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Exposure to household air pollution from wood combustion and association with respiratory symptoms and lung function in nonsmoking women: results from the RESPIRE trial, Guatemala.

Pope D, Diaz E, Smith-Sivertsen T, Lie RT, Bakke P, Balmes JR, Smith KR, Bruce NG - Environ. Health Perspect. (2014)

Bottom Line: Respiratory symptoms (cough, phlegm, wheeze, or chest tightness) during the previous 6 months were positively associated with breath CO measured at the same time of symptom reporting and with average personal CO concentrations during the follow-up period.CO in exhaled breath at the same time as spirometry was associated with lower lung function [average reduction in FEV1 (forced expiratory volume in 1 sec) for a 10% increase in CO was 3.33 mL (95% CI: -0.86, -5.81)].Our results provide further support for the effects of HAP exposures on airway inflammation.

View Article: PubMed Central - PubMed

Affiliation: Division of Public Health and Policy, University of Liverpool, Liverpool, United Kingdom.

ABSTRACT

Background: With 40% of the world's population relying on solid fuel, household air pollution (HAP) represents a major preventable risk factor for COPD (chronic obstructive pulmonary disease). Meta-analyses have confirmed this relationship; however, constituent studies are observational, with virtually none measuring exposure directly.

Objectives: We estimated associations between HAP exposure and respiratory symptoms and lung function in young, nonsmoking women in rural Guatemala, using measured carbon monoxide (CO) concentrations in exhaled breath and personal air to assess exposure.

Methods: The Randomized Exposure Study of Pollution Indoors and Respiratory Effects (RESPIRE) Guatemala study was a trial comparing respiratory outcomes among 504 women using improved chimney stoves versus traditional cookstoves. The present analysis included 456 women with data from postintervention surveys including interviews at 6, 12, and 18 months (respiratory symptoms) and spirometry and CO (ppm) in exhaled breath measurements. Personal CO was measured using passive diffusion tubes at variable times during the study. Associations between CO concentrations and respiratory health were estimated using random intercept regression models.

Results: Respiratory symptoms (cough, phlegm, wheeze, or chest tightness) during the previous 6 months were positively associated with breath CO measured at the same time of symptom reporting and with average personal CO concentrations during the follow-up period. CO in exhaled breath at the same time as spirometry was associated with lower lung function [average reduction in FEV1 (forced expiratory volume in 1 sec) for a 10% increase in CO was 3.33 mL (95% CI: -0.86, -5.81)]. Lung function measures were not significantly associated with average postintervention personal CO concentrations.

Conclusions: Our results provide further support for the effects of HAP exposures on airway inflammation. Further longitudinal research modeling continuous exposure to particulate matter against lung function will help us understand more fully the impact of HAP on COPD.

No MeSH data available.


Related in: MedlinePlus

Timing of assessment of personal exposure using CO tubes and of symptoms, lung function, and CO breath, in relation to the installation of the chimney stove, for recruitment groups A and B. Abbreviations: B, baseline; PI, postintervention; Q1–Q4, yearly quarters (3-month intervals). Number of CO tubes is listed (1–5).
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f1: Timing of assessment of personal exposure using CO tubes and of symptoms, lung function, and CO breath, in relation to the installation of the chimney stove, for recruitment groups A and B. Abbreviations: B, baseline; PI, postintervention; Q1–Q4, yearly quarters (3-month intervals). Number of CO tubes is listed (1–5).

Mentions: The study was carried out over 2 years (October 2002 through December 2004). Women were surveyed at baseline, before randomization, and every 6 months until 12 months (group A) and 18 months (group B) after randomization to intervention and control groups (Figure 1). Questionnaires were administered at each survey by a trained bilingual interviewer. Information included age, height, weight, pregnancy status, smoking, respiratory symptoms, and days since the temazcal was last used. Household information included building construction/layout, number of children, others smoking, and number of consumer goods possessed (radio, television, refrigerator, bicycle, motorcycle, and car) combined into an asset index. Lung function and breath CO were measured at the woman’s home after the interview, and personal 48-hr CO exposure (diffusion tubes) was assessed at different times (Figure 1).


Exposure to household air pollution from wood combustion and association with respiratory symptoms and lung function in nonsmoking women: results from the RESPIRE trial, Guatemala.

Pope D, Diaz E, Smith-Sivertsen T, Lie RT, Bakke P, Balmes JR, Smith KR, Bruce NG - Environ. Health Perspect. (2014)

Timing of assessment of personal exposure using CO tubes and of symptoms, lung function, and CO breath, in relation to the installation of the chimney stove, for recruitment groups A and B. Abbreviations: B, baseline; PI, postintervention; Q1–Q4, yearly quarters (3-month intervals). Number of CO tubes is listed (1–5).
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384202&req=5

f1: Timing of assessment of personal exposure using CO tubes and of symptoms, lung function, and CO breath, in relation to the installation of the chimney stove, for recruitment groups A and B. Abbreviations: B, baseline; PI, postintervention; Q1–Q4, yearly quarters (3-month intervals). Number of CO tubes is listed (1–5).
Mentions: The study was carried out over 2 years (October 2002 through December 2004). Women were surveyed at baseline, before randomization, and every 6 months until 12 months (group A) and 18 months (group B) after randomization to intervention and control groups (Figure 1). Questionnaires were administered at each survey by a trained bilingual interviewer. Information included age, height, weight, pregnancy status, smoking, respiratory symptoms, and days since the temazcal was last used. Household information included building construction/layout, number of children, others smoking, and number of consumer goods possessed (radio, television, refrigerator, bicycle, motorcycle, and car) combined into an asset index. Lung function and breath CO were measured at the woman’s home after the interview, and personal 48-hr CO exposure (diffusion tubes) was assessed at different times (Figure 1).

Bottom Line: Respiratory symptoms (cough, phlegm, wheeze, or chest tightness) during the previous 6 months were positively associated with breath CO measured at the same time of symptom reporting and with average personal CO concentrations during the follow-up period.CO in exhaled breath at the same time as spirometry was associated with lower lung function [average reduction in FEV1 (forced expiratory volume in 1 sec) for a 10% increase in CO was 3.33 mL (95% CI: -0.86, -5.81)].Our results provide further support for the effects of HAP exposures on airway inflammation.

View Article: PubMed Central - PubMed

Affiliation: Division of Public Health and Policy, University of Liverpool, Liverpool, United Kingdom.

ABSTRACT

Background: With 40% of the world's population relying on solid fuel, household air pollution (HAP) represents a major preventable risk factor for COPD (chronic obstructive pulmonary disease). Meta-analyses have confirmed this relationship; however, constituent studies are observational, with virtually none measuring exposure directly.

Objectives: We estimated associations between HAP exposure and respiratory symptoms and lung function in young, nonsmoking women in rural Guatemala, using measured carbon monoxide (CO) concentrations in exhaled breath and personal air to assess exposure.

Methods: The Randomized Exposure Study of Pollution Indoors and Respiratory Effects (RESPIRE) Guatemala study was a trial comparing respiratory outcomes among 504 women using improved chimney stoves versus traditional cookstoves. The present analysis included 456 women with data from postintervention surveys including interviews at 6, 12, and 18 months (respiratory symptoms) and spirometry and CO (ppm) in exhaled breath measurements. Personal CO was measured using passive diffusion tubes at variable times during the study. Associations between CO concentrations and respiratory health were estimated using random intercept regression models.

Results: Respiratory symptoms (cough, phlegm, wheeze, or chest tightness) during the previous 6 months were positively associated with breath CO measured at the same time of symptom reporting and with average personal CO concentrations during the follow-up period. CO in exhaled breath at the same time as spirometry was associated with lower lung function [average reduction in FEV1 (forced expiratory volume in 1 sec) for a 10% increase in CO was 3.33 mL (95% CI: -0.86, -5.81)]. Lung function measures were not significantly associated with average postintervention personal CO concentrations.

Conclusions: Our results provide further support for the effects of HAP exposures on airway inflammation. Further longitudinal research modeling continuous exposure to particulate matter against lung function will help us understand more fully the impact of HAP on COPD.

No MeSH data available.


Related in: MedlinePlus