Cancer3D: understanding cancer mutations through protein structures.
Bottom Line: This approach allows users to find novel candidate driver regions or drug biomarkers that cannot be found when similar analyses are done on the whole-gene level.In addition, it displays mutations from over 14,700 proteins mapped to more than 24,300 structures from PDB.This helps users visualize the distribution of mutations and identify novel three-dimensional patterns in their distribution.
Affiliation: Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.Show MeSH
Related in: MedlinePlus
Mentions: After the initial selections, the user is forwarded to the main page (Figure 2). The main page can essentially have two views: (i) the e-Driver or (ii) the e-Drug view. Switching between these views is possible by selecting a region or region–drug combination in the respective menus. The ‘Mutation Frequency’ or ‘Drug’ buttons in the menu bar allow the user to immediately switch between the e-Driver and e-Drug views for the currently selected region. The user can access view-specific help texts for the current view state by clicking on one of the question-mark symbols.
Affiliation: Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.