VirHostNet 2.0: surfing on the web of virus/host molecular interactions data.
Bottom Line: This resource is shared publicly, in PSI-MI TAB 2.5 format, using a PSICQUIC web service.The new interface of VirHostNet 2.0 is based on Cytoscape web library and provides a user-friendly access to the most complete and accurate resource of virus-virus and virus-host protein-protein interactions as well as their projection onto their corresponding host cell protein interaction networks.This resource will also continue to help worldwide scientists to improve our knowledge on molecular mechanisms involved in the antiviral response mediated by the cell and in the viral strategies selected by viruses to hijack the host immune system.
Affiliation: PRABI, Rhône Alpes Bioinformatics Center, UCBL, Lyon1, Université de Lyon, Lyon, France.Show MeSH
Related in: MedlinePlus
Mentions: Our new round of biocuration results in a 5-fold enrichment according to the previous release 1.0 of VirHostNet. Over 30 000 ppi are now annotated, with a total of 16 000 VH, 2 500 VV and 12 000 host/host (HH) ppi (Figure 1a, Supplementary Table S1). A comparison to the data stored in known available databases reveals that more than 80% of annotated interactions are unique to the VirHostNet 2.0 resource, confirming the relatively high sensitivity of our fast annotation approach. It is interesting to note that 50 and 42% of VH ppi data were obtained by TAP and Y2H experiment, respectively (Figure 1b). Moreover, more than 33% of the VirHostNet 2.0 ppi are supported by at least two independent experiments, suggesting the high quality of those interactions (Figure 1c).
Affiliation: PRABI, Rhône Alpes Bioinformatics Center, UCBL, Lyon1, Université de Lyon, Lyon, France.