TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.
Bottom Line: The metabolic network of a cell represents the catabolic and anabolic reactions that interconvert small molecules (metabolites) through the activity of enzymes, transporters and non-catalyzed chemical reactions.Our understanding of individual metabolic networks is increasing as we learn more about the enzymes that are active in particular cells under particular conditions and as technologies advance to allow detailed measurements of the cellular metabolome.Metabolic network databases are of increasing importance in allowing us to contextualise data sets emerging from transcriptomic, proteomic and metabolomic experiments.
Affiliation: Institut National de la Recherche Agronomique (INRA), UMR1331, TOXALIM (Research Centre in Food Toxicology), Université de Toulouse, Toulouse, France.Show MeSH
Related in: MedlinePlus
Mentions: As a Pathway Tools-based website, TrypanoCyc provides a dedicated web page for each metabolic network entity (pathways, reactions, metabolites, enzymes, proteins and genes). The reaction page architecture was, however, modified in order to allow additional annotation information. These include the annotation confidence score (Figure 1d), stage specificity and compartmentation with links to key literature (Figure 1e). A comment box is also included, containing detailed free-text information on the reaction. Figure 1 shows the webpage for the pentose phosphate pathway enzyme, 6-phosphogluconate dehydrogenase (EC. 188.8.131.52).
Affiliation: Institut National de la Recherche Agronomique (INRA), UMR1331, TOXALIM (Research Centre in Food Toxicology), Université de Toulouse, Toulouse, France.