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DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions.

Vlachos IS, Paraskevopoulou MD, Karagkouni D, Georgakilas G, Vergoulis T, Kanellos I, Anastasopoulos IL, Maniou S, Karathanou K, Kalfakakou D, Fevgas A, Dalamagas T, Hatzigeorgiou AG - Nucleic Acids Res. (2014)

Bottom Line: The new interface provides also advanced information ranging from the binding site location, as identified experimentally as well as in silico, to the primer sequences used for cloning experiments.More than half a million miRNA:gene interactions have been curated from published experiments on 356 different cell types from 24 species, corresponding to 9- to 250-fold more entries than any other relevant database.DIANA-TarBase v7.0 is freely available.

View Article: PubMed Central - PubMed

Affiliation: DIANA-Lab, Department of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece Laboratory for Experimental Surgery and Surgical Research 'N.S. Christeas', Medical School of Athens, University of Athens, 11527 Athens, Greece arhatzig@uth.gr dalamag@imis.athena-innovation.gr ivlachos@lessr.eu.

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Related in: MedlinePlus

Screen-shot depicting the DIANA-TarBase v7.0 interface. Users can enter the query terms in the simple search box (1). Interaction information is presented below (2), while further details are accessible by expanding the result panel or by selecting the information links (4). All results are color-coded, with green and red showing positive and negative experimental outcomes, respectively (5). Mixed results are presented using both colors. Users can filter the query results using any combination of the filtering options (3).
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Figure 2: Screen-shot depicting the DIANA-TarBase v7.0 interface. Users can enter the query terms in the simple search box (1). Interaction information is presented below (2), while further details are accessible by expanding the result panel or by selecting the information links (4). All results are color-coded, with green and red showing positive and negative experimental outcomes, respectively (5). Mixed results are presented using both colors. Users can filter the query results using any combination of the filtering options (3).

Mentions: The interface (Figure 2) is designed around the new database schema, in order to cater to users extended meta-data regarding each interaction. Users can easily identify positive or negative experimental results, the utilized experimental methodology, experimental conditions including cell/tissue type and treatment. The new interface provides also advanced information ranging from the binding site location, as identified experimentally as well as in silico, to the primer sequences used for cloning experiments.


DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions.

Vlachos IS, Paraskevopoulou MD, Karagkouni D, Georgakilas G, Vergoulis T, Kanellos I, Anastasopoulos IL, Maniou S, Karathanou K, Kalfakakou D, Fevgas A, Dalamagas T, Hatzigeorgiou AG - Nucleic Acids Res. (2014)

Screen-shot depicting the DIANA-TarBase v7.0 interface. Users can enter the query terms in the simple search box (1). Interaction information is presented below (2), while further details are accessible by expanding the result panel or by selecting the information links (4). All results are color-coded, with green and red showing positive and negative experimental outcomes, respectively (5). Mixed results are presented using both colors. Users can filter the query results using any combination of the filtering options (3).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383989&req=5

Figure 2: Screen-shot depicting the DIANA-TarBase v7.0 interface. Users can enter the query terms in the simple search box (1). Interaction information is presented below (2), while further details are accessible by expanding the result panel or by selecting the information links (4). All results are color-coded, with green and red showing positive and negative experimental outcomes, respectively (5). Mixed results are presented using both colors. Users can filter the query results using any combination of the filtering options (3).
Mentions: The interface (Figure 2) is designed around the new database schema, in order to cater to users extended meta-data regarding each interaction. Users can easily identify positive or negative experimental results, the utilized experimental methodology, experimental conditions including cell/tissue type and treatment. The new interface provides also advanced information ranging from the binding site location, as identified experimentally as well as in silico, to the primer sequences used for cloning experiments.

Bottom Line: The new interface provides also advanced information ranging from the binding site location, as identified experimentally as well as in silico, to the primer sequences used for cloning experiments.More than half a million miRNA:gene interactions have been curated from published experiments on 356 different cell types from 24 species, corresponding to 9- to 250-fold more entries than any other relevant database.DIANA-TarBase v7.0 is freely available.

View Article: PubMed Central - PubMed

Affiliation: DIANA-Lab, Department of Electrical & Computer Engineering, University of Thessaly, 382 21 Volos, Greece Laboratory for Experimental Surgery and Surgical Research 'N.S. Christeas', Medical School of Athens, University of Athens, 11527 Athens, Greece arhatzig@uth.gr dalamag@imis.athena-innovation.gr ivlachos@lessr.eu.

Show MeSH
Related in: MedlinePlus