LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression.
Bottom Line: Long non-coding RNAs (lncRNAs) have emerged as critical regulators of genes at epigenetic, transcriptional and post-transcriptional levels, yet what genes are regulated by a specific lncRNA remains to be characterized.To assess the effects of the lncRNA on gene expression, an increasing number of researchers profiled the genome-wide or individual gene expression level change after knocking down or overexpressing the lncRNA.Both search types are performed either by browsing a provided catalog of lncRNA names or by inserting lncRNA/target gene IDs/names in a search box.
Affiliation: School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.Show MeSH
Mentions: Data in LncRNA2Target database can be browsed by lncRNA symbol. To browse the data, users first go into the ‘Browse’ page, and then select a species and a lncRNA they are interested in. For example, if the user wants to get target genes of the human lncRNA ‘INRIL’, you can click ‘+Human’ first and then select ‘INRIL’. The corresponding entries will be shown on the right panel. In this panel, basic lncRNA information are shown, such as lncRNA symbol used in the original paper, official lncRNA symbol, its entrez or Ensembl gene ID, genomic location, strand, etc. In addition, the target genes of the lncRNA, cell line in which the lncRNA knockdown/overexpression experiments was performed, disease state and reference information are also shown in this panel. When users click the target symbol, a new window will be popped up, where the experimental evidence for supporting the lncRNA-target association is shown. An example on how to get the target genes of lncRNA ‘INRIL’ is shown in the Figure 1.
Affiliation: School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.