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CATH: comprehensive structural and functional annotations for genome sequences.

Sillitoe I, Lewis TE, Cuff A, Das S, Ashford P, Dawson NL, Furnham N, Laskowski RA, Lee D, Lees JG, Lehtinen S, Studer RA, Thornton J, Orengo CA - Nucleic Acids Res. (2014)

Bottom Line: The latest version of the CATH-Gene3D protein structure classification database (4.0, http://www.cathdb.info) provides annotations for over 235,000 protein domain structures and includes 25 million domain predictions.This article provides an update on the major developments in the 2 years since the last publication in this journal including: significant improvements to the predictive power of our functional families (FunFams); the release of our 'current' putative domain assignments (CATH-B); a new, strictly non-redundant data set of CATH domains suitable for homology benchmarking experiments (CATH-40) and a number of improvements to the web pages.

View Article: PubMed Central - PubMed

Affiliation: Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK i.sillitoe@ucl.ac.uk.

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Superposition of 15 representative domains from the Homing endonucleases superfamily (CATH: 3.10.28.10).
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Figure 3: Superposition of 15 representative domains from the Homing endonucleases superfamily (CATH: 3.10.28.10).

Mentions: Since the previous paper, we have added superfamily superpositions to the CATH superfamily web pages. These are superpositions of all representative domains within a superfamily (selected from sequence clusters at 35% sequence identity over 80% overlap). Figure 3 shows a superposition of the 15 representative domains in the Homing endonucleases superfamily in CATH v4.0 (3.10.28.10) coloured by secondary structure and by rainbow.


CATH: comprehensive structural and functional annotations for genome sequences.

Sillitoe I, Lewis TE, Cuff A, Das S, Ashford P, Dawson NL, Furnham N, Laskowski RA, Lee D, Lees JG, Lehtinen S, Studer RA, Thornton J, Orengo CA - Nucleic Acids Res. (2014)

Superposition of 15 representative domains from the Homing endonucleases superfamily (CATH: 3.10.28.10).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4384018&req=5

Figure 3: Superposition of 15 representative domains from the Homing endonucleases superfamily (CATH: 3.10.28.10).
Mentions: Since the previous paper, we have added superfamily superpositions to the CATH superfamily web pages. These are superpositions of all representative domains within a superfamily (selected from sequence clusters at 35% sequence identity over 80% overlap). Figure 3 shows a superposition of the 15 representative domains in the Homing endonucleases superfamily in CATH v4.0 (3.10.28.10) coloured by secondary structure and by rainbow.

Bottom Line: The latest version of the CATH-Gene3D protein structure classification database (4.0, http://www.cathdb.info) provides annotations for over 235,000 protein domain structures and includes 25 million domain predictions.This article provides an update on the major developments in the 2 years since the last publication in this journal including: significant improvements to the predictive power of our functional families (FunFams); the release of our 'current' putative domain assignments (CATH-B); a new, strictly non-redundant data set of CATH domains suitable for homology benchmarking experiments (CATH-40) and a number of improvements to the web pages.

View Article: PubMed Central - PubMed

Affiliation: Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK i.sillitoe@ucl.ac.uk.

Show MeSH