YM500v2: a small RNA sequencing (smRNA-seq) database for human cancer miRNome research.
Bottom Line: We previously presented YM500, which is an integrated database for miRNA quantification, isomiR identification, arm switching discovery and novel miRNA prediction from 468 human smRNA-seq datasets.A new function 'Meta-analysis' is additionally provided for allowing users to identify real-time differentially expressed miRNAs and arm-switching events according to customer-defined sample groups and dozens of clinical criteria tidying up by proficient clinicians.Cancer miRNAs identified hold the potential for both basic research and biotech applications.
Affiliation: Research Center for Tumor Medical Science, China Medical University, Taichung 40402, Taiwan.Show MeSH
Related in: MedlinePlus
Mentions: Two statistical charts are added to the ‘IsomiR’ section to help researchers realize the expression profile of an isomiR across distinct tissues. miR-21-5p+CA, an isomiR of miR-21-5p adenylated by PAPD5 reported to lead the degradation of miR-21-5p (24), is used as an example (Figure 3). Figure 3A shows the percentage of samples that expressed this isomiR in various tissues, and Figure 3B indicates the mean expression of a specific isomiR.
Affiliation: Research Center for Tumor Medical Science, China Medical University, Taichung 40402, Taiwan.