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Chitin, chitosan, and its derivatives for wound healing: old and new materials.

Azuma K, Izumi R, Osaki T, Ifuku S, Morimoto M, Saimoto H, Minami S, Okamoto Y - J Funct Biomater (2015)

Bottom Line: In this review, the studies on the wound-healing effects of chitin, chitosan, and its derivatives are summarized.Moreover, the development of adhesive-based chitin and chitosan are also described.Clinical applications of nano-based chitin and chitosan are also expected.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan. kazu-azuma@muses.tottori-u.ac.jp.

ABSTRACT
Chitin (β-(1-4)-poly-N-acetyl-D-glucosamine) is widely distributed in nature and is the second most abundant polysaccharide after cellulose. It is often converted to its more deacetylated derivative, chitosan. Previously, many reports have indicated the accelerating effects of chitin, chitosan, and its derivatives on wound healing. More recently, chemically modified or nano-fibrous chitin and chitosan have been developed, and their effects on wound healing have been evaluated. In this review, the studies on the wound-healing effects of chitin, chitosan, and its derivatives are summarized. Moreover, the development of adhesive-based chitin and chitosan are also described. The evidence indicates that chitin, chitosan, and its derivatives are beneficial for the wound healing process. More recently, it is also indicate that some nano-based materials from chitin and chitosan are beneficial than chitin and chitosan for wound healing. Clinical applications of nano-based chitin and chitosan are also expected.

No MeSH data available.


Related in: MedlinePlus

Chemical structure of 2-hydroxy-3-methacryloyloxypropylated carboxymethyl chitin (HMA-CM-chitin). Copyright 2015 Elsevier [177].
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jfb-06-00104-f008: Chemical structure of 2-hydroxy-3-methacryloyloxypropylated carboxymethyl chitin (HMA-CM-chitin). Copyright 2015 Elsevier [177].

Mentions: More recently, we reported that novel biological adhesives made from chitin derivatives were prepared and evaluated for their adhesive properties and biocompatibility [177]. Chitin derivatives with acrylic groups, such as 2-hydroxy-3-methacryloyloxypropylated carboxymethyl chitin (HMA-CM-chitin; Figure 8), were synthesized and cured by the addition of an aqueous hydrogen peroxide solution as a radical initiator.


Chitin, chitosan, and its derivatives for wound healing: old and new materials.

Azuma K, Izumi R, Osaki T, Ifuku S, Morimoto M, Saimoto H, Minami S, Okamoto Y - J Funct Biomater (2015)

Chemical structure of 2-hydroxy-3-methacryloyloxypropylated carboxymethyl chitin (HMA-CM-chitin). Copyright 2015 Elsevier [177].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384104&req=5

jfb-06-00104-f008: Chemical structure of 2-hydroxy-3-methacryloyloxypropylated carboxymethyl chitin (HMA-CM-chitin). Copyright 2015 Elsevier [177].
Mentions: More recently, we reported that novel biological adhesives made from chitin derivatives were prepared and evaluated for their adhesive properties and biocompatibility [177]. Chitin derivatives with acrylic groups, such as 2-hydroxy-3-methacryloyloxypropylated carboxymethyl chitin (HMA-CM-chitin; Figure 8), were synthesized and cured by the addition of an aqueous hydrogen peroxide solution as a radical initiator.

Bottom Line: In this review, the studies on the wound-healing effects of chitin, chitosan, and its derivatives are summarized.Moreover, the development of adhesive-based chitin and chitosan are also described.Clinical applications of nano-based chitin and chitosan are also expected.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan. kazu-azuma@muses.tottori-u.ac.jp.

ABSTRACT
Chitin (β-(1-4)-poly-N-acetyl-D-glucosamine) is widely distributed in nature and is the second most abundant polysaccharide after cellulose. It is often converted to its more deacetylated derivative, chitosan. Previously, many reports have indicated the accelerating effects of chitin, chitosan, and its derivatives on wound healing. More recently, chemically modified or nano-fibrous chitin and chitosan have been developed, and their effects on wound healing have been evaluated. In this review, the studies on the wound-healing effects of chitin, chitosan, and its derivatives are summarized. Moreover, the development of adhesive-based chitin and chitosan are also described. The evidence indicates that chitin, chitosan, and its derivatives are beneficial for the wound healing process. More recently, it is also indicate that some nano-based materials from chitin and chitosan are beneficial than chitin and chitosan for wound healing. Clinical applications of nano-based chitin and chitosan are also expected.

No MeSH data available.


Related in: MedlinePlus