3,870 patients was a normal distribution, and the median value was 1.57. Advanced stage cancer, such as T3 or T4 was high (30.4% vs. 26.5%, P = 0.027), and cancer-specific deaths were also high (1.2% vs. 0.4%, P = 0.018) in the high NLR group. The proportion of PDTC (0.6% vs. 0.1%) and ATC (0.3% vs. 0.1%) was higher in the high NLR group. The NLR can discriminate between PTC, PDTC, and ATC (P = 0.035, P = 0.002, and P = 0.025, respectively), and the cutoff value was 3.8 between PDTC versus ATC. None of the NLR of PDTC exceeded the cutoff value of 3.8.

Conclusion: NLR can play a relevant role as a discriminating tool and may be considered as a new diagnostic criterion in discriminating as well as in selecting therapeutic approaches to these aggressive forms of thyroid cancer.

No MeSH data available.


Related in: MedlinePlus

Neutrophil-lymphocyte ratio can discriminate anaplastic thyroid carcinoma from other types of thyroid cancer, especially poorly differentiated thyroid carcinoma (P = 0.025). The cutoff value was 3.8. PTC, papillary thyroid cancer; MTC, medullary thyroid cancer; TFA, thyroid follicular adenoma; TFC, thyroid follicular cancer; HCC, Hurthle cell carcinoma; PDTC, poorly differentiated cancer; ATC, anaplastic cancer.
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Figure 1: Neutrophil-lymphocyte ratio can discriminate anaplastic thyroid carcinoma from other types of thyroid cancer, especially poorly differentiated thyroid carcinoma (P = 0.025). The cutoff value was 3.8. PTC, papillary thyroid cancer; MTC, medullary thyroid cancer; TFA, thyroid follicular adenoma; TFC, thyroid follicular cancer; HCC, Hurthle cell carcinoma; PDTC, poorly differentiated cancer; ATC, anaplastic cancer.

Mentions: There were 14 PDTC, seven ATC, and 3,364 patients with PTC. Of the 21 patients, 85.7% of both tumor types (18/21) had a high NLR equal to or above 1.57. The proportion of PDTC (0.6% [high NLR] vs. 0.1% [low NLR]) and ATC (0.3% [high NLR] vs. 0.1% [low NLR]) was significantly higher in the high NLR group (Table 1). The NLRs of PDTC and ATC were significantly higher and were able to discriminate PDTC from PTC (P = 0.035), ATC from PTC (P = 0.003), and ATC from PDTC (P = 0.025) (Table 2). The cutoff value for discriminating PDTC from ATC was 3.8 (Fig. 1), and none of the NLRs of ATC fell below the cutoff value of 3.8 (Table 3).


The neutrophil to lymphocyte ratio can discriminate anaplastic thyroid cancer against poorly or well differentiated cancer.

Cho JS, Park MH, Ryu YJ, Yoon JH - Ann Surg Treat Res (2015)

Neutrophil-lymphocyte ratio can discriminate anaplastic thyroid carcinoma from other types of thyroid cancer, especially poorly differentiated thyroid carcinoma (P = 0.025). The cutoff value was 3.8. PTC, papillary thyroid cancer; MTC, medullary thyroid cancer; TFA, thyroid follicular adenoma; TFC, thyroid follicular cancer; HCC, Hurthle cell carcinoma; PDTC, poorly differentiated cancer; ATC, anaplastic cancer.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384286&req=5

Figure 1: Neutrophil-lymphocyte ratio can discriminate anaplastic thyroid carcinoma from other types of thyroid cancer, especially poorly differentiated thyroid carcinoma (P = 0.025). The cutoff value was 3.8. PTC, papillary thyroid cancer; MTC, medullary thyroid cancer; TFA, thyroid follicular adenoma; TFC, thyroid follicular cancer; HCC, Hurthle cell carcinoma; PDTC, poorly differentiated cancer; ATC, anaplastic cancer.
Mentions: There were 14 PDTC, seven ATC, and 3,364 patients with PTC. Of the 21 patients, 85.7% of both tumor types (18/21) had a high NLR equal to or above 1.57. The proportion of PDTC (0.6% [high NLR] vs. 0.1% [low NLR]) and ATC (0.3% [high NLR] vs. 0.1% [low NLR]) was significantly higher in the high NLR group (Table 1). The NLRs of PDTC and ATC were significantly higher and were able to discriminate PDTC from PTC (P = 0.035), ATC from PTC (P = 0.003), and ATC from PDTC (P = 0.025) (Table 2). The cutoff value for discriminating PDTC from ATC was 3.8 (Fig. 1), and none of the NLRs of ATC fell below the cutoff value of 3.8 (Table 3).

Bottom Line: The proportion of PDTC (0.6% vs. 0.1%) and ATC (0.3% vs. 0.1%) was higher in the high NLR group.The NLR can discriminate between PTC, PDTC, and ATC (P = 0.035, P = 0.002, and P = 0.025, respectively), and the cutoff value was 3.8 between PDTC versus ATC.None of the NLR of PDTC exceeded the cutoff value of 3.8.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Chonnam National University College of Medicine, Gwangju, Korea.

ABSTRACT

Purpose: We evaluated the capability of the neutrophil to lymphocyte ratio (NLR) as a diagnostic tool to discriminate between poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) from well differentiated thyroid cancer (WDTC).

Methods: The NLR of 3,870 patients with benign and malignant thyroid tumors were analyzed. There were 436 benign, 3,364 papillary, 15 medullary, 34 follicular or hurthle type, 14 PDTC, and 7 ATC type neoplasms. Patients were divided into two groups: a high NLR group and a low NLR group.

Results: The NLR of all 3,870 patients was a normal distribution, and the median value was 1.57. Advanced stage cancer, such as T3 or T4 was high (30.4% vs. 26.5%, P = 0.027), and cancer-specific deaths were also high (1.2% vs. 0.4%, P = 0.018) in the high NLR group. The proportion of PDTC (0.6% vs. 0.1%) and ATC (0.3% vs. 0.1%) was higher in the high NLR group. The NLR can discriminate between PTC, PDTC, and ATC (P = 0.035, P = 0.002, and P = 0.025, respectively), and the cutoff value was 3.8 between PDTC versus ATC. None of the NLR of PDTC exceeded the cutoff value of 3.8.

Conclusion: NLR can play a relevant role as a discriminating tool and may be considered as a new diagnostic criterion in discriminating as well as in selecting therapeutic approaches to these aggressive forms of thyroid cancer.

No MeSH data available.


Related in: MedlinePlus