The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease.
Bottom Line: MGD maintains a unified catalog of genes and genome features, including functional RNAs, QTL and phenotypic loci.MGD has also updated search paradigms for phenotypic allele attributes, incorporated incidental mutation data, added a module for display and exploration of genes and microRNA interactions and adopted the JBrowse genome browser.MGD resources are freely available to the scientific community.
Affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA firstname.lastname@example.org.Show MeSH
Mentions: The MGD schema and web pages reflecting data on allele categories, attributes and project collections have been re-implemented and expanded. Formerly allele categories included multiple concepts within a single term. For example, the categorical term targeted (knock-out) referred to mutant alleles that were generated by gene targeting techniques and were functionally . This term now is represented as a Generation Method of targeted and an Allele Attribute of /knockout. The change separates the generation method and attributes concepts and allows users to consider multiple attributes simultaneously (Figure 6), for example reporter and /knockout—if the targeted mutation includes a LacZ reporter, as well as ablating gene function. The additional category of project collections is an enhancement to assist in accessing all mutant alleles from a large-scale project in a single search, for example all of the mutant alleles created by the Pleiades Promoter Project (22) or by the B2B/CvDC (Bench-to-Bassinet/Cardiovascular Development Consortium) Project (21) (Figure 7).
Affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA email@example.com.