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Chitin, chitosan, and its derivatives for wound healing: old and new materials.

Azuma K, Izumi R, Osaki T, Ifuku S, Morimoto M, Saimoto H, Minami S, Okamoto Y - J Funct Biomater (2015)

Bottom Line: In this review, the studies on the wound-healing effects of chitin, chitosan, and its derivatives are summarized.Moreover, the development of adhesive-based chitin and chitosan are also described.Clinical applications of nano-based chitin and chitosan are also expected.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan. kazu-azuma@muses.tottori-u.ac.jp.

ABSTRACT
Chitin (β-(1-4)-poly-N-acetyl-D-glucosamine) is widely distributed in nature and is the second most abundant polysaccharide after cellulose. It is often converted to its more deacetylated derivative, chitosan. Previously, many reports have indicated the accelerating effects of chitin, chitosan, and its derivatives on wound healing. More recently, chemically modified or nano-fibrous chitin and chitosan have been developed, and their effects on wound healing have been evaluated. In this review, the studies on the wound-healing effects of chitin, chitosan, and its derivatives are summarized. Moreover, the development of adhesive-based chitin and chitosan are also described. The evidence indicates that chitin, chitosan, and its derivatives are beneficial for the wound healing process. More recently, it is also indicate that some nano-based materials from chitin and chitosan are beneficial than chitin and chitosan for wound healing. Clinical applications of nano-based chitin and chitosan are also expected.

No MeSH data available.


Related in: MedlinePlus

Histopathological changes. All images are from one of six rats in each group on day 14. The arrows indicate neutrophils. The arrowheads indicate fibroblasts. The asterisks indicate the adhesions. The clear arrows indicate multinucleated giant cells. Results on the low power fields (a,c,e,g,i) and high power fields (b,d,f,h,j) are shown. Scale bar: 200 mm (a,c,e,g,i) and 40 mm (b,d,f,h,j). Copyright 2015 Elsevier [177].
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jfb-06-00104-f010: Histopathological changes. All images are from one of six rats in each group on day 14. The arrows indicate neutrophils. The arrowheads indicate fibroblasts. The asterisks indicate the adhesions. The clear arrows indicate multinucleated giant cells. Results on the low power fields (a,c,e,g,i) and high power fields (b,d,f,h,j) are shown. Scale bar: 200 mm (a,c,e,g,i) and 40 mm (b,d,f,h,j). Copyright 2015 Elsevier [177].

Mentions: The adhesive strength of HMA-CM-chitin increased when it was blended with chitin nanofibers (CNFs) or surface-deacetylated chitin nanofibers (S-DACNFs). HMA-CM-chitin/CNFs or HMA-CM-chitin/S-DACNFs have almost equal adhesive strength compared to that of a commercial cyanoacrylate adhesive (Figure 9). Moreover, quick adhesion and induction of inflammatory cell migration were observed in HMA-CM-chitin/CNF and HMA-CM-chitin/S-DACNF. At 14 days after implantation, many multinucleated giant cells were observed in the cyanoacrylate group. On the other hand, less multinucleated giant cells were observed in the HMA-CM-chitin/CNF and HMA-CM-chitin/S-DACNF groups (Figure 10). These findings indicate that the composites prepared in this study are promising new biological adhesives.


Chitin, chitosan, and its derivatives for wound healing: old and new materials.

Azuma K, Izumi R, Osaki T, Ifuku S, Morimoto M, Saimoto H, Minami S, Okamoto Y - J Funct Biomater (2015)

Histopathological changes. All images are from one of six rats in each group on day 14. The arrows indicate neutrophils. The arrowheads indicate fibroblasts. The asterisks indicate the adhesions. The clear arrows indicate multinucleated giant cells. Results on the low power fields (a,c,e,g,i) and high power fields (b,d,f,h,j) are shown. Scale bar: 200 mm (a,c,e,g,i) and 40 mm (b,d,f,h,j). Copyright 2015 Elsevier [177].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384104&req=5

jfb-06-00104-f010: Histopathological changes. All images are from one of six rats in each group on day 14. The arrows indicate neutrophils. The arrowheads indicate fibroblasts. The asterisks indicate the adhesions. The clear arrows indicate multinucleated giant cells. Results on the low power fields (a,c,e,g,i) and high power fields (b,d,f,h,j) are shown. Scale bar: 200 mm (a,c,e,g,i) and 40 mm (b,d,f,h,j). Copyright 2015 Elsevier [177].
Mentions: The adhesive strength of HMA-CM-chitin increased when it was blended with chitin nanofibers (CNFs) or surface-deacetylated chitin nanofibers (S-DACNFs). HMA-CM-chitin/CNFs or HMA-CM-chitin/S-DACNFs have almost equal adhesive strength compared to that of a commercial cyanoacrylate adhesive (Figure 9). Moreover, quick adhesion and induction of inflammatory cell migration were observed in HMA-CM-chitin/CNF and HMA-CM-chitin/S-DACNF. At 14 days after implantation, many multinucleated giant cells were observed in the cyanoacrylate group. On the other hand, less multinucleated giant cells were observed in the HMA-CM-chitin/CNF and HMA-CM-chitin/S-DACNF groups (Figure 10). These findings indicate that the composites prepared in this study are promising new biological adhesives.

Bottom Line: In this review, the studies on the wound-healing effects of chitin, chitosan, and its derivatives are summarized.Moreover, the development of adhesive-based chitin and chitosan are also described.Clinical applications of nano-based chitin and chitosan are also expected.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan. kazu-azuma@muses.tottori-u.ac.jp.

ABSTRACT
Chitin (β-(1-4)-poly-N-acetyl-D-glucosamine) is widely distributed in nature and is the second most abundant polysaccharide after cellulose. It is often converted to its more deacetylated derivative, chitosan. Previously, many reports have indicated the accelerating effects of chitin, chitosan, and its derivatives on wound healing. More recently, chemically modified or nano-fibrous chitin and chitosan have been developed, and their effects on wound healing have been evaluated. In this review, the studies on the wound-healing effects of chitin, chitosan, and its derivatives are summarized. Moreover, the development of adhesive-based chitin and chitosan are also described. The evidence indicates that chitin, chitosan, and its derivatives are beneficial for the wound healing process. More recently, it is also indicate that some nano-based materials from chitin and chitosan are beneficial than chitin and chitosan for wound healing. Clinical applications of nano-based chitin and chitosan are also expected.

No MeSH data available.


Related in: MedlinePlus