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Immunoglobulin isotypes in Atlantic salmon, Salmo salar.

Hordvik I - Biomolecules (2015)

Bottom Line: The IgM-B sub-variant has a characteristic extra cysteine near the C-terminal part of the heavy chain and exhibits a higher degree of polymer disulfide cross-linking compared to IgM-A.The concentration of IgT in serum is 100 to 1000 times lower than IgM.Secreted forms of IgD have been detected in rainbow trout, but not yet in Atlantic salmon.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology (BIO), High Technology Center, University of Bergen, Bergen N-5020, Norway. ivar.hordvik@bio.uib.no.

ABSTRACT
There are three major immunoglobulin (Ig) isotypes in salmonid fish: IgM, IgD and IgT, defined by the heavy chains μ, δ and τ, respectively. As a result of whole genome duplication in the ancestor of the salmonid fish family, Atlantic salmon (Salmo salar) possess two highly similar Ig heavy chain gene complexes (A and B), comprising two μ genes, two δ genes, three intact τ genes and five τ pseudogenes. The μA and μB genes correspond to two distinct sub-populations of serum IgM. The IgM-B sub-variant has a characteristic extra cysteine near the C-terminal part of the heavy chain and exhibits a higher degree of polymer disulfide cross-linking compared to IgM-A. The IgM-B:IgM-A ratio in serum is typically 60:40, but skewed ratios are also observed. The IgT isotype appears to be specialized to mucosal immune responses in salmonid fish. The concentration of IgT in serum is 100 to 1000 times lower than IgM. Secreted forms of IgD have been detected in rainbow trout, but not yet in Atlantic salmon.

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Comparison of serum immunoglobulin (IgM) concentrations in different teleosts [40] compared to human (IgM + IgG + IgA). IgM is indicated with dark blue, IgG with light blue and IgA with red.
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biomolecules-05-00166-f003: Comparison of serum immunoglobulin (IgM) concentrations in different teleosts [40] compared to human (IgM + IgG + IgA). IgM is indicated with dark blue, IgG with light blue and IgA with red.

Mentions: Magnadottir [40] did a comparison of four different species, and found that serum IgM concentration in Atlantic salmon (~1 mg/mL) was significantly lower than in other species (Figure 3). This estimate is in agreement with measurements done in our laboratory [31].


Immunoglobulin isotypes in Atlantic salmon, Salmo salar.

Hordvik I - Biomolecules (2015)

Comparison of serum immunoglobulin (IgM) concentrations in different teleosts [40] compared to human (IgM + IgG + IgA). IgM is indicated with dark blue, IgG with light blue and IgA with red.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384117&req=5

biomolecules-05-00166-f003: Comparison of serum immunoglobulin (IgM) concentrations in different teleosts [40] compared to human (IgM + IgG + IgA). IgM is indicated with dark blue, IgG with light blue and IgA with red.
Mentions: Magnadottir [40] did a comparison of four different species, and found that serum IgM concentration in Atlantic salmon (~1 mg/mL) was significantly lower than in other species (Figure 3). This estimate is in agreement with measurements done in our laboratory [31].

Bottom Line: The IgM-B sub-variant has a characteristic extra cysteine near the C-terminal part of the heavy chain and exhibits a higher degree of polymer disulfide cross-linking compared to IgM-A.The concentration of IgT in serum is 100 to 1000 times lower than IgM.Secreted forms of IgD have been detected in rainbow trout, but not yet in Atlantic salmon.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology (BIO), High Technology Center, University of Bergen, Bergen N-5020, Norway. ivar.hordvik@bio.uib.no.

ABSTRACT
There are three major immunoglobulin (Ig) isotypes in salmonid fish: IgM, IgD and IgT, defined by the heavy chains μ, δ and τ, respectively. As a result of whole genome duplication in the ancestor of the salmonid fish family, Atlantic salmon (Salmo salar) possess two highly similar Ig heavy chain gene complexes (A and B), comprising two μ genes, two δ genes, three intact τ genes and five τ pseudogenes. The μA and μB genes correspond to two distinct sub-populations of serum IgM. The IgM-B sub-variant has a characteristic extra cysteine near the C-terminal part of the heavy chain and exhibits a higher degree of polymer disulfide cross-linking compared to IgM-A. The IgM-B:IgM-A ratio in serum is typically 60:40, but skewed ratios are also observed. The IgT isotype appears to be specialized to mucosal immune responses in salmonid fish. The concentration of IgT in serum is 100 to 1000 times lower than IgM. Secreted forms of IgD have been detected in rainbow trout, but not yet in Atlantic salmon.

Show MeSH
Related in: MedlinePlus