The GOA database: gene Ontology annotation updates for 2015.
Bottom Line: The resource now provides annotations to five times the number of proteins it did 4 years ago.As a member of the GO Consortium, we adhere to the most up-to-date Consortium-agreed annotation guidelines via the use of quality control checks that ensures that the GOA resource supplies high-quality functional information to proteins from a wide range of species.Annotations from GOA are freely available and are accessible through a powerful web browser as well as a variety of annotation file formats.
Affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK email@example.com.Show MeSH
Mentions: The introduction of subsets of GO terms that are deemed not suitable for direct annotation meant that it was necessary to report the annotations that use these terms in order for them to be corrected and to prevent curators from making new annotations to these terms. For example, the prohibition of cell cycle phase-type terms (e.g. ‘metaphase’ (GO:0051323)) in primary GO annotations led to a restriction being added to Protein2GO, which prevents curators from annotating directly to these GO terms, but curators are still able to use them in the annotation extension field. Any existing annotations using these terms had to be reviewed and either updated to a more appropriate term or deleted. Additionally, when importing data from other curation groups, these types of annotation are excluded from our database. When these GO terms are viewed in QuickGO, there is an alert informing that the term is not to be used for direct annotation (Figure 3).
Affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK firstname.lastname@example.org.