Limits...
Prenatal air pollution exposure and newborn blood pressure.

van Rossem L, Rifas-Shiman SL, Melly SJ, Kloog I, Luttmann-Gibson H, Zanobetti A, Coull BA, Schwartz JD, Mittleman MA, Oken E, Gillman MW, Koutrakis P, Gold DR - Environ. Health Perspect. (2015)

Bottom Line: Estimates represent differences in SBP associated with an interquartile range (IQR) increase in each pollutant.In contrast, O3 was negatively associated with SBP (e.g., -2.3 mmHg; 95% CI: -4.4, -0.2 for a 13.5-ppb increase during the 90 days before birth).Longitudinal follow-up will enable us to assess the implications of these findings for health during later childhood and adulthood.

View Article: PubMed Central - PubMed

Affiliation: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.

ABSTRACT

Background: Air pollution exposure has been associated with increased blood pressure in adults.

Objective: We examined associations of antenatal exposure to ambient air pollution with newborn systolic blood pressure (SBP).

Methods: We studied 1,131 mother-infant pairs in a Boston, Massachusetts, area pre-birth cohort. We calculated average exposures by trimester and during the 2 to 90 days before birth for temporally resolved fine particulate matter (≤ 2.5 μm; PM2.5), black carbon (BC), nitrogen oxides, nitrogen dioxide, ozone (O3), and carbon monoxide measured at stationary monitoring sites, and for spatiotemporally resolved estimates of PM2.5 and BC at the residence level. We measured SBP at a mean age of 30 ± 18 hr with an automated device. We used mixed-effects models to examine associations between air pollutant exposures and SBP, taking into account measurement circumstances; child's birth weight; mother's age, race/ethnicity, socioeconomic position, and third-trimester BP; and time trend. Estimates represent differences in SBP associated with an interquartile range (IQR) increase in each pollutant.

Results: Higher mean PM2.5 and BC exposures during the third trimester were associated with higher SBP (e.g., 1.0 mmHg; 95% CI: 0.1, 1.8 for a 0.32-μg/m3 increase in mean 90-day residential BC). In contrast, O3 was negatively associated with SBP (e.g., -2.3 mmHg; 95% CI: -4.4, -0.2 for a 13.5-ppb increase during the 90 days before birth).

Conclusions: Exposures to PM2.5 and BC in late pregnancy were positively associated with newborn SBP, whereas O3 was negatively associated with SBP. Longitudinal follow-up will enable us to assess the implications of these findings for health during later childhood and adulthood.

No MeSH data available.


Related in: MedlinePlus

Association of spatiotemporally (ST) resolved PM2.5 exposure, temporally (T) resolved PM2.5, spatiotemporally resolved BC, and temporally resolved BC during different time windows before birth (“moving averages”) with BP in newborns. Estimates represent mean difference in SBP (95% CI) for an IQR in exposure and are adjusted for neighborhood median income; mother’s age, third-trimester BP, educational level, and race/ethnicity; child birth weight; infant’s age at BP measurement, BP measurement conditions; and time trend.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4384198&req=5

f1: Association of spatiotemporally (ST) resolved PM2.5 exposure, temporally (T) resolved PM2.5, spatiotemporally resolved BC, and temporally resolved BC during different time windows before birth (“moving averages”) with BP in newborns. Estimates represent mean difference in SBP (95% CI) for an IQR in exposure and are adjusted for neighborhood median income; mother’s age, third-trimester BP, educational level, and race/ethnicity; child birth weight; infant’s age at BP measurement, BP measurement conditions; and time trend.

Mentions: For BC and PM2.5, cumulative 2- to 90-day exposure was positively associated with SBP, and suggested possible effects of short-term exposures, as well as effects of more long-term exposures (Figure 1). Associations for temporally resolved and spatiotemporally resolved BC and PM2.5 were similar, although associations with spatiotemporally resolved PM2.5 seemed to decrease for longer-term exposures. For the gases, the predominant associations were related to long-term 30- to 90-day averages (Figure 2), particularly for O3 and NOx, where O3 was negatively associated with SBP and NOx was positively associated with SBP.


Prenatal air pollution exposure and newborn blood pressure.

van Rossem L, Rifas-Shiman SL, Melly SJ, Kloog I, Luttmann-Gibson H, Zanobetti A, Coull BA, Schwartz JD, Mittleman MA, Oken E, Gillman MW, Koutrakis P, Gold DR - Environ. Health Perspect. (2015)

Association of spatiotemporally (ST) resolved PM2.5 exposure, temporally (T) resolved PM2.5, spatiotemporally resolved BC, and temporally resolved BC during different time windows before birth (“moving averages”) with BP in newborns. Estimates represent mean difference in SBP (95% CI) for an IQR in exposure and are adjusted for neighborhood median income; mother’s age, third-trimester BP, educational level, and race/ethnicity; child birth weight; infant’s age at BP measurement, BP measurement conditions; and time trend.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384198&req=5

f1: Association of spatiotemporally (ST) resolved PM2.5 exposure, temporally (T) resolved PM2.5, spatiotemporally resolved BC, and temporally resolved BC during different time windows before birth (“moving averages”) with BP in newborns. Estimates represent mean difference in SBP (95% CI) for an IQR in exposure and are adjusted for neighborhood median income; mother’s age, third-trimester BP, educational level, and race/ethnicity; child birth weight; infant’s age at BP measurement, BP measurement conditions; and time trend.
Mentions: For BC and PM2.5, cumulative 2- to 90-day exposure was positively associated with SBP, and suggested possible effects of short-term exposures, as well as effects of more long-term exposures (Figure 1). Associations for temporally resolved and spatiotemporally resolved BC and PM2.5 were similar, although associations with spatiotemporally resolved PM2.5 seemed to decrease for longer-term exposures. For the gases, the predominant associations were related to long-term 30- to 90-day averages (Figure 2), particularly for O3 and NOx, where O3 was negatively associated with SBP and NOx was positively associated with SBP.

Bottom Line: Estimates represent differences in SBP associated with an interquartile range (IQR) increase in each pollutant.In contrast, O3 was negatively associated with SBP (e.g., -2.3 mmHg; 95% CI: -4.4, -0.2 for a 13.5-ppb increase during the 90 days before birth).Longitudinal follow-up will enable us to assess the implications of these findings for health during later childhood and adulthood.

View Article: PubMed Central - PubMed

Affiliation: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.

ABSTRACT

Background: Air pollution exposure has been associated with increased blood pressure in adults.

Objective: We examined associations of antenatal exposure to ambient air pollution with newborn systolic blood pressure (SBP).

Methods: We studied 1,131 mother-infant pairs in a Boston, Massachusetts, area pre-birth cohort. We calculated average exposures by trimester and during the 2 to 90 days before birth for temporally resolved fine particulate matter (≤ 2.5 μm; PM2.5), black carbon (BC), nitrogen oxides, nitrogen dioxide, ozone (O3), and carbon monoxide measured at stationary monitoring sites, and for spatiotemporally resolved estimates of PM2.5 and BC at the residence level. We measured SBP at a mean age of 30 ± 18 hr with an automated device. We used mixed-effects models to examine associations between air pollutant exposures and SBP, taking into account measurement circumstances; child's birth weight; mother's age, race/ethnicity, socioeconomic position, and third-trimester BP; and time trend. Estimates represent differences in SBP associated with an interquartile range (IQR) increase in each pollutant.

Results: Higher mean PM2.5 and BC exposures during the third trimester were associated with higher SBP (e.g., 1.0 mmHg; 95% CI: 0.1, 1.8 for a 0.32-μg/m3 increase in mean 90-day residential BC). In contrast, O3 was negatively associated with SBP (e.g., -2.3 mmHg; 95% CI: -4.4, -0.2 for a 13.5-ppb increase during the 90 days before birth).

Conclusions: Exposures to PM2.5 and BC in late pregnancy were positively associated with newborn SBP, whereas O3 was negatively associated with SBP. Longitudinal follow-up will enable us to assess the implications of these findings for health during later childhood and adulthood.

No MeSH data available.


Related in: MedlinePlus