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Ki-67 and p53 expression as a predictive marker for early postoperative recurrence in pancreatic head cancer.

Kim H, Park CY, Lee JH, Kim JC, Cho CK, Kim HJ - Ann Surg Treat Res (2015)

Bottom Line: Clinical and histopathological characteristics were analyzed, relative to p53 expression.Importantly, Ki-67 was the independent predictive factor for postoperative recurrence within 1 year in both univariable and multivariable analyses (odds ratio, 27.219; 95% confidence interval, 1.403-528.135; P = 0.029).Especially, Ki-67 was the independent predictive factor for postoperative recurrence within 1 year.

View Article: PubMed Central - PubMed

Affiliation: Department of Trauma Surgery, Pusan National University Hospital, Busan, Korea.

ABSTRACT

Purpose: This study aimed to evaluate the clinical significance of Ki-67 and p53 expressions in patients with pancreatic head cancer.

Methods: Between May 2008 and April 2013, immunohistochemical staining for Ki-67 and p53 was performed in 34 patients with pancreatic head cancer (ductal adenocarcinoma). All 34 patients underwent pancreaticoduodenectomy at Chonnam National University Hwasun Hospital, Hwasun, Korea. Clinical and histopathological characteristics were analyzed, relative to p53 expression.

Results: Thirty (88.2%) and twenty-one (61.7%) of the 34 pancreatic head cancers exhibited positive expression of Ki-67 and p53, respectively. Patients expressing Ki-67 and p53 experienced more frequent tumor recurrences within 1 year after surgical resection (P = 0.003 and P = 0.030, respectively). However, no correlation was detected between Ki-67 and p53 expression. Ki-67 expression was correlated with pathological grade, lymph node metasatsis, and clinical stage (P < 0.05). Importantly, Ki-67 was the independent predictive factor for postoperative recurrence within 1 year in both univariable and multivariable analyses (odds ratio, 27.219; 95% confidence interval, 1.403-528.135; P = 0.029).

Conclusion: The expression of Ki-67 and p53 are significantly related to early postoperative recurrence within 1 year after surgical resection in pancreatic head cancer. Especially, Ki-67 was the independent predictive factor for postoperative recurrence within 1 year. Therefore, immunohistochemical staining for Ki-67 and p53 may be applied as a predictive marker for early postoperative recurrence in pancreatic head cancer.

No MeSH data available.


Related in: MedlinePlus

Cumulative recurrence rates after surgical resection according to the degree of Ki-67 (A) and p53 expression (B) in pancreatic head cancer tissue. Overall recurrence-free survival rates were not different between patients with Ki-67 and p53 expression (P = 0.055 and P = 0.053, respectively). However, the recurrence-rate within 1 year after surgical resection was significantly lower in pancreatic head cancer patients expressing Ki-67 (P = 0.003) and p53 (42.8% vs. 84.6%, P = 0.030).
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Figure 2: Cumulative recurrence rates after surgical resection according to the degree of Ki-67 (A) and p53 expression (B) in pancreatic head cancer tissue. Overall recurrence-free survival rates were not different between patients with Ki-67 and p53 expression (P = 0.055 and P = 0.053, respectively). However, the recurrence-rate within 1 year after surgical resection was significantly lower in pancreatic head cancer patients expressing Ki-67 (P = 0.003) and p53 (42.8% vs. 84.6%, P = 0.030).

Mentions: During the follow-up with a mean period of 19.7 ± 14.4 months, the overall recurrence-free survival rates were not different between patients with Ki-67 and p53 expression (P = 0.055 and P = 0.053, respectively) (Fig. 2). However, differences in the recurrence rates were significantly evident within 1 year after surgical resection. The recurrence rates in pancreatic head cancer patients with Ki-67 expression were 0% (nonexpression group), 46.7% (weak), 81.8% (moderate), and 100% (strong) at 1 year (P = 0.001). The recurrence rates with and without p53 expression were 84.6% and 42.8% at 1 year (P = 0.030).


Ki-67 and p53 expression as a predictive marker for early postoperative recurrence in pancreatic head cancer.

Kim H, Park CY, Lee JH, Kim JC, Cho CK, Kim HJ - Ann Surg Treat Res (2015)

Cumulative recurrence rates after surgical resection according to the degree of Ki-67 (A) and p53 expression (B) in pancreatic head cancer tissue. Overall recurrence-free survival rates were not different between patients with Ki-67 and p53 expression (P = 0.055 and P = 0.053, respectively). However, the recurrence-rate within 1 year after surgical resection was significantly lower in pancreatic head cancer patients expressing Ki-67 (P = 0.003) and p53 (42.8% vs. 84.6%, P = 0.030).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384285&req=5

Figure 2: Cumulative recurrence rates after surgical resection according to the degree of Ki-67 (A) and p53 expression (B) in pancreatic head cancer tissue. Overall recurrence-free survival rates were not different between patients with Ki-67 and p53 expression (P = 0.055 and P = 0.053, respectively). However, the recurrence-rate within 1 year after surgical resection was significantly lower in pancreatic head cancer patients expressing Ki-67 (P = 0.003) and p53 (42.8% vs. 84.6%, P = 0.030).
Mentions: During the follow-up with a mean period of 19.7 ± 14.4 months, the overall recurrence-free survival rates were not different between patients with Ki-67 and p53 expression (P = 0.055 and P = 0.053, respectively) (Fig. 2). However, differences in the recurrence rates were significantly evident within 1 year after surgical resection. The recurrence rates in pancreatic head cancer patients with Ki-67 expression were 0% (nonexpression group), 46.7% (weak), 81.8% (moderate), and 100% (strong) at 1 year (P = 0.001). The recurrence rates with and without p53 expression were 84.6% and 42.8% at 1 year (P = 0.030).

Bottom Line: Clinical and histopathological characteristics were analyzed, relative to p53 expression.Importantly, Ki-67 was the independent predictive factor for postoperative recurrence within 1 year in both univariable and multivariable analyses (odds ratio, 27.219; 95% confidence interval, 1.403-528.135; P = 0.029).Especially, Ki-67 was the independent predictive factor for postoperative recurrence within 1 year.

View Article: PubMed Central - PubMed

Affiliation: Department of Trauma Surgery, Pusan National University Hospital, Busan, Korea.

ABSTRACT

Purpose: This study aimed to evaluate the clinical significance of Ki-67 and p53 expressions in patients with pancreatic head cancer.

Methods: Between May 2008 and April 2013, immunohistochemical staining for Ki-67 and p53 was performed in 34 patients with pancreatic head cancer (ductal adenocarcinoma). All 34 patients underwent pancreaticoduodenectomy at Chonnam National University Hwasun Hospital, Hwasun, Korea. Clinical and histopathological characteristics were analyzed, relative to p53 expression.

Results: Thirty (88.2%) and twenty-one (61.7%) of the 34 pancreatic head cancers exhibited positive expression of Ki-67 and p53, respectively. Patients expressing Ki-67 and p53 experienced more frequent tumor recurrences within 1 year after surgical resection (P = 0.003 and P = 0.030, respectively). However, no correlation was detected between Ki-67 and p53 expression. Ki-67 expression was correlated with pathological grade, lymph node metasatsis, and clinical stage (P < 0.05). Importantly, Ki-67 was the independent predictive factor for postoperative recurrence within 1 year in both univariable and multivariable analyses (odds ratio, 27.219; 95% confidence interval, 1.403-528.135; P = 0.029).

Conclusion: The expression of Ki-67 and p53 are significantly related to early postoperative recurrence within 1 year after surgical resection in pancreatic head cancer. Especially, Ki-67 was the independent predictive factor for postoperative recurrence within 1 year. Therefore, immunohistochemical staining for Ki-67 and p53 may be applied as a predictive marker for early postoperative recurrence in pancreatic head cancer.

No MeSH data available.


Related in: MedlinePlus