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Mouse Tumor Biology (MTB): a database of mouse models for human cancer.

Bult CJ, Krupke DM, Begley DA, Richardson JE, Neuhauser SB, Sundberg JP, Eppig JT - Nucleic Acids Res. (2014)

Bottom Line: The information in MTB is designed to facilitate the selection of strains for cancer research and is a platform for mining data on tumor development and patterns of metastases.MTB curators acquire data through manual curation of peer-reviewed scientific literature and from direct submissions by researchers.Data in MTB are also obtained from other bioinformatics resources including PathBase, the Gene Expression Omnibus and ArrayExpress.

View Article: PubMed Central - PubMed

Affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA carol.bult@jax.org.

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Related in: MedlinePlus

Examples of PDX characterization data accessed from MTB's PDX model web portal. (A) Description of the concordance of morphological features of primary patient tumor and engrafted tumors. (B) Circos plot showing integration of genomic data from PDX tumor. (C) Tumor growth characteristics of similar tumors in different PDX models. (D) Tumor growth curves from a drug response study comparing four different treatments in tumor-bearing mice.
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Figure 3: Examples of PDX characterization data accessed from MTB's PDX model web portal. (A) Description of the concordance of morphological features of primary patient tumor and engrafted tumors. (B) Circos plot showing integration of genomic data from PDX tumor. (C) Tumor growth characteristics of similar tumors in different PDX models. (D) Tumor growth curves from a drug response study comparing four different treatments in tumor-bearing mice.

Mentions: MTB supports online access to all of the available PDX models from The Jackson Laboratory's PDX Resource. The models in this resource have been comprehensively annotated for clinical information (de-identified) about the patients from whom the primary tumor material was obtained, histopathology and diagnostic marker labeling, whole genome copy number variation (CNV), genome-wide transcriptional profiling and targeted exome sequencing. Subsets of the models have tumor growth data and standard of care drug response data from dosing studies in tumor-bearing mice. When histopathology images of both the primary patient tumor and the engrafted tumors are available, a board certified pathologist reviews the images and provides a summary of the degree to which there is concordance of the morphological features between the primary and engrafted tumors. The user interfaces to the PDX associated data support searches for models by cancer type, patient diagnosis and genomic properties of the engrafted tumor (expression, CNV and/or mutation) (Figure 3). Tabular summaries of variants identified in the engrafted tumors and graphical summaries of gene expression, amplifications and deletions are also provided for each model. Users can request information on the availability of tumor fragments and tumor-bearing mice using a web-based form that is forwarded to the customer services group at The Jackson Laboratory.


Mouse Tumor Biology (MTB): a database of mouse models for human cancer.

Bult CJ, Krupke DM, Begley DA, Richardson JE, Neuhauser SB, Sundberg JP, Eppig JT - Nucleic Acids Res. (2014)

Examples of PDX characterization data accessed from MTB's PDX model web portal. (A) Description of the concordance of morphological features of primary patient tumor and engrafted tumors. (B) Circos plot showing integration of genomic data from PDX tumor. (C) Tumor growth characteristics of similar tumors in different PDX models. (D) Tumor growth curves from a drug response study comparing four different treatments in tumor-bearing mice.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384039&req=5

Figure 3: Examples of PDX characterization data accessed from MTB's PDX model web portal. (A) Description of the concordance of morphological features of primary patient tumor and engrafted tumors. (B) Circos plot showing integration of genomic data from PDX tumor. (C) Tumor growth characteristics of similar tumors in different PDX models. (D) Tumor growth curves from a drug response study comparing four different treatments in tumor-bearing mice.
Mentions: MTB supports online access to all of the available PDX models from The Jackson Laboratory's PDX Resource. The models in this resource have been comprehensively annotated for clinical information (de-identified) about the patients from whom the primary tumor material was obtained, histopathology and diagnostic marker labeling, whole genome copy number variation (CNV), genome-wide transcriptional profiling and targeted exome sequencing. Subsets of the models have tumor growth data and standard of care drug response data from dosing studies in tumor-bearing mice. When histopathology images of both the primary patient tumor and the engrafted tumors are available, a board certified pathologist reviews the images and provides a summary of the degree to which there is concordance of the morphological features between the primary and engrafted tumors. The user interfaces to the PDX associated data support searches for models by cancer type, patient diagnosis and genomic properties of the engrafted tumor (expression, CNV and/or mutation) (Figure 3). Tabular summaries of variants identified in the engrafted tumors and graphical summaries of gene expression, amplifications and deletions are also provided for each model. Users can request information on the availability of tumor fragments and tumor-bearing mice using a web-based form that is forwarded to the customer services group at The Jackson Laboratory.

Bottom Line: The information in MTB is designed to facilitate the selection of strains for cancer research and is a platform for mining data on tumor development and patterns of metastases.MTB curators acquire data through manual curation of peer-reviewed scientific literature and from direct submissions by researchers.Data in MTB are also obtained from other bioinformatics resources including PathBase, the Gene Expression Omnibus and ArrayExpress.

View Article: PubMed Central - PubMed

Affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA carol.bult@jax.org.

Show MeSH
Related in: MedlinePlus