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Preparation and preliminary dialysis performance research of polyvinylidene fluoride hollow fiber membranes.

Zhang Q, Lu X, Liu J, Zhao L - Membranes (Basel) (2015)

Bottom Line: The results showed that the clearance rate of urea and Lysozyme (LZM) were improved with increasing membrane area and fluid flow rate while the rejection of albumin from bovine serum (BSA) had little influence.The PVDF dialyzer with membrane area 0.69 m2 has the highest clearance rate to LZM and urea.The clearance rate of LZM was 66.8% and urea was 87.7%.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biological and Chemical Engineering, Tianjin Polytechnic University, Tianjin 300387, China. haiyang19802005@163.com.

ABSTRACT
In this study, the separation properties of Polyvinylidene fluoride (PVDF) hollow fiber hemodialysis membranes were improved by optimizing membrane morphology and structure. The results showed that the PVDF membrane had better mechanical and separation properties than Fresenius Polysulfone High-Flux (F60S) membrane. The PVDF membrane tensile stress at break, tensile elongation and bursting pressure were 11.3 MPa, 395% and 0.625 MPa, respectively. Ultrafiltration (UF) flux of pure water reached 108.2 L∙h-1∙m-2 and rejection of Albumin from bovine serum was 82.3%. The PVDF dialyzers were prepared by centrifugal casting. The influences of membrane area and simulate fluid flow rate on dialysis performance were investigated. The results showed that the clearance rate of urea and Lysozyme (LZM) were improved with increasing membrane area and fluid flow rate while the rejection of albumin from bovine serum (BSA) had little influence. The high-flux PVDF dialyzer UF coefficient reached 62.6 mL/h/mmHg. The PVDF dialyzer with membrane area 0.69 m2 has the highest clearance rate to LZM and urea. The clearance rate of LZM was 66.8% and urea was 87.7%.

No MeSH data available.


Related in: MedlinePlus

The stress-strain curves of different PVDF membranes, the labels M-1, M-2, M-3 and M-4 are membranes with PEG molecular weights 2, 4, 6 and 10 kDa, respectively.
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membranes-05-00120-f006: The stress-strain curves of different PVDF membranes, the labels M-1, M-2, M-3 and M-4 are membranes with PEG molecular weights 2, 4, 6 and 10 kDa, respectively.

Mentions: The tensile stress and bursting pressure at break increases with increasing PEG molecular weight at first, and then decreases, as shown in Table 1 and Figure 6. M-3 membrane has the best mechanical properties. The membrane tensile stress at break is 11.3 MPa and bursting pressure at break is 0.625 MPa. This can be explained by two reasons: (1) the cross-sectional structure can affect the membrane mechanical performance. From morphologies (Figure 2), it can be seen that the finger-like structure becomes less and less with increasing PEG molecular weigh, which can increase the tensile stress. With PEG molecular weight continuing to increase, the casting solution stability is deteriorated and the membrane mechanical performance begins to decrease; (2) the porosity can also affect the mechanical performance. From Table 1, the porosity decreases from 88.9% to 85.1%, and then increases to 87.8%. The higher porosity membrane has lower mechanical performance.


Preparation and preliminary dialysis performance research of polyvinylidene fluoride hollow fiber membranes.

Zhang Q, Lu X, Liu J, Zhao L - Membranes (Basel) (2015)

The stress-strain curves of different PVDF membranes, the labels M-1, M-2, M-3 and M-4 are membranes with PEG molecular weights 2, 4, 6 and 10 kDa, respectively.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384094&req=5

membranes-05-00120-f006: The stress-strain curves of different PVDF membranes, the labels M-1, M-2, M-3 and M-4 are membranes with PEG molecular weights 2, 4, 6 and 10 kDa, respectively.
Mentions: The tensile stress and bursting pressure at break increases with increasing PEG molecular weight at first, and then decreases, as shown in Table 1 and Figure 6. M-3 membrane has the best mechanical properties. The membrane tensile stress at break is 11.3 MPa and bursting pressure at break is 0.625 MPa. This can be explained by two reasons: (1) the cross-sectional structure can affect the membrane mechanical performance. From morphologies (Figure 2), it can be seen that the finger-like structure becomes less and less with increasing PEG molecular weigh, which can increase the tensile stress. With PEG molecular weight continuing to increase, the casting solution stability is deteriorated and the membrane mechanical performance begins to decrease; (2) the porosity can also affect the mechanical performance. From Table 1, the porosity decreases from 88.9% to 85.1%, and then increases to 87.8%. The higher porosity membrane has lower mechanical performance.

Bottom Line: The results showed that the clearance rate of urea and Lysozyme (LZM) were improved with increasing membrane area and fluid flow rate while the rejection of albumin from bovine serum (BSA) had little influence.The PVDF dialyzer with membrane area 0.69 m2 has the highest clearance rate to LZM and urea.The clearance rate of LZM was 66.8% and urea was 87.7%.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biological and Chemical Engineering, Tianjin Polytechnic University, Tianjin 300387, China. haiyang19802005@163.com.

ABSTRACT
In this study, the separation properties of Polyvinylidene fluoride (PVDF) hollow fiber hemodialysis membranes were improved by optimizing membrane morphology and structure. The results showed that the PVDF membrane had better mechanical and separation properties than Fresenius Polysulfone High-Flux (F60S) membrane. The PVDF membrane tensile stress at break, tensile elongation and bursting pressure were 11.3 MPa, 395% and 0.625 MPa, respectively. Ultrafiltration (UF) flux of pure water reached 108.2 L∙h-1∙m-2 and rejection of Albumin from bovine serum was 82.3%. The PVDF dialyzers were prepared by centrifugal casting. The influences of membrane area and simulate fluid flow rate on dialysis performance were investigated. The results showed that the clearance rate of urea and Lysozyme (LZM) were improved with increasing membrane area and fluid flow rate while the rejection of albumin from bovine serum (BSA) had little influence. The high-flux PVDF dialyzer UF coefficient reached 62.6 mL/h/mmHg. The PVDF dialyzer with membrane area 0.69 m2 has the highest clearance rate to LZM and urea. The clearance rate of LZM was 66.8% and urea was 87.7%.

No MeSH data available.


Related in: MedlinePlus