The neXtProt knowledgebase on human proteins: current status.
Bottom Line: Focused solely on human proteins, neXtProt aims to provide a state of the art resource for the representation of human biology by capturing a wide range of data, precise annotations, fully traceable data provenance and a web interface which enables researchers to find and view information in a comprehensive manner.Since the introductory neXtProt publication, significant advances have been made on three main aspects: the representation of proteomics data, an extended representation of human variants and the development of an advanced search capability built around semantic technologies.These changes are presented in the current neXtProt update.
Affiliation: CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211 Department of Human Protein Sciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland, 1211 firstname.lastname@example.org.Show MeSH
Mentions: A major advance in the neXtProt functionality is the availability of a new advanced search system, designed to support the retrieval of proteins based on highly precise criteria taking into account the richness of the annotations and evidences. To implement this new functionality, we have converted the relational database into a graph representation using a subject-predicate-object model, RDF-based (Resource Description Framework). The graph representation is extremely powerful to navigate through the richness of the neXtProt data and to search it using the SPARQL query language. The advanced search is accessible at http://search.nextprot.org. An example query is shown in Figure 4.
Affiliation: CALIPHO group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland, 1211 Department of Human Protein Sciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland, 1211 email@example.com.