UniProt: a hub for protein information.
Bottom Line: We present a new website that has been designed using a user-experience design process.We have introduced an annotation score for all entries in UniProt to represent the relative amount of knowledge known about each protein.These scores will be helpful in identifying which proteins are the best characterized and most informative for comparative analysis.
Related in: MedlinePlus
Mentions: To gauge UniProt's impact on the research community we analysed the scientific literature citing UniProt Consortium publications (a set of 38 publications) in the time period 2002–14 with the aid of Thompson Reuters Web of Science tools. Overall UniProt publications were cited 3576 times in 898 unique journal titles. The distribution of citations per year is shown in Figure 9. The main research areas that these publications covered based on the indexing categories provided by Web of Science included Biochemistry and Molecular biology (over 50%), Biotechnology, Computational biology, Computer Science and Genetics, among others (see Figure 10). We also looked at the ISI 5 year Journal impact factor for this set of articles citing UniProt. The median score for the journals with 10 or more publications citing UniProt is 4.3. Note that there were 48 publications with impact factor over 20. These results illustrate that UniProt is widely used in broad areas of biomedical research, from algorithm development (using UniProt annotations as data sets, or the sequences), to resource building (integrating data from UniProt or providing links to UniProt data) and to protein identification, functional annotation and comparative studies. The citation numbers are an undercount as we have noted many examples where UniProt or other widely known resources are either not cited or cited in a way that was not recorded in the citation database. For example, a recent publication in the journal Cell made extensive use of UniProt annotation in defining a nuclear import pathway for ankyrin repeat containing proteins (18). Although UniProt was clearly mentioned throughout in the article text it was only cited in supplemental material, which is not included in many citation-tracking services.