UniProt: a hub for protein information.
Bottom Line: We present a new website that has been designed using a user-experience design process.We have introduced an annotation score for all entries in UniProt to represent the relative amount of knowledge known about each protein.These scores will be helpful in identifying which proteins are the best characterized and most informative for comparative analysis.
Related in: MedlinePlus
Mentions: The coverage of UniProtKB/TrEMBL has grown from 28% to 35% over the last 4 years despite the exponential increase in the size of the database, see Figure 5. This is due in part to a large amount of the increase being the result of the integration of redundant complete bacterial proteomes, which have been annotated by our existing UniRules for bacteria. Our strategy for addressing this redundancy will be discussed in the proteome section in this paper. Our automatic annotation priorities for UniRule generation are (i) to focus on using and annotating new functional data of interest for proteomes, such as enzymes and pathways and (ii) to expand our coverage into new taxonomic and protein families and (iii) to expand the scope of annotations by leveraging curated data via collaboration with external groups, as is the case with post-translational modification (PTM) data in RESID database (as an example see UniRule annotation of (UniProt F2I0T3) in the PTM/Processing section, with rule information based on RESID:AA0120).