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XRCC1 and XPD genetic polymorphisms and susceptibility to age-related cataract: a meta-analysis.

Chi XX, Liu YY, Shi SN, Cong Z, Liang YQ, Zhang HJ - Mol. Vis. (2015)

Bottom Line: Medline (1966-2013), the Cochrane Library Database (Issue 12, 2013), EMBASE (1980-2013), CINAHL (1982-2013), Web of Science (1945-2013) and the Chinese Biomedical Database (CBM; 1982-2013) were searched without language restrictions.Crude odds ratios (ORs) and their corresponding 95% confidence intervals (95% CI) were calculated.Six independent case-control studies were included in the meta-analysis.

View Article: PubMed Central - PubMed

Affiliation: College nursing, Liaoning Medical University, Jinzhou, P.R. China.

ABSTRACT

Objective: This meta-analysis aimed to determine the relationships between XRCC1 Arg399Gln (rs25487 G>A) and XPD Lys751Gln (rs1052559 A>C) polymorphisms and susceptibility to age-related cataract.

Methods: Medline (1966-2013), the Cochrane Library Database (Issue 12, 2013), EMBASE (1980-2013), CINAHL (1982-2013), Web of Science (1945-2013) and the Chinese Biomedical Database (CBM; 1982-2013) were searched without language restrictions. Various combinations of the keywords and MeSH terms were used to screen for potentially relevant studies, specifically "genetic polymorphisms" or "SNPs" or "variation" or "single nucleotide polymorphism" or "polymorphism" or "mutation" or "variant"; "X-ray repair cross complementing protein 1" or "Xeroderma Pigmentosum Group D Protein" or "X-ray repair cross complementing protein 1" or "Xeroderma Pigmentosum Group D Protein" or "XPD" or "Xeroderma Pigmentosum Complementation Group D Protein" or "ERCC2" or "XRCC1" or "XRCC1 DNA repair protein"; and "Cataract" or " Membranous Cataract" or " Pseudoaphakia." Meta-analyses were conducted using Stata 12.0 software. Crude odds ratios (ORs) and their corresponding 95% confidence intervals (95% CI) were calculated.

Results: Six independent case-control studies were included in the meta-analysis. Our results indicated that the association between the genetic polymorphisms of XRCC1 Arg399Gln G>A and XPD Lys751Gln A>C and increased susceptibility to age-related cataracts was statistically significant (XRCC1 Arg399Gln: OR=1.30, 95% CI=1.17-1.44, p<0.001; XPD Lys751Gln: OR=1.25, 95% CI=1.12-1.40, p<0.001, respectively). Ethnicity-stratified analysis indicated that the XRCC1 Arg399Gln G>A polymorphism was correlated with the development and progression of age-related cataract in China, India, and Turkey in the allele model and the dominant model. For the XPD Lys751Gln A>C variant, the association with the pathogenesis of age-related cataract in China and Turkey in the allele model and the dominant model was investigated.

Conclusions: The association of XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms with age-related cataract susceptibility observed in our meta-analyses supports the view that XRCC1 and XPD may play important roles in susceptibility to age-related cataract.

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Related in: MedlinePlus

Subgroup analyses for the relationships of XRCC1 and XPD SNPs with susceptibility to age-related cataract under the allele and dominant models.
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f4: Subgroup analyses for the relationships of XRCC1 and XPD SNPs with susceptibility to age-related cataract under the allele and dominant models.

Mentions: We also conducted subgroup analysis to investigate the potential influence of factors on individuals’ risk of age-related cataracts. In the subgroup analysis based on country, we found that the XRCC1 Arg399Gln G>A polymorphisms were correlated with development and susceptibility to age-related cataracts among residents of China, India, and Turkey in the allele model (all p<0.05) and among China and India in the dominant model (all p<0.05). For the XPD Lys751Gln A>C polymorphism, the association with the pathogenesis of age-related cataracts among Turkey in the allele model (OR=1.48, 95% CI=1.23–1.78, p=0.001) and among China and Turkey in the dominant model (China: OR=33.37, 95% CI=20.93–53.21, p<0.001; Turkey: OR=5.70, 95% CI=3.43–9.47, p<0.001) was investigated (Figure 4). Furthermore, in the disease subgroup analysis, there were significant connections between the XRCC1 Arg399Gln polymorphism and the risk of mixed and nuclear cataracts in Turkey (mixed: allele model: OR=1.36, 95% CI=1.13–1.64, p=0.001; dominant model: OR=1.44, 95% CI=1.16–1.79, p=0.001; nuclear: allele model: OR=1.35, 95% CI=1.06–1.69, p=0.008; dominant model: OR=1.45, 95% CI=1.07–1.97, p=0.016), but no such relation was observed in the cortical and posterior subcapsular cataract groups (cortical: allele model: OR=1.23, 95% CI=0.99–1.54, p=0.064; dominant model: OR=1.31, 95% CI=0.92–1.85, p=0.134; posterior subcapsular: allele model: OR=1.14, 95% CI=0.88–1.48, p=0.313; dominant model: OR=1.21, 95% CI=0.86–1.71, p=0.282). We also found that polymorphisms of XPD Lys751Gln were related to the risk of mixed cataracts in the allele model (OR=1.20, 95% CI=1.03–1.39, p=0.016) and mixed cataract, cortical, nuclear, and posterior subcapsular cataract in the dominant model (mixed cataract: OR=26.26, 95% CI=9.42–73.22, p<0.001; cortical: OR=26.14, 95% CI=10.42–65.58, p<0.001; nuclear: OR=8.17, 95% CI=2.05–32.49, p=0.003; posterior subcapsular: OR=7.58, 95% CI=1.08–53.35, p=0.042; Figure 4).


XRCC1 and XPD genetic polymorphisms and susceptibility to age-related cataract: a meta-analysis.

Chi XX, Liu YY, Shi SN, Cong Z, Liang YQ, Zhang HJ - Mol. Vis. (2015)

Subgroup analyses for the relationships of XRCC1 and XPD SNPs with susceptibility to age-related cataract under the allele and dominant models.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384174&req=5

f4: Subgroup analyses for the relationships of XRCC1 and XPD SNPs with susceptibility to age-related cataract under the allele and dominant models.
Mentions: We also conducted subgroup analysis to investigate the potential influence of factors on individuals’ risk of age-related cataracts. In the subgroup analysis based on country, we found that the XRCC1 Arg399Gln G>A polymorphisms were correlated with development and susceptibility to age-related cataracts among residents of China, India, and Turkey in the allele model (all p<0.05) and among China and India in the dominant model (all p<0.05). For the XPD Lys751Gln A>C polymorphism, the association with the pathogenesis of age-related cataracts among Turkey in the allele model (OR=1.48, 95% CI=1.23–1.78, p=0.001) and among China and Turkey in the dominant model (China: OR=33.37, 95% CI=20.93–53.21, p<0.001; Turkey: OR=5.70, 95% CI=3.43–9.47, p<0.001) was investigated (Figure 4). Furthermore, in the disease subgroup analysis, there were significant connections between the XRCC1 Arg399Gln polymorphism and the risk of mixed and nuclear cataracts in Turkey (mixed: allele model: OR=1.36, 95% CI=1.13–1.64, p=0.001; dominant model: OR=1.44, 95% CI=1.16–1.79, p=0.001; nuclear: allele model: OR=1.35, 95% CI=1.06–1.69, p=0.008; dominant model: OR=1.45, 95% CI=1.07–1.97, p=0.016), but no such relation was observed in the cortical and posterior subcapsular cataract groups (cortical: allele model: OR=1.23, 95% CI=0.99–1.54, p=0.064; dominant model: OR=1.31, 95% CI=0.92–1.85, p=0.134; posterior subcapsular: allele model: OR=1.14, 95% CI=0.88–1.48, p=0.313; dominant model: OR=1.21, 95% CI=0.86–1.71, p=0.282). We also found that polymorphisms of XPD Lys751Gln were related to the risk of mixed cataracts in the allele model (OR=1.20, 95% CI=1.03–1.39, p=0.016) and mixed cataract, cortical, nuclear, and posterior subcapsular cataract in the dominant model (mixed cataract: OR=26.26, 95% CI=9.42–73.22, p<0.001; cortical: OR=26.14, 95% CI=10.42–65.58, p<0.001; nuclear: OR=8.17, 95% CI=2.05–32.49, p=0.003; posterior subcapsular: OR=7.58, 95% CI=1.08–53.35, p=0.042; Figure 4).

Bottom Line: Medline (1966-2013), the Cochrane Library Database (Issue 12, 2013), EMBASE (1980-2013), CINAHL (1982-2013), Web of Science (1945-2013) and the Chinese Biomedical Database (CBM; 1982-2013) were searched without language restrictions.Crude odds ratios (ORs) and their corresponding 95% confidence intervals (95% CI) were calculated.Six independent case-control studies were included in the meta-analysis.

View Article: PubMed Central - PubMed

Affiliation: College nursing, Liaoning Medical University, Jinzhou, P.R. China.

ABSTRACT

Objective: This meta-analysis aimed to determine the relationships between XRCC1 Arg399Gln (rs25487 G>A) and XPD Lys751Gln (rs1052559 A>C) polymorphisms and susceptibility to age-related cataract.

Methods: Medline (1966-2013), the Cochrane Library Database (Issue 12, 2013), EMBASE (1980-2013), CINAHL (1982-2013), Web of Science (1945-2013) and the Chinese Biomedical Database (CBM; 1982-2013) were searched without language restrictions. Various combinations of the keywords and MeSH terms were used to screen for potentially relevant studies, specifically "genetic polymorphisms" or "SNPs" or "variation" or "single nucleotide polymorphism" or "polymorphism" or "mutation" or "variant"; "X-ray repair cross complementing protein 1" or "Xeroderma Pigmentosum Group D Protein" or "X-ray repair cross complementing protein 1" or "Xeroderma Pigmentosum Group D Protein" or "XPD" or "Xeroderma Pigmentosum Complementation Group D Protein" or "ERCC2" or "XRCC1" or "XRCC1 DNA repair protein"; and "Cataract" or " Membranous Cataract" or " Pseudoaphakia." Meta-analyses were conducted using Stata 12.0 software. Crude odds ratios (ORs) and their corresponding 95% confidence intervals (95% CI) were calculated.

Results: Six independent case-control studies were included in the meta-analysis. Our results indicated that the association between the genetic polymorphisms of XRCC1 Arg399Gln G>A and XPD Lys751Gln A>C and increased susceptibility to age-related cataracts was statistically significant (XRCC1 Arg399Gln: OR=1.30, 95% CI=1.17-1.44, p<0.001; XPD Lys751Gln: OR=1.25, 95% CI=1.12-1.40, p<0.001, respectively). Ethnicity-stratified analysis indicated that the XRCC1 Arg399Gln G>A polymorphism was correlated with the development and progression of age-related cataract in China, India, and Turkey in the allele model and the dominant model. For the XPD Lys751Gln A>C variant, the association with the pathogenesis of age-related cataract in China and Turkey in the allele model and the dominant model was investigated.

Conclusions: The association of XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms with age-related cataract susceptibility observed in our meta-analyses supports the view that XRCC1 and XPD may play important roles in susceptibility to age-related cataract.

Show MeSH
Related in: MedlinePlus